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Elevated urinary thymidine level

MedGen UID:
1053525
•Concept ID:
CN376637
•
Finding
HPO: HP:6000128

Definition

The amount of thymidine in the urine, normalized for urine concentration, is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary thymidine level

Recent clinical studies

Etiology

C-peptide induces human renal mesangial cell proliferation in vitro, activating Src-kinase, PI-3 kinase and ERK1/2.
Vasic D, Spyrantis A, Durst R, Bach H, Vogt S, Rottbauer W, Walcher D
Mol Cell Endocrinol 2012 Apr 4;351(2):337-41. Epub 2012 Jan 16 doi: 10.1016/j.mce.2012.01.011. PMID: 22269094
A cross-sectional investigation of biomarkers of risk after a decade of smoking.
Calapai G, Caputi AP, Mannucci C, Gregg EO, Pieratti A, Aurora Russo G, Chaudhary N, Puntoni R, Lowe F, McEwan M, Bassi A, Morandi S, Nunziata A
Inhal Toxicol 2009 Nov;21(13):1138-43. doi: 10.3109/08958370902798455. PMID: 19852556
5,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension.
Ravera M, Viazzi F, Berruti V, Leoncini G, Zagami P, Bezante GP, Rosatto N, Ravazzolo R, Pontremoli R, Deferrari G
Am J Hypertens 2001 Apr;14(4 Pt 1):371-6. doi: 10.1016/s0895-7061(00)01296-6. PMID: 11336184
Glucocorticoid receptors in anorexia nervosa and Cushing's disease.
Invitti C, Redaelli G, Baldi G, Cavagnini F
Biol Psychiatry 1999 Jun 1;45(11):1467-71. doi: 10.1016/s0006-3223(98)00189-9. PMID: 10356629
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Gronowitz JS, Larsson A, Källander CF, Claesson K, Sjöberg O, Lernestedt JO, Frödin L, Tufveson G
Ann Clin Res 1986;18(2):71-5. PMID: 3013074

Diagnosis

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
Cytotoxic activity of gemcitabine in cultured cell lines derived from histologically different types of bladder cancer: role of thymidine kinase 2.
Damaraju S, Damaraju VL, Mowles D, Sawyer MB, Damaraju S, Cass CE
Biochem Pharmacol 2010 Jan 1;79(1):21-9. Epub 2009 Aug 4 doi: 10.1016/j.bcp.2009.07.018. PMID: 19660438
Thymidine phosphorylase expression as a prognostic marker for predicting recurrence in primary superficial bladder cancer.
Aoki S, Yamada Y, Nakamura K, Taki T, Tobiume M, Honda N
Oncol Rep 2006 Aug;16(2):279-84. PMID: 16820903
Glucocorticoid receptors in anorexia nervosa and Cushing's disease.
Invitti C, Redaelli G, Baldi G, Cavagnini F
Biol Psychiatry 1999 Jun 1;45(11):1467-71. doi: 10.1016/s0006-3223(98)00189-9. PMID: 10356629
Primary cortisol resistance associated with a thermolabile glucocorticoid receptor in a patient with fatigue as the only symptom.
Brönnegård M, Werner S, Gustafsson JA
J Clin Invest 1986 Nov;78(5):1270-8. doi: 10.1172/JCI112711. PMID: 3771797Free PMC Article

