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    PTAR1 protein prenyltransferase alpha subunit repeat containing 1 [ Homo sapiens (human) ]

    Gene ID: 375743, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PTAR1provided by HGNC
    Official Full Name
    protein prenyltransferase alpha subunit repeat containing 1provided by HGNC
    Primary source
    HGNC:HGNC:30449
    See related
    Ensembl:ENSG00000188647 AllianceGenome:HGNC:30449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein prenyltransferase activity. Predicted to be involved in protein prenylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 7.3), bone marrow (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q21.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (69709525..69760011, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (81876142..81926623, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72324441..72374927, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902177 Neighboring gene Sharpr-MPRA regulatory region 1664 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:72081305-72082504 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene uncharacterized LOC124902178 Neighboring gene 9q21.12 proximal LINE-mediated recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:72120629-72121248 Neighboring gene 9q21.12 distal LINE-mediated recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19936 Neighboring gene uncharacterized LOC105376076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:72375949-72376804 Neighboring gene Sharpr-MPRA regulatory region 8756 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:72377659-72378514 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:72378515-72379369 Neighboring gene Sharpr-MPRA regulatory region 12610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19937 Neighboring gene CFAP95 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase. Kuchay S, et al. Nat Struct Mol Biol, 2019 Jul. PMID 31209342, Free PMC Article
    2. A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus. Shirakawa R, et al. EMBO J, 2020 Apr 15. PMID 32128853, Free PMC Article
    3. Gene essentiality and synthetic lethality in haploid human cells. Blomen VA, et al. Science, 2015 Nov 27. PMID 26472760
    4. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. Adhikari H, et al. Nat Commun, 2018 Sep 7. PMID 30194290, Free PMC Article
    5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ45604

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein prenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein prenyltransferase alpha subunit repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099666.2 → NP_001093136.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001093136.1

      Status: VALIDATED

      Source sequence(s)
      AI937926, AL162412, BC053622, BM785278
      Consensus CDS
      CCDS47978.1
      UniProtKB/Swiss-Prot
      Q5T7V5, Q5T7V6, Q7Z6K3
      Related
      ENSP00000344299.4, ENST00000340434.5
      Conserved Domains (1) summary
      pfam01239
      Location:180 → 207
      PPTA; Protein prenyltransferase alpha subunit repeat

    2. NM_001366935.1 → NP_001353864.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Consensus CDS
      CCDS94417.1
      UniProtKB/TrEMBL
      X6R9N0
      Related
      ENSP00000366405.5, ENST00000377200.9
      Conserved Domains (1) summary
      pfam01239
      Location:101 → 128
      PPTA; Protein prenyltransferase alpha subunit repeat

    3. NM_001366936.1 → NP_001353865.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Conserved Domains (1) summary
      cl27590
      Location:82 → 208
      PPTA; Protein prenyltransferase alpha subunit repeat

    4. NM_001366937.1 → NP_001353866.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Conserved Domains (1) summary
      cl27590
      Location:88 → 208
      PPTA; Protein prenyltransferase alpha subunit repeat

    5. NM_001366938.1 → NP_001353867.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Conserved Domains (1) summary
      pfam01239
      Location:101 → 128
      PPTA; Protein prenyltransferase alpha subunit repeat

    6. NM_001366939.1 → NP_001353868.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Conserved Domains (1) summary
      cl27590
      Location:88 → 208
      PPTA; Protein prenyltransferase alpha subunit repeat

    7. NM_001366940.1 → NP_001353869.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL162412
      Conserved Domains (1) summary
      PLN02789
      Location:88 → 208
      PLN02789; farnesyltranstransferase

    RNA

    1. NR_159515.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL162412

    2. NR_159516.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL162412

    3. NR_159517.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL162412

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      69709525..69760011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423355.1 → XP_047279311.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X5

    2. XM_047423353.1 → XP_047279309.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X2

    3. XM_011518639.2 → XP_011516941.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam01239
      Location:142 → 169
      PPTA; Protein prenyltransferase alpha subunit repeat

    4. XM_005251980.6 → XP_005252037.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X4

      Conserved Domains (1) summary
      PLN02789
      Location:88 → 208
      PLN02789; farnesyltranstransferase

    5. XM_047423354.1 → XP_047279310.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      81876142..81926623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362930.1 → XP_054218905.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X5

    2. XM_054362927.1 → XP_054218902.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X2

    3. XM_054362926.1 → XP_054218901.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X1

    4. XM_054362929.1 → XP_054218904.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X4

    5. XM_054362928.1 → XP_054218903.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z6K3.2 GenPept UniProtKB/Swiss-Prot:Q7Z6K3

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