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Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 330064, updated on 11-Apr-2024

Summary

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Official Symbol
Slc5a6provided by MGI
Official Full Name
solute carrier family 5 (sodium-dependent vitamin transporter), member 6provided by MGI
Primary source
MGI:MGI:2660847
See related
Ensembl:ENSMUSG00000006641 AllianceGenome:MGI:2660847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430023I20
Summary
Predicted to enable biotin transmembrane transporter activity; pantothenate transmembrane transporter activity; and sodium-dependent multivitamin transmembrane transporter activity. Predicted to be involved in anion transmembrane transport; sodium ion transport; and transport across blood-brain barrier. Predicted to act upstream of or within ion transport. Predicted to be located in brush border membrane and vesicle membrane. Is expressed in several structures, including 4-cell stage embryo; choroid plexus; pericardium; pituitary gland; and skeletal musculature. Orthologous to human SLC5A6 (solute carrier family 5 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 20.8), large intestine adult (RPKM 17.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 16.93 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31193380..31206268, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31036036..31048924, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene predicted gene, 38601

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota. Sabui S, et al. Am J Physiol Gastrointest Liver Physiol, 2019 Oct 1. PMID 31369292, Free PMC Article
  2. Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects. Sabui S, et al. Am J Physiol Cell Physiol, 2018 Jul 1. PMID 29669219, Free PMC Article
  3. Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity. Sabui S, et al. Am J Physiol Gastrointest Liver Physiol, 2016 Sep 1. PMID 27492331, Free PMC Article
  4. Chronic alcohol exposure inhibits biotin uptake by pancreatic acinar cells: possible involvement of epigenetic mechanisms. Srinivasan P, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Nov 1. PMID 25214397, Free PMC Article
  5. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Ghosal A, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Jan 1. PMID 23104561, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway.
    Title: Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway.
  2. S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines.
    Title: Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms.
  3. These studies also provide evidence for a casual association between SMVT function and normal intestinal health
    Title: Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109689

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables biotin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables iodide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monocarboxylate:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pantothenate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pantothenate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pantothenate:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sodium-dependent multivitamin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium-dependent multivitamin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sodium-dependent multivitamin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfur compound transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables vitamin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables vitamin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biotin import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in biotin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biotin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iodide transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pantothenate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pantothenate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent multivitamin transporter
Names
Na(+)-dependent multivitamin transporter
solute carrier family 5 member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177621.1 → NP_001171092.1  sodium-dependent multivitamin transporter

    See identical proteins and their annotated locations for NP_001171092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AK158896, BC085132
    Consensus CDS
    CCDS19169.1
    UniProtKB/Swiss-Prot
    Q5U4D8, Q8BTU3
    UniProtKB/TrEMBL
    Q3TY45
    Related
    ENSMUSP00000110316.2, ENSMUST00000114668.7
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001177622.1 → NP_001171093.1  sodium-dependent multivitamin transporter

    See identical proteins and their annotated locations for NP_001171093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    BC065061, BC085132
    Consensus CDS
    CCDS19169.1
    UniProtKB/Swiss-Prot
    Q5U4D8, Q8BTU3
    UniProtKB/TrEMBL
    Q3TY45
    Related
    ENSMUSP00000079291.2, ENSMUST00000080431.8
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001360022.1 → NP_001346951.1  sodium-dependent multivitamin transporter

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC109608
    Consensus CDS
    CCDS19169.1
    UniProtKB/Swiss-Prot
    Q5U4D8, Q8BTU3
    UniProtKB/TrEMBL
    Q3TY45
    Related
    ENSMUSP00000143993.2, ENSMUST00000202556.4
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_177870.5 → NP_808538.1  sodium-dependent multivitamin transporter

    See identical proteins and their annotated locations for NP_808538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC109608, AK161633, BC085132
    Consensus CDS
    CCDS19169.1
    UniProtKB/Swiss-Prot
    Q5U4D8, Q8BTU3
    UniProtKB/TrEMBL
    Q3TY45
    Related
    ENSMUSP00000143938.2, ENSMUST00000202520.4
    Conserved Domains (1) summary
    cl00456
    Location:23 → 548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31193380..31206268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4D8.2 GenPept UniProtKB/Swiss-Prot:Q5U4D8

Gene LinkOut

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