Therapy

Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
Thu AM, Poovorawan K, Kittitrakul C, Nontprasert A, Sriboonvorakul N, Phumratanaprapin W, Tangkijvanich P, Leowattana W, Wilairatana P
BMC Pharmacol Toxicol 2015 Dec 14;16:38. doi: 10.1186/s40360-015-0037-6. PMID: 26651337Free PMC Article
A cross-sectional investigation of biomarkers of risk after a decade of smoking.
Calapai G, Caputi AP, Mannucci C, Gregg EO, Pieratti A, Aurora Russo G, Chaudhary N, Puntoni R, Lowe F, McEwan M, Bassi A, Morandi S, Nunziata A
Inhal Toxicol 2009 Nov;21(13):1138-43. doi: 10.3109/08958370902798455. PMID: 19852556
Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.
Thier R, Brüning T, Kocher K, Blaszkewicz M, Makropoulos V, Sundberg A, Bolt HM
Arch Toxicol 1999 Nov;73(8-9):479-84. doi: 10.1007/s002040050638. PMID: 10650920
Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions.
Burger DM, Meenhorst PL, ten Napel CH, Mulder JW, Neef C, Koks CH, Bult A, Beijnen JH
AIDS 1994 Dec;8(12):1683-9. doi: 10.1097/00002030-199412000-00007. PMID: 7888117
Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal transplant rejection and its use for monitoring of antiviral therapy.
Gronowitz JS, Larsson A, Källander CF, Claesson K, Sjöberg O, Lernestedt JO, Frödin L, Tufveson G
Ann Clin Res 1986;18(2):71-5. PMID: 3013074

Prognosis

Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
Thu AM, Poovorawan K, Kittitrakul C, Nontprasert A, Sriboonvorakul N, Phumratanaprapin W, Tangkijvanich P, Leowattana W, Wilairatana P
BMC Pharmacol Toxicol 2015 Dec 14;16:38. doi: 10.1186/s40360-015-0037-6. PMID: 26651337Free PMC Article
Thymidine phosphorylase expression as a prognostic marker for predicting recurrence in primary superficial bladder cancer.
Aoki S, Yamada Y, Nakamura K, Taki T, Tobiume M, Honda N
Oncol Rep 2006 Aug;16(2):279-84. PMID: 16820903
Development of human chorionic gonadotropin subunit-beta promoter-based toxic gene therapy for testicular cancer.
Shirakawa T, Gotoh A, Zhang Z, Kao C, Chung LW, Gardner TA
Urology 2004 Mar;63(3):613-8. doi: 10.1016/j.urology.2003.09.054. PMID: 15028478
The significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor activity in renal cell carcinoma.
Mizutani Y, Wada H, Yoshida O, Fukushima M, Kawauchi A, Nakao M, Miki T
Cancer 2003 Aug 15;98(4):730-6. doi: 10.1002/cncr.11570. PMID: 12910516
Prognostic significance of thymidine kinase activity in bladder carcinoma.
Mizutani Y, Wada H, Yoshida O, Fukushima M, Kamoi K, Miki T
Cancer 2002 Nov 15;95(10):2120-5. doi: 10.1002/cncr.10948. PMID: 12412165

Clinical prediction guides

Laboratory and metabolic investigations.
Morava E, Oglesbee D
Handb Clin Neurol 2023;194:167-172. doi: 10.1016/B978-0-12-821751-1.00012-9. PMID: 36813311
A cross-sectional investigation of biomarkers of risk after a decade of smoking.
Calapai G, Caputi AP, Mannucci C, Gregg EO, Pieratti A, Aurora Russo G, Chaudhary N, Puntoni R, Lowe F, McEwan M, Bassi A, Morandi S, Nunziata A
Inhal Toxicol 2009 Nov;21(13):1138-43. doi: 10.3109/08958370902798455. PMID: 19852556
Prognostic significance of thymidine kinase activity in bladder carcinoma.
Mizutani Y, Wada H, Yoshida O, Fukushima M, Kamoi K, Miki T
Cancer 2002 Nov 15;95(10):2120-5. doi: 10.1002/cncr.10948. PMID: 12412165
Determination of urinary thymidine glycol using affinity chromatography, HPLC and post-column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation.
Thier R, Brüning T, Kocher K, Blaszkewicz M, Makropoulos V, Sundberg A, Bolt HM
Arch Toxicol 1999 Nov;73(8-9):479-84. doi: 10.1007/s002040050638. PMID: 10650920
Effect of elevated glucose concentrations on cellular lipid peroxidation and growth of cultured human kidney proximal tubule cells.
Jain SK, Morshed KM, Kannan K, McMartin KE, Bocchini JA Jr
Mol Cell Biochem 1996 Sep 6;162(1):11-6. doi: 10.1007/BF00250990. PMID: 8905620

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