NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|545746318|ref|NP_001271133|]
View 

JNK1/MAPK8-associated membrane protein isoform 6 [Homo sapiens]

Protein Classification

JKAMP family protein( domain architecture ID 8567)

JNK1/MAPK8-associated membrane protein (JKAMP) family protein, formerly called DUF766 domain, similar to human JKAMP which may be a regulator of the duration of MAPK8 activity in response to various stress stimuli

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
JAMP super family cl05243
JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins ...
 9-213 3.22e-110

JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins including JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli. It is an important component for coordinated clearance of misfolded proteins from the ER.


The actual alignment was detected with superfamily member pfam05571:

Pssm-ID: 398936  Cd Length: 292  Bit Score: 317.26  E-value: 3.22e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318    9 CLGLYCGKTLLFKNGsteiYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSS-- 86
Cdd:pfam05571   1 CPGLYCGRTLLENGT----WSECGACPRGYRVNASSICQPCTDSPELYDWLYLGFMALLPLVLHWFFIDMTSKYRRFSkk 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318   87 ALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV 166
Cdd:pfam05571  77 VIILHLSALIEIVLAALITLLVYEPIGSLTLNSCRVRRLSDWYTLFYNPSPDYETTLHCTQEAVYPLYSIVFIFYALCLV 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 545746318  167 LMMLLRPLLVKKiaCGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 213
Cdd:pfam05571 157 LMLLIRPLLYSK--FLLRKGKNTKSIYAALYFFPILALIHAVLGGLI 201
 
Name Accession Description Interval E-value
JAMP pfam05571
JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins ...
 9-213 3.22e-110

JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins including JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli. It is an important component for coordinated clearance of misfolded proteins from the ER.


Pssm-ID: 398936  Cd Length: 292  Bit Score: 317.26  E-value: 3.22e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318    9 CLGLYCGKTLLFKNGsteiYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSS-- 86
Cdd:pfam05571   1 CPGLYCGRTLLENGT----WSECGACPRGYRVNASSICQPCTDSPELYDWLYLGFMALLPLVLHWFFIDMTSKYRRFSkk 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318   87 ALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV 166
Cdd:pfam05571  77 VIILHLSALIEIVLAALITLLVYEPIGSLTLNSCRVRRLSDWYTLFYNPSPDYETTLHCTQEAVYPLYSIVFIFYALCLV 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 545746318  167 LMMLLRPLLVKKiaCGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 213
Cdd:pfam05571 157 LMLLIRPLLYSK--FLLRKGKNTKSIYAALYFFPILALIHAVLGGLI 201
 
Name Accession Description Interval E-value
JAMP pfam05571
JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins ...
 9-213 3.22e-110

JNK1/MAPK8-associated membrane protein; This family consists of several eukaryotic proteins including JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli. It is an important component for coordinated clearance of misfolded proteins from the ER.


Pssm-ID: 398936  Cd Length: 292  Bit Score: 317.26  E-value: 3.22e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318    9 CLGLYCGKTLLFKNGsteiYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSS-- 86
Cdd:pfam05571   1 CPGLYCGRTLLENGT----WSECGACPRGYRVNASSICQPCTDSPELYDWLYLGFMALLPLVLHWFFIDMTSKYRRFSkk 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746318   87 ALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLV 166
Cdd:pfam05571  77 VIILHLSALIEIVLAALITLLVYEPIGSLTLNSCRVRRLSDWYTLFYNPSPDYETTLHCTQEAVYPLYSIVFIFYALCLV 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 545746318  167 LMMLLRPLLVKKiaCGLGKSDRFKSIYAALYFFPILTVLQAVGGGLL 213
Cdd:pfam05571 157 LMLLIRPLLYSK--FLLRKGKNTKSIYAALYFFPILALIHAVLGGLI 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH