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Dlgap1 DLG associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 224997, updated on 5-Mar-2024

Summary

Official Symbol
Dlgap1provided by MGI
Official Full Name
DLG associated protein 1provided by MGI
Primary source
MGI:MGI:1346065
See related
Ensembl:ENSMUSG00000003279 AllianceGenome:MGI:1346065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gkap; Sapap1; mKIAA4162; 9630002F18; GKAP/SAPAP; GKPA/SAPAP; D17Bwg0511e; 4933422O14Rik
Summary
Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within chemical synaptic transmission. Located in postsynaptic density. Is expressed in hippocampus. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 40.8), cortex adult (RPKM 32.3) and 6 other tissues See more
Orthologs
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Genomic context

Location:
17 E1.3; 17 40.85 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (70276068..71128408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69969073..70821413)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43132 Neighboring gene predicted gene, 36594 Neighboring gene programmed cell death 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43133 Neighboring gene stathmin 1, related sequence 2 Neighboring gene STARR-seq mESC enhancer starr_43136 Neighboring gene dephospho-CoA kinase domain containing pseudogene Neighboring gene predicted gene, 46581 Neighboring gene predicted gene, 36746 Neighboring gene STARR-seq mESC enhancer starr_43142 Neighboring gene STARR-seq mESC enhancer starr_43143 Neighboring gene STARR-seq mESC enhancer starr_43144 Neighboring gene STARR-positive B cell enhancer ABC_E9441 Neighboring gene STARR-seq mESC enhancer starr_43149 Neighboring gene STARR-seq mESC enhancer starr_43152 Neighboring gene STARR-seq mESC enhancer starr_43157 Neighboring gene predicted gene, 41609 Neighboring gene STARR-seq mESC enhancer starr_43159 Neighboring gene STARR-positive B cell enhancer ABC_E8692 Neighboring gene STARR-positive B cell enhancer ABC_E7553 Neighboring gene predicted gene, 41610 Neighboring gene TGFB-induced factor homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4162

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aggresome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disks large-associated protein 1
Names
DAP-1 beta
PSD-95/SAP90-binding protein 1
SAP90/PSD-95 associated protein 1
discs, large homolog-associated protein 1
guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128180.1NP_001121652.1  disks large-associated protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC079441, AC154769, AC163902
    Consensus CDS
    CCDS50172.1
    UniProtKB/TrEMBL
    E9QAR5, Q3TSN1
    Related
    ENSMUSP00000122337.2, ENSMUST00000148486.8
    Conserved Domains (1) summary
    pfam03359
    Location:350682
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. NM_001128181.1NP_001121653.1  disks large-associated protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001121653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes alternate exons in the 5' and 3' ends of the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 4 which is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC079441, AC163902
    Consensus CDS
    CCDS50173.1
    UniProtKB/TrEMBL
    A0A3B2W7Z1, Q3UVU8
    Related
    ENSMUSP00000094890.3, ENSMUST00000097288.4
    Conserved Domains (1) summary
    pfam03359
    Location:352618
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. NM_001347411.1NP_001334340.1  disks large-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
    Consensus CDS
    CCDS84331.1
    UniProtKB/TrEMBL
    D3Z709
    Related
    ENSMUSP00000118497.2, ENSMUST00000135938.8
  4. NM_001347412.1NP_001334341.1  disks large-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
    Consensus CDS
    CCDS84332.1
    UniProtKB/TrEMBL
    D3Z709, Q3UHD8
    Related
    ENSMUSP00000116716.2, ENSMUST00000133983.8
    Conserved Domains (1) summary
    pfam03359
    Location:650982
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. NM_001347413.1NP_001334342.1  disks large-associated protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC079441, AC154769, AC163902, AI837331
    Consensus CDS
    CCDS84333.1
    UniProtKB/TrEMBL
    D3Z508, Q3TSN1
    Related
    ENSMUSP00000117358.2, ENSMUST00000140728.8
  6. NM_001347414.1NP_001334343.1  disks large-associated protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC079441, AC154769, AC163902, AI837331
    Consensus CDS
    CCDS84334.1
    UniProtKB/TrEMBL
    D3Z6F4, Q3TSN1
    Related
    ENSMUSP00000122370.2, ENSMUST00000133717.9
  7. NM_001360665.1NP_001347594.1  disks large-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC079441, AC154604, AC154769, AC163902, AC165424, AC168117
    Consensus CDS
    CCDS84332.1
    UniProtKB/TrEMBL
    D3Z709, Q3UHD8
    Related
    ENSMUSP00000052858.6, ENSMUST00000060072.12
    Conserved Domains (1) summary
    pfam03359
    Location:650982
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  8. NM_027712.3NP_081988.3  disks large-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154769, BC094369
    UniProtKB/TrEMBL
    D3Z709
    Related
    ENSMUSP00000116072.2, ENSMUST00000146730.9
    Conserved Domains (1) summary
    pfam03359
    Location:650916
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  9. NM_177639.6NP_808307.2  disks large-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_808307.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079441, AC154769, AC163902
    Consensus CDS
    CCDS28953.1
    UniProtKB/Swiss-Prot
    Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
    UniProtKB/TrEMBL
    D3Z709
    Related
    ENSMUSP00000122896.2, ENSMUST00000155016.8
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    70276068..71128408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160564.1XP_036016457.1  disks large-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    D3Z709, Q3UHD8
    Conserved Domains (1) summary
    pfam03359
    Location:650982
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. XM_036160565.1XP_036016458.1  disks large-associated protein 1 isoform X7

