Conserved Protein Domain Family
JAMP

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pfam05571: JAMP 
JNK1/MAPK8-associated membrane protein
This family consists of several eukaryotic proteins including JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli. It is an important component for coordinated clearance of misfolded proteins from the ER.
Statistics
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PSSM-Id: 398936
Aligned: 24 rows
Threshold Bit Score: 329.203
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD70268      15 CLG-FCGRTVLVGNYsedveatttaagstsLSRCGPCSFGYRNN-A-----------MSICESCDTPLQPYDWMYLLFIA 81 
XP_009024098   3 CLGlYCGRLLLGNGT---------------LSECGACPSGSRVNaS-----------SGICQECTNILSDYDWFYLLFMA 56 
XP_002109093  19 CTGkYCGRTVLENGQ---------------LTACGPCLCGFRPN-A-----------SGICQPCALPLIVYDWLFLLFMS 71 
XP_016656621  23 CPGyYCGRLDLGNGR---------------TSDCGSCPSGTKVN-S-----------IHICQQCTDSPSSYDFMYLLFMA 75 
XP_002130041   8 CSGrYCGRIKNESSG---------------WSDCTACPVGYRSD-D-----------LKLCQKCVDSPDLYEWMYLGFMA 60 
2_pfamImport   1 CTGrYCGRIKNDTNV---------------WGECTACPIGFRTD-E-----------LKLCQKCVNSPELYHWMYLGFMA 53 
XP_003388492  11 CPGmFCGRLNLTNSC---------------FSSCQACPRGYRVD-E-----------DSLCRPCDSPADPRDYLYLVFMG 63 
XP_002636815 236 CLG-FCGRSFISTNYseeat------stssLSQCGACSFGYRSN-A-----------TSICVPCETPLQAYDWMYLLFIA 296
XP_015788929   4 CPGiYCGRIIFDNDT---------------VSDCMSCPSGTRSStSypgysqvegkiQSLCIPCSLSFASNDWFYLGFMA 68 
XP_002610598  32 CPGiYCGKALLVNNT---------------YSQCGACPRGYISD-E-----------SSICQPCDDVPSFYDWLYLSFMV 84 
CCD70268      82 LLPLLLHMQFIRIA-------------RKYCR--TRYYEVSEYLCVILENVIACVIAVL-IYPPRFTFFLNGCSKTDIKE 145
XP_009024098  57 LLPLLSNYFFIDVT-------------SKNRFecDHCKNVTLHISATIEAAISLVITIL-SFQPIGTFTIKSCESTRLSD 122
XP_002109093  72 SFSLVLHFFFIDHY-------------VRTDS----KRLAIWHGSAIFEAIVSAIISIL-TSRPIGSLTLEGCGVKELSD 133
XP_016656621  76 TVPLLFHAVYIDLSlssilwafkgkngNSQKK---TKTKVVLNVSAILEIFIAAVSAVL-IVDPIGQLWIRSCRTQWLSD 151
XP_002130041  61 MLPLTLNWLCI----------------LIYNHkwSSPAVIIQMVSSFFESFTAAILSLL-IYEPRGSLTLLSCKVVQISD 123
2_pfamImport  54 ILPLSLNWLCI----------------LSNYSvwSSPAVIVQMISSFIESCMAALFALL-VYEPKGSLNLVSCPVVQISD 116
XP_003388492  64 LVMLFLRLGIVTFT-------------NWYKL--KSPVVIPFYVIPAIETTLSIIFTLL-VLPPQGSVGLNSCRVSSVND 127
XP_002636815 297 LLPLLLHMQFIRVA-------------RKYCR--TRYYEVSEYLCVILENVIACVISVL-IYPPRFSFFLNGCEKTGLKE 360
XP_015788929  69 LVLLVMEWYIIDHS-------------IRRRT--LPFEVLIIHLSALFEISLAALLTLLaFSTPIGSFNLKSCGAYRISD 133
XP_002610598  85 VASIILHWFFIDWF-------------SNRQN------IVLFYISALIECVGAALLTLV-MVEPVGTLSVRSCHTQRLSD 144
