4LNB,4LNB,4LNB,3PZ1


Conserved Protein Domain Family
PPTA
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pfam01239: PPTA (this model, PSSM-Id:279565 is obsolete and has been replaced by 460128)
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Protein prenyltransferase alpha subunit repeat
Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognize a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognizes a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family.
Links
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Statistics
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PSSM-Id: 279565
Aligned: 841 rows
Threshold Bit Score: 26.9656
Created: 20-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4LNB_A        73 ALRLTGDIISMNPAHYTVWIYRAKILFA 100 Aspergillus fumigatus Af293
XP_004932633 206 EVCYTLEKINFVKNNESAWNYLRGLLIH 233 domestic silkworm
XP_011448605 208 EVEYTQEFIKKAPNNESAWNYLKGVLMD 235 Pacific oyster
XP_001641349 207 EVKFVLDLIEKVPNNESAWNYLKGVLSK 234 starlet sea anemone
XP_003226079 231 EVQYTLEMIRMVPHNESAWNYLKGILQD 258 green anole
NP_001116893 252 EVQYALEMIKVAPHNESAWNYLRGILQE 279 western clawed frog
XP_006629920 237 EVQYCLQSIRKAPQNESAWNYLKGILQd 264 spotted gar
XP_003970182 234 EIEYCLTQIKKAHHNESAWNYLKGMLQN 261 torafugu
XP_006957359 203 EIDYVLSLISKAPSNMSSWNYLRGILKv 230 Wallemia sebi CBS 633.66
EFO65438     201 ELSFVDSALSKTPANQAIWDYLRGLYDW 228 Giardia lamblia P15
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