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Cltb clathrin light chain B [ Mus musculus (house mouse) ]

Gene ID: 74325, updated on 17-Mar-2024

Summary

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Official Symbol
Cltbprovided by MGI
Official Full Name
clathrin light chain Bprovided by MGI
Primary source
MGI:MGI:1921575
See related
Ensembl:ENSMUSG00000047547 AllianceGenome:MGI:1921575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lcb; 2310046E19Rik
Summary
Predicted to enable clathrin heavy chain binding activity and peptide binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in ciliary membrane and trans-Golgi network. Is expressed in central nervous system; dorsal root ganglion; liver; and neural retina. Orthologous to human CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 62.4), frontal lobe adult (RPKM 47.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 28.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54740199..54759186, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54592386..54611373, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E927 Neighboring gene NOP16 nucleolar protein Neighboring gene HIG1 domain family, member 2A Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene ring finger protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E3083

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. Redlingshöfer L, et al. Proc Natl Acad Sci U S A, 2020 Sep 22. PMID 32907943, Free PMC Article
  2. The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia. Molla-Herman A, et al. J Cell Sci, 2010 May 15. PMID 20427320
  3. Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen. Gupta A, et al. Int J Biol Macromol, 2014 Aug. PMID 24780566
  4. Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension. Biancospino M, et al. Nat Commun, 2019 Oct 31. PMID 31672988, Free PMC Article
  5. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. Kamiya K, et al. J Clin Invest, 2014 Apr. PMID 24590285, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation.
    Title: Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic endocytic zone cytoplasmic component IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
clathrin light chain B
Names
clathrin, light polypeptide (Lcb)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347512.1 → NP_001334441.1  clathrin light chain B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK167531, BC070404, BE991851, BQ173953, BY075785, BY256386
    Consensus CDS
    CCDS84024.1
    UniProtKB/Swiss-Prot
    Q6IRU5, Q8BR04, Q8CDX9, Q9CV35
    UniProtKB/TrEMBL
    Q3TJ95
    Related
    ENSMUSP00000053371.8, ENSMUST00000049575.8

  2. NM_028870.4 → NP_083146.1  clathrin light chain B isoform b

    See identical proteins and their annotated locations for NP_083146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK159480, BE991851, BQ173953, BY075785, BY256386
    Consensus CDS
    CCDS26533.1
    UniProtKB/TrEMBL
    Q3TJ95, Q3TWZ9
    Related
    ENSMUSP00000089198.5, ENSMUST00000091609.11
    Conserved Domains (1) summary
    pfam01086
    Location:1 → 208
    Clathrin_lg_ch; Clathrin light chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    54740199..54759186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IRU5.1 GenPept UniProtKB/Swiss-Prot:Q6IRU5

Gene LinkOut

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