Erbin Erbb2 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erbinprovided by MGI
Official Full Name: Erbb2 interacting proteinprovided by MGI
Primary source: MGI:MGI:1890169
See related: Ensembl:ENSMUSG00000021709 AllianceGenome:MGI:1890169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erbb2ip; mKIAA1225; 1700028E05Rik
Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of monocyte chemotactic protein-1 production; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within protein targeting. Located in basolateral plasma membrane and glutamatergic synapse. Is active in postsynapse. Is expressed in cerebral cortex and retina nuclear layer. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 12.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.16 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (103955294..104057094, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (103818786..103920586, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries.
Title: Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries.
Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury.
Title: Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury.
Tumor organoids derived from Erbin/Apc double knockout mice displayed increased tumor initiation potential and activation of Wnt signaling
Title: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased.
Title: FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy.
By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence
Title: Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor
Title: Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR.
Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway
Title: Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.
Erbin is an inhibitor of pathological cardiac hypertrophy.
Title: Erbin is a negative modulator of cardiac hypertrophy.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin positive interneurons
Title: Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons.
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 and NRG1 levels, identifying a novel player in regulating remyelination.
Title: Erbin is required for myelination in regenerated axons after injury.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G07329 (e-PCR)
- UniSTS:42247

NoName (e-PCR)
- UniSTS:237100

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: erbin

Names: densin-180-like protein; erbb2-interacting protein; protein LAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005868.2 → NP_001005868.1 erbin isoform 1

See identical proteins and their annotated locations for NP_001005868.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI428433, AK029054, AK051733, AK169529, BC145498, BM933013

Consensus CDS

CCDS26744.1

UniProtKB/TrEMBL

B2RUK2, B7ZNY4

Related

ENSMUSP00000140536.2, ENSMUST00000191275.7

Conserved Domains (5) summary

COG4886
Location:70 → 418

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:48 → 209

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1359 → 1445

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:368 → 411

LRR_4; Leucine Rich repeats (2 copies)
NM_001289473.1 → NP_001276402.1 erbin isoform 3

See identical proteins and their annotated locations for NP_001276402.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AI428433, AK029054, AK051733, AK169529, BC145498, BM933013

Consensus CDS

CCDS79233.1

UniProtKB/Swiss-Prot

E9QND6, Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47

UniProtKB/TrEMBL

B7ZNY4

Related

ENSMUSP00000088813.5, ENSMUST00000091269.11

Conserved Domains (5) summary

COG4886
Location:70 → 418

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:48 → 209

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1311 → 1397

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:368 → 411

LRR_4; Leucine Rich repeats (2 copies)
NM_001289474.1 → NP_001276403.1 erbin isoform 4

See identical proteins and their annotated locations for NP_001276403.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks three in-frame exons in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AI428433, AK051733, AK169529, BC141178, BM933013

Consensus CDS

CCDS79232.1

UniProtKB/TrEMBL

B2RUJ2, B7ZNY4

Related

ENSMUSP00000140931.2, ENSMUST00000188997.7

Conserved Domains (5) summary

COG4886
Location:70 → 418

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:48 → 209

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1204 → 1289

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:368 → 411

LRR_4; Leucine Rich repeats (2 copies)
NM_001289475.1 → NP_001276404.1 erbin isoform 5

See identical proteins and their annotated locations for NP_001276404.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 5), compared to isoform 1.

Source sequence(s)

AI428433, AK051733, AK169529, BC145498, BM933013

Consensus CDS

CCDS79234.1

UniProtKB/TrEMBL

B7ZNX6, B7ZNY4

Related

ENSMUSP00000127607.2, ENSMUST00000169083.8

Conserved Domains (5) summary

COG4886
Location:70 → 418

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:48 → 209

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1320 → 1406

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:368 → 411

LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

103955294..104057094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021563.2: Suppressed sequence

Description

NM_021563.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.