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    JKAMP JNK1/MAPK8 associated membrane protein [ Homo sapiens (human) ]

    Gene ID: 51528, updated on 3-Apr-2024

    Summary

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    Official Symbol
    JKAMPprovided by HGNC
    Official Full Name
    JNK1/MAPK8 associated membrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:20184
    See related
    Ensembl:ENSG00000050130 MIM:611176; AllianceGenome:HGNC:20184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAMP; CDA06; HSPC213; HSPC327; C14orf100; C24orf100
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 16.2), adrenal (RPKM 14.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59484517..59505410)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (53691449..53712359)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59951235..59972128)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5803 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59655908-59656667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8458 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34577 Neighboring gene Sharpr-MPRA regulatory region 14842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5805 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8459 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:59797736-59798544 Neighboring gene NANOG hESC enhancer GRCh37_chr14:59862330-59862839 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8461 Neighboring gene uncharacterized LOC124903326 Neighboring gene G protein-coupled receptor 135 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene coiled-coil domain containing 175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene leucine rich repeat containing 9 Neighboring gene PCNX4 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. JAMP optimizes ERAD to protect cells from unfolded proteins. Tcherpakov M, et al. Mol Biol Cell, 2008 Nov. PMID 18784250, Free PMC Article
    2. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Cubero FJ, et al. J Hepatol, 2015 Jan. PMID 25173965
    3. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Kadoya T, et al. Mol Cell Biol, 2005 Oct. PMID 16166642, Free PMC Article
    4. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). Tcherpakov M, et al. J Biol Chem, 2009 May 1. PMID 19269966, Free PMC Article
    5. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Behrends U, et al. Int J Cancer, 2003 Aug 20. PMID 12800201

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. synergistic function of Jnk1 in haematopoietic cells and hepatocytes might be relevant for the development of chronic liver injury
      Title: Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury.
    2. Expression of DP, a receptor largely retained in the ER, promoted proteasome recruitment by JAMP.
      Title: Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP.
      Title: Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).
    5. JAMP is an important component for coordinated clearance of misfolded proteins from the endoplasmic reticulum.
      Title: JAMP optimizes ERAD to protect cells from unfolded proteins.
    6. Identification and functional characterization of the mouse Jamp ortholog.
      Title: JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46787

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    JNK1/MAPK8-associated membrane protein
    Names
    JNK-associated membrane protein
    Jun N-terminal kinase 1-associated membrane protein
    medulloblastoma antigen MU-MB-50.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098625.3 → NP_001092095.1  JNK1/MAPK8-associated membrane protein isoform 2

      See identical proteins and their annotated locations for NP_001092095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL121694, BC005198, BX161501, HY340214
      Consensus CDS
      CCDS45117.1
      UniProtKB/TrEMBL
      B3KPC2
      Related
      ENSP00000389699.2, ENST00000425728.6
      Conserved Domains (1) summary
      pfam05571
      Location:3 → 294
      DUF766; Protein of unknown function (DUF766)

    2. NM_001284201.2 → NP_001271130.1  JNK1/MAPK8-associated membrane protein isoform 3

      See identical proteins and their annotated locations for NP_001271130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK056145, AL121694, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS61462.1
      UniProtKB/TrEMBL
      B3KPC2, G3V2M4
      Related
      ENSP00000450749.1, ENST00000554271.5
      Conserved Domains (1) summary
      pfam05571
      Location:23 → 314
      DUF766; Protein of unknown function (DUF766)

    3. NM_001284202.2 → NP_001271131.1  JNK1/MAPK8-associated membrane protein isoform 4 precursor

      See identical proteins and their annotated locations for NP_001271131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL121694, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS61463.1
      UniProtKB/TrEMBL
      B3KPC2
      Related
      ENSP00000348351.5, ENST00000356057.9
      Conserved Domains (1) summary
      pfam05571
      Location:17 → 308
      DUF766; Protein of unknown function (DUF766)

    4. NM_001284203.2 → NP_001271132.1  JNK1/MAPK8-associated membrane protein isoform 5

      See identical proteins and their annotated locations for NP_001271132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298209, AL121694, BX161501, DC381037, HY340214
      Related
      ENST00000602482.5
      Conserved Domains (1) summary
      pfam05571
      Location:1 → 237
      DUF766; Protein of unknown function (DUF766)

    5. NM_001284204.2 → NP_001271133.1  JNK1/MAPK8-associated membrane protein isoform 6

      See identical proteins and their annotated locations for NP_001271133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AF212245, AL121694, BU928810, BX161501, HY340214
      UniProtKB/TrEMBL
      G3V2R2
      Conserved Domains (1) summary
      pfam05571
      Location:9 → 213
      DUF766; Protein of unknown function (DUF766)

    6. NM_016475.5 → NP_057559.2  JNK1/MAPK8-associated membrane protein isoform 1

      See identical proteins and their annotated locations for NP_057559.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL121694, AL136696, BX161501, DC381037, HY340214
      Consensus CDS
      CCDS45116.1
      UniProtKB/Swiss-Prot
      B4DP67, Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P055, Q9P0R3
      UniProtKB/TrEMBL
      B3KPC2
      Related
      ENSP00000479775.2, ENST00000616435.5
      Conserved Domains (1) summary
      pfam05571
      Location:9 → 300
      DUF766; Protein of unknown function (DUF766)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      59484517..59505410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449627.2 → XP_024305395.1  JNK1/MAPK8-associated membrane protein isoform X1

      UniProtKB/TrEMBL
      B3KPC2, G3V2M4
      Conserved Domains (1) summary
      pfam05571
      Location:23 → 314
      DUF766; Protein of unknown function (DUF766)

    2. XM_047431467.1 → XP_047287423.1  JNK1/MAPK8-associated membrane protein isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      53691449..53712359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376204.1 → XP_054232179.1  JNK1/MAPK8-associated membrane protein isoform X1

      UniProtKB/TrEMBL
      G3V2M4

    2. XM_054376205.1 → XP_054232180.1  JNK1/MAPK8-associated membrane protein isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P055.4 GenPept UniProtKB/Swiss-Prot:Q9P055

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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