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Abnormal urinary pyrimidine level

MedGen UID:
1734415
•Concept ID:
C5421653
•
Finding
HPO: HP:0033162

Definition

Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines. [from HPO]

Professional guidelines

PubMed

Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597

Recent clinical studies

Etiology

Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735Free PMC Article
Mode of action of pulegone on the urinary bladder of F344 rats.
Da Rocha MS, Dodmane PR, Arnold LL, Pennington KL, Anwar MM, Adams BR, Taylor SV, Wermes C, Adams TB, Cohen SM
Toxicol Sci 2012 Jul;128(1):1-8. Epub 2012 Apr 12 doi: 10.1093/toxsci/kfs135. PMID: 22499580
Henoch-Schönlein purpura with hypocomplementemia.
Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152

Diagnosis

Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735Free PMC Article
Henoch-Schönlein purpura with hypocomplementemia.
Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365
The importance of uric acid examination.
Sebesta I, Krijt J, Schneiderka P
Sb Lek 1994;95(4):383-9. PMID: 8867710
A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast.
Woo KB, Waalkes TP, Ahmann DL, Tormey DC, Gehrke CW, Oliverio VT
Cancer 1978 May;41(5):1685-703. doi: 10.1002/1097-0142(197805)41:5<1685::aid-cncr2820410507>3.0.co;2-9. PMID: 348295

Therapy

Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597
Switching Lamivudine with Adefovir Dipivoxil Combination Therapy to Entecavir Monotherapy Provides Better Viral Suppression and Kidney Safety.
Lian JS, Zhang XL, Lu YF, Chen JY, Zhang YM, Jia HY, Zhang Z, Yang YD
Int J Med Sci 2019;16(1):17-22. Epub 2019 Jan 1 doi: 10.7150/ijms.28700. PMID: 30662324Free PMC Article
Henoch-Schönlein purpura with hypocomplementemia.
Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152
Urinary excretion of beta-aminoisobutyrate and pseudouridine in acute and chronic myeloid leukemia.
Nielsen HR, Killmann SA
J Natl Cancer Inst 1983 Nov;71(5):887-91. PMID: 6580488

Prognosis

NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression.
Wang G, Zhang M, Zhang Y, Xie Y, Zou J, Zhong J, Zheng Z, Zhou X, Zheng Y, Chen B, Liu C
Clin Transl Med 2022 May;12(5):e738. doi: 10.1002/ctm2.738. PMID: 35522942Free PMC Article
Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course.
Kim K, Trott JF, Gao G, Chapman A, Weiss RH
BMC Nephrol 2019 Feb 25;20(1):66. doi: 10.1186/s12882-019-1249-6. PMID: 30803434Free PMC Article
Henoch-Schönlein purpura with hypocomplementemia.
Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X
Pediatr Nephrol 2012 May;27(5):801-6. Epub 2012 Jan 21 doi: 10.1007/s00467-011-2070-z. PMID: 22271365
Frequent alteration of p63 expression in human primary bladder carcinomas.
Park BJ, Lee SJ, Kim JI, Lee SJ, Lee CH, Chang SG, Park JH, Chi SG
Cancer Res 2000 Jul 1;60(13):3370-4. PMID: 10910040
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152

Clinical prediction guides

NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression.
Wang G, Zhang M, Zhang Y, Xie Y, Zou J, Zhong J, Zheng Z, Zhou X, Zheng Y, Chen B, Liu C
Clin Transl Med 2022 May;12(5):e738. doi: 10.1002/ctm2.738. PMID: 35522942Free PMC Article
Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M
Am Fam Physician 2020 Jun 15;101(12):721-729. PMID: 32538597
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Gevi F, Zolla L, Gabriele S, Persico AM
Mol Autism 2016;7:47. Epub 2016 Nov 24 doi: 10.1186/s13229-016-0109-5. PMID: 27904735Free PMC Article
Mode of action of pulegone on the urinary bladder of F344 rats.
Da Rocha MS, Dodmane PR, Arnold LL, Pennington KL, Anwar MM, Adams BR, Taylor SV, Wermes C, Adams TB, Cohen SM
Toxicol Sci 2012 Jul;128(1):1-8. Epub 2012 Apr 12 doi: 10.1093/toxsci/kfs135. PMID: 22499580
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Hayashi K, Kidouchi K, Sumi S, Mizokami M, Orito E, Kumada K, Ueda R, Wada Y
Clin Cancer Res 1996 Dec;2(12):1937-41. PMID: 9816152

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