CCD70268     146 WYPACYNPRIGYTKTMRCTYEVVFPLYSITFIH--HLILIGsilvLRSTLYC-----VLLYKTYNGKPFYAAIVSVPILA 218
XP_009024098 123 WYTILYNPSPDFINTIHCTQQAVYPLYSMVFLM--YLLSLK----IRTSCVRwdnsfIDGKRRFCTCSLYSALFFHPAIA 196
XP_002109093 134 WYTIFYNPTIDYKITIHCAAEAVCPLYSIVLKY--YFIALIlmavARTMIASk----FNILGMK--KSIYAALYFFPLLI 205
XP_016656621 152 WYTVLYNPTPDYRESLRCTQEAVYPLYSMVFIF--YLACIIvlltIRPLLSAy----FNLNRGAYLKTIYAGLYFFPIAA 225
XP_002130041 124 WYTVFFNPTIKYTTTVFCAQEAVYPLYSIVFLC--YLFSLAmlvlLRPIAYSll--pKPSRNKLFTKTLYATLYFHPILV 199
2_pfamImport 117 WYTVFFNPTVKYTTTIFCGQEAVYPLYSIIFVC--YLLSLGlmvvIRPIAYYli--pRNLRTKMYTKTLYATLYLHPILV 192
XP_003388492 128 FYPIFFNPSVDYVHSLKCSYEVVYPLYSMVFIFlgWNFLLHlpflITALSYSyyawsKEKREYFSARTEYVWLIMYPFVL 207
XP_002636815 361 WYPACYNPKIGYTKTMRCTYEVVFPLYSITFVH--HMILMGaiftLRSILYC-----AMLYKAYNAKPYYLAIVSVPLLV 433
XP_015788929 134 WYTLFFNPSVNFKDTIRCAQEAVYPLYSMIFLF--YFLCLVhlitIRPWVIRw----VSDSKAP--NTIYLTLYVIPALT 205
XP_002610598 145 WYTMLYNPHPGYTSTLYCTQEAVYPLYTMVFMY--YAVSLClmllFRPLLSNr----LCKNKGA--ASIYAALYFIPILV 216
CCD70268     219 VIHAVLSGVVFYTFPYILLIGSLWAMCFHLALEGKRPLKEMIVRIATSPTHLIFLSITML-------MLSFGVIAIIApL 291
XP_009024098 197 CIHAVFAGVIYYSYPYIIVVGSVITNAIHFASYRNQTPVGLLKSLTTKPRNMVILMAHWL-------VHAFGIISLLS-S 268
XP_002109093 206 VTQAVLGGVLYFGFPYIVIVTATLTTAYTLAGNNVSSFLDVIKSK----RLTIITVVHWL-------ALAIGIAAATNgL 274
XP_016656621 226 IIHAFLGGIVYVTFPYIVIVVSVISSAIHFATEINQSAKYLIVNTVCVPRNILIVAVHWV-------SHGFGIVAITQ-L 297
XP_002130041 200 AVHAVCAGLLYYSYPYLTMFTTVLATVTYYVKCDAMTLKKILDKDLS--KHIFAMVWHLL-------TLCAAAVSIII-S 269
2_pfamImport 193 AIHAVFAGLIYYSFPYLTVLATMVAMVKYYVGCDAMTIQSIFGQGRG--QHIFVLIWHLL-------VLCAAVIPIIL-T 262
XP_003388492 208 LIHGTLAGLIYYTFDYVTIILAIGSFAV-----LSTSLHIYKFDDMKNTFKVYILGIEWLivigsiiLLSCGILSLTE-W 281
XP_002636815 434 MIHSVLSGLIFYSFPYILLIGSLWAMCFHLALEGKRPLKEMIVRLATSPTHWVFLTITML-------MLSFGVVALITpL 506
XP_015788929 206 ISHALFSGLIYYSFPFLTLVSSTISIAAHFAYRLDQSMSALFFKSFESIRSVIILFGHWL-------LHAYGIIALTK-F 277
XP_002610598 217 VIHAVGAGLIYYAFPYIVIVASVLTNAVYFAQRDIQNVRQIVRSK----RNILILCGHWI-------IHAFGIVAITG-L 284
CCD70268     292 DIP-YRWSFLC-IV--PVPFIFYMATIPFSNP 319
XP_009024098 269 NIKtNQLAYLC-LI--PTPCLVYVISVYFTDP 297
XP_002109093 275 KNPpIAAQVLLgLI--PLPLVFYIITYKFTNP 304
XP_016656621 298 ENPpVDYALLL-LI--PLPTLFYIATTRISEP 326
XP_002130041 270 TYTfLTWKNLLfLLctPFPMIFFLLTERFSDP 301
2_pfamImport 263 SYPaLTFQNLLfLLctPFPLVFFLLTEHFSDP 294
XP_003388492 282 SDVkTRSYFLP-LV--LLPPLIHPVLNHFAAP 310
XP_002636815 507 DIQ-YRWSLLC-LV--PVPLVFYLITIPFSNP 534
XP_015788929 278 KNPvVTTSLLL-LV--PFPSVFYILTSKFSDP 306
XP_002610598 285 KEPlIHGPLLS-LT--PTPAIFYLLTVKFTEP 313
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