U.S. flag

An official website of the United States government

Erbin Erbb2 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 59079, updated on 9-Dec-2024

Summary

Official Symbol
Erbinprovided by MGI
Official Full Name
Erbb2 interacting proteinprovided by MGI
Primary source
MGI:MGI:1890169
See related
Ensembl:ENSMUSG00000021709 AllianceGenome:MGI:1890169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erbb2ip; mKIAA1225; 1700028E05Rik
Summary
Predicted to enable signaling receptor binding activity. Involved in negative regulation of monocyte chemotactic protein-1 production; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within protein targeting. Located in basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in cerebral cortex and retina nuclear layer. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 12.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Erbin in Genome Data Viewer
Location:
13 D1; 13 56.16 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (103955294..104057094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (103818786..103920586, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30551 Neighboring gene peptidylprolyl isomerase A pseudogene 13_1282.1 Neighboring gene STARR-seq mESC enhancer starr_35521 Neighboring gene STARR-seq mESC enhancer starr_35522 Neighboring gene STARR-positive B cell enhancer ABC_E9155 Neighboring gene STARR-positive B cell enhancer ABC_E11783 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1 Neighboring gene predicted gene, 52054 Neighboring gene STARR-seq mESC enhancer starr_35523 Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene STARR-positive B cell enhancer ABC_E8543 Neighboring gene STARR-seq mESC enhancer starr_35524 Neighboring gene STARR-seq mESC enhancer starr_35525 Neighboring gene STARR-seq mESC enhancer starr_35526 Neighboring gene STARR-seq mESC enhancer starr_35527 Neighboring gene STARR-seq mESC enhancer starr_35528 Neighboring gene STARR-seq mESC enhancer starr_35530 Neighboring gene predicted gene, 30967 Neighboring gene STARR-positive B cell enhancer mm9_chr13:104881886-104882187 Neighboring gene neurolysin (metallopeptidase M3 family) Neighboring gene STARR-positive B cell enhancer ABC_E3099 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding PubMed 
enables signaling receptor binding  
enables signaling receptor binding  
Process Evidence Code Pubs
involved_in cellular response to tumor necrosis factor  
involved_in cellular response to tumor necrosis factor  
involved_in intracellular signal transduction  
involved_in negative regulation of NF-kappaB transcription factor activity  
involved_in negative regulation of monocyte chemotactic protein-1 production PubMed 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway PubMed 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  
acts_upstream_of_or_within protein targeting PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in response to lipopolysaccharide  
involved_in response to lipopolysaccharide  
involved_in response to muramyl dipeptide  
involved_in response to muramyl dipeptide  
Component Evidence Code Pubs
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in cell junction  
located_in cytoplasm  
located_in cytoplasm  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in hemidesmosome  
located_in hemidesmosome  
located_in neuromuscular junction  
is_active_in neuromuscular junction  
located_in nuclear membrane  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleus  
located_in plasma membrane  
is_active_in postsynapse PubMed 
located_in postsynaptic specialization  
is_active_in postsynaptic specialization  

General protein information

Preferred Names
erbin
Names
densin-180-like protein
erbb2-interacting protein
protein LAP2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005868.2NP_001005868.1  erbin isoform 1

    See identical proteins and their annotated locations for NP_001005868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI428433, AK029054, AK051733, AK169529, BC145498, BM933013
    Consensus CDS
    CCDS26744.1
    UniProtKB/TrEMBL
    B2RUK2, B7ZNY4
    Related
    ENSMUSP00000140536.2, ENSMUST00000191275.7
    Conserved Domains (5) summary
    COG4886
    Location:70418
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:48209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:13591445
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:2447
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:368411
    LRR_4; Leucine Rich repeats (2 copies)
  2. NM_001289473.1NP_001276402.1  erbin isoform 3

    See identical proteins and their annotated locations for NP_001276402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI428433, AK029054, AK051733, AK169529, BC145498, BM933013
    Consensus CDS
    CCDS79233.1
    UniProtKB/Swiss-Prot
    E9QND6, Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47
    UniProtKB/TrEMBL
    B7ZNY4
    Related
    ENSMUSP00000088813.5, ENSMUST00000091269.11
    Conserved Domains (5) summary
    COG4886
    Location:70418
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:48209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:13111397
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:2447
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:368411
    LRR_4; Leucine Rich repeats (2 copies)
  3. NM_001289474.1NP_001276403.1  erbin isoform 4

    See identical proteins and their annotated locations for NP_001276403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three in-frame exons in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AI428433, AK051733, AK169529, BC141178, BM933013
    Consensus CDS
    CCDS79232.1
    UniProtKB/TrEMBL
    B2RUJ2, B7ZNY4
    Related
    ENSMUSP00000140931.2, ENSMUST00000188997.7
    Conserved Domains (5) summary
    COG4886
    Location:70418
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:48209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:12041289
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:2447
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:368411
    LRR_4; Leucine Rich repeats (2 copies)
  4. NM_001289475.1NP_001276404.1  erbin isoform 5

    See identical proteins and their annotated locations for NP_001276404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 5), compared to isoform 1.
    Source sequence(s)
    AI428433, AK051733, AK169529, BC145498, BM933013
    Consensus CDS
    CCDS79234.1
    UniProtKB/TrEMBL
    B7ZNX6, B7ZNY4
    Related
    ENSMUSP00000127607.2, ENSMUST00000169083.8
    Conserved Domains (5) summary
    COG4886
    Location:70418
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:48209
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00992
    Location:13201406
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00033
    Location:2447
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:368411
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    103955294..104057094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

External link. Please review our privacy policy.