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:622954
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. XM_006524173.3XP_006524236.1  disks large-associated protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006524236.1

    UniProtKB/Swiss-Prot
    Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  4. XM_036160562.1XP_036016455.1  disks large-associated protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. XM_011246406.3XP_011244708.1  disks large-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244708.1

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:6981030
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  6. XM_011246407.3XP_011244709.1  disks large-associated protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011244709.1

    UniProtKB/Swiss-Prot
    Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  7. XM_006524169.3XP_006524232.1  disks large-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524232.1

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:6981030
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  8. XM_030249738.1XP_030105598.1  disks large-associated protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  9. XM_036160563.1XP_036016456.1  disks large-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    D3Z709, Q3UHD8
    Conserved Domains (1) summary
    pfam03359
    Location:650982
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  10. XM_006524168.3XP_006524231.1  disks large-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524231.1

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:6981030
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  11. XM_006524172.3XP_006524235.1  disks large-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:6701002
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  12. XM_006524171.3XP_006524234.1  disks large-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:6881020
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  13. XM_006524174.3XP_006524237.1  disks large-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    D3Z709
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  14. XM_006524177.5XP_006524240.3  disks large-associated protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:431763
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  15. XM_006524178.5XP_006524241.3  disks large-associated protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:393725
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  16. XM_030249741.2XP_030105601.2  disks large-associated protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:365697
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  17. XM_030249739.2XP_030105599.2  disks large-associated protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:383715
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  18. XM_006524183.5XP_006524246.3  disks large-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A3B2WD59
    Related
    ENSMUSP00000156863.2, ENSMUST00000233283.2
    Conserved Domains (1) summary
    pfam03359
    Location:355687
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  19. XM_017317449.2XP_017172938.1  disks large-associated protein 1 isoform X19

    UniProtKB/TrEMBL
    Q3TSN1
    Conserved Domains (1) summary
    pfam03359
    Location:332664
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  20. XM_017317450.2XP_017172939.1  disks large-associated protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:322654
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  21. XM_006524181.1XP_006524244.1  disks large-associated protein 1 isoform X14

    UniProtKB/TrEMBL
    Q3TSN1
    Conserved Domains (1) summary
    pfam03359
    Location:362694
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  22. XM_006524185.1XP_006524248.1  disks large-associated protein 1 isoform X17

    UniProtKB/TrEMBL
    Q3TSN1
    Conserved Domains (1) summary
    pfam03359
    Location:352684
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  23. XM_036160566.1XP_036016459.1  disks large-associated protein 1 isoform X20

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:324656
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  24. XM_006524184.4XP_006524247.1  disks large-associated protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:352684
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  25. XM_036160567.1XP_036016460.1  disks large-associated protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:324656
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  26. XM_030249742.1XP_030105602.1  disks large-associated protein 1 isoform X18

    UniProtKB/TrEMBL
    Q3TSN1
    Conserved Domains (1) summary
    pfam03359
    Location:342674
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  27. XM_006524179.5XP_006524242.1  disks large-associated protein 1 isoform X10

    UniProtKB/TrEMBL
    Q3TSN1
    Conserved Domains (1) summary
    pfam03359
    Location:390722
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  28. XM_006524180.2XP_006524243.2  disks large-associated protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A3B2WD59
    Conserved Domains (1) summary
    pfam03359
    Location:343675
    GKAP; Guanylate-kinase-associated protein (GKAP) protein