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Elevated urinary uridine level

MedGen UID:
1712524
•Concept ID:
C5397601
•
Finding
Synonym: Elevated uridine in urine
 
HPO: HP:0032574

Definition

Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary uridine level

Conditions with this feature

Uridine-cytidineuria
MedGen UID:
1681582
•Concept ID:
C4760647
•
Finding
Uridine-cytidineuria (URCTU) is an inborn error of metabolism comprising increased excretion of the pyrimidine nucleosides. This condition has been identified incidentally and may be a benign metabolic phenotype (summary by Wevers et al., 2019).
See: Condition Record
Uridine-cytidineuria

Recent clinical studies

Etiology

Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a han chinese population.
Shen H, Xu W, Zhang J, Chen M, Martin FL, Xia Y, Liu L, Dong S, Zhu YG
Environ Sci Technol 2013 Aug 6;47(15):8843-51. Epub 2013 Jul 22 doi: 10.1021/es402025n. PMID: 23841501
Chemoprevention by inducers of carcinogen detoxication enzymes.
Kensler TW
Environ Health Perspect 1997 Jun;105 Suppl 4(Suppl 4):965-70. doi: 10.1289/ehp.97105s4965. PMID: 9255588Free PMC Article
Urinary excretion of pseudouridine and prognosis of patients with malignant lymphoma.
Rasmuson T, Björk GR
Acta Oncol 1995;34(1):61-7. doi: 10.3109/02841869509093640. PMID: 7865238
Urinary excretion of pseudouridine in patients with brain tumours.
Manjula S, Aroor AR, Raja A, Rao S, Rao A
Acta Oncol 1993;32(3):311-4. doi: 10.3109/02841869309093601. PMID: 8323769
Allopurinol challenge test in children.
Burlina AB, Ferrari V, Dionisi-Vici C, Bordugo A, Zacchello F, Tuchman M
J Inherit Metab Dis 1992;15(5):707-12. doi: 10.1007/BF01800010. PMID: 1434508

Diagnosis

Clinical value of urinary and serum pseudouridine in diagnosis and monitoring of primary liver cancer.
Tu Z, Xu S, Wu M
Chin Med J (Engl) 1995 Mar;108(3):204-8. PMID: 7796629
Allopurinol challenge test in children.
Burlina AB, Ferrari V, Dionisi-Vici C, Bordugo A, Zacchello F, Tuchman M
J Inherit Metab Dis 1992;15(5):707-12. doi: 10.1007/BF01800010. PMID: 1434508
Urinary pseudouridine as a biochemical marker in the diagnosis and monitoring of primary hepatocellular carcinoma.
Tamura S, Fujioka H, Nakano T, Amuro Y, Hada T, Nakao N, Higashino K
Am J Gastroenterol 1988 Aug;83(8):841-5. PMID: 2456010
Urinary excretion of pseudouridine in patients with hepatocellular carcinoma.
Tamura S, Amuro Y, Nakano T, Fujii J, Moriwaki Y, Yamamoto T, Hada T, Higashino K
Cancer 1986 Apr 15;57(8):1571-5. doi: 10.1002/1097-0142(19860415)57:8<1571::aid-cncr2820570822>3.0.co;2-r. PMID: 2418945
A quantitative approach to determining disease response during therapy using multiple biologic markers: application to carcinoma of the breast.
Woo KB, Waalkes TP, Ahmann DL, Tormey DC, Gehrke CW, Oliverio VT
Cancer 1978 May;41(5):1685-703. doi: 10.1002/1097-0142(197805)41:5<1685::aid-cncr2820410507>3.0.co;2-9. PMID: 348295

Therapy

Creatinine at the evaluation of urinary 1-methyladenosine and pseudouridine excretion.
Honda I, Itoh K, Mizugaki M, Sasaki T
Tohoku J Exp Med 1999 Jun;188(2):133-8. doi: 10.1620/tjem.188.133. PMID: 10526874
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
van Groeningen CJ, Leyva A, Kraal I, Peters GJ, Pinedo HM
Cancer Treat Rep 1986 Jun;70(6):745-50. PMID: 3731137
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Leyva A, van Groeningen CJ, Kraal I, Gall H, Peters GJ, Lankelma J, Pinedo HM
Cancer Res 1984 Dec;44(12 Pt 1):5928-33. PMID: 6498850
Urinary excretion of beta-aminoisobutyrate and pseudouridine in acute and chronic myeloid leukemia.
Nielsen HR, Killmann SA
J Natl Cancer Inst 1983 Nov;71(5):887-91. PMID: 6580488
Biological markers in breast carcinoma--clinical correlations with pseudouridine, N2,N2-dimethylguanosine, and 1-methylinosine.
Tormey DC, Waalkes TP, Gehrke CW
J Surg Oncol 1980;14(3):267-73. doi: 10.1002/jso.2930140313. PMID: 7392649

Prognosis

Urinary excretion of pseudouridine and prognosis of patients with malignant lymphoma.
Rasmuson T, Björk GR
Acta Oncol 1995;34(1):61-7. doi: 10.3109/02841869509093640. PMID: 7865238
Clinical value of urinary and serum pseudouridine in diagnosis and monitoring of primary liver cancer.
Tu Z, Xu S, Wu M
Chin Med J (Engl) 1995 Mar;108(3):204-8. PMID: 7796629
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
van Groeningen CJ, Leyva A, Kraal I, Peters GJ, Pinedo HM
Cancer Treat Rep 1986 Jun;70(6):745-50. PMID: 3731137
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Leyva A, van Groeningen CJ, Kraal I, Gall H, Peters GJ, Lankelma J, Pinedo HM
Cancer Res 1984 Dec;44(12 Pt 1):5928-33. PMID: 6498850
Biological markers in breast carcinoma--clinical correlations with pseudouridine, N2,N2-dimethylguanosine, and 1-methylinosine.
Tormey DC, Waalkes TP, Gehrke CW
J Surg Oncol 1980;14(3):267-73. doi: 10.1002/jso.2930140313. PMID: 7392649

Clinical prediction guides

Urinary excretion of pseudouridine and prognosis of patients with malignant lymphoma.
Rasmuson T, Björk GR
Acta Oncol 1995;34(1):61-7. doi: 10.3109/02841869509093640. PMID: 7865238
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
van Groeningen CJ, Leyva A, Kraal I, Peters GJ, Pinedo HM
Cancer Treat Rep 1986 Jun;70(6):745-50. PMID: 3731137
Reversed-phase high-performance liquid chromatographic investigation of mucosal nucleosides and bases and urinary modified nucleosides of gastrointestinal cancer patients.
Nakano K, Shindo K, Yasaka T, Yamamoto H
J Chromatogr 1985 Sep 13;343(1):21-33. doi: 10.1016/s0378-4347(00)84564-8. PMID: 4066857
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Leyva A, van Groeningen CJ, Kraal I, Gall H, Peters GJ, Lankelma J, Pinedo HM
Cancer Res 1984 Dec;44(12 Pt 1):5928-33. PMID: 6498850
Biological markers in breast carcinoma--clinical correlations with pseudouridine, N2,N2-dimethylguanosine, and 1-methylinosine.
Tormey DC, Waalkes TP, Gehrke CW
J Surg Oncol 1980;14(3):267-73. doi: 10.1002/jso.2930140313. PMID: 7392649

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