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Gnl2 guanine nucleotide binding protein nucleolar 2 [ Mus musculus (house mouse) ]

Gene ID: 230737, updated on 5-May-2024

Summary

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Official Symbol
Gnl2provided by MGI
Official Full Name
guanine nucleotide binding protein nucleolar 2provided by MGI
Primary source
MGI:MGI:2385207
See related
Ensembl:ENSMUSG00000028869 AllianceGenome:MGI:2385207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngp-1; HUMAUANTIG
Summary
Predicted to enable GTP binding activity. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in peripheral nervous system ganglion; renal cortex; thymus primordium; and vibrissa. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.5), CNS E18 (RPKM 17.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.97 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124920866..124949175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125029989..125055382)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12930 Neighboring gene R-spondin 1 Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene dynein, axonemal, light intermediate polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  2. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7863

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleolar GTP-binding protein 2
Names
guanine nucleotide binding protein-like 2 (nucleolar)
testicular antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145552.2 → NP_663527.2  nucleolar GTP-binding protein 2

    See identical proteins and their annotated locations for NP_663527.2

    Status: VALIDATED

    Source sequence(s)
    AK037796, AK077532, AV236719, BY140435
    Consensus CDS
    CCDS18634.1
    UniProtKB/Swiss-Prot
    B1ASC3, Q8BIF8, Q99LH1
    UniProtKB/TrEMBL
    Q3UJL0
    Related
    ENSMUSP00000030684.8, ENSMUST00000030684.8
    Conserved Domains (2) summary
    cd01858
    Location:209 → 365
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    pfam08153
    Location:43 → 174
    NGP1NT; NGP1NT (NUC091) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124920866..124949175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164045.1 → XP_036019938.1  nucleolar GTP-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B1ASC3, Q8BIF8, Q99LH1
    UniProtKB/TrEMBL
    Q3UJL0
    Conserved Domains (2) summary
    cd01858
    Location:209 → 365
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    pfam08153
    Location:43 → 174
    NGP1NT; NGP1NT (NUC091) domain

  2. XM_006503029.4 → XP_006503092.1  nucleolar GTP-binding protein 2 isoform X2

    Conserved Domains (2) summary
    cd01858
    Location:50 → 206
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:157 → 262
    Der; Predicted GTPases [General function prediction only]

  3. XM_030253448.2 → XP_030109308.1  nucleolar GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01858
    Location:2 → 154
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:105 → 210
    Der; Predicted GTPases [General function prediction only]

  4. XM_017320153.2 → XP_017175642.1  nucleolar GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01858
    Location:2 → 154
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:105 → 210
    Der; Predicted GTPases [General function prediction only]

  5. XM_030253450.2 → XP_030109310.1  nucleolar GTP-binding protein 2 isoform X4

    Conserved Domains (2) summary
    cd01858
    Location:1 → 136
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:87 → 192
    Der; Predicted GTPases [General function prediction only]

  6. XM_030253449.2 → XP_030109309.1  nucleolar GTP-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd01858
    Location:2 → 154
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:105 → 210
    Der; Predicted GTPases [General function prediction only]

  7. XM_011240502.3 → XP_011238804.1  nucleolar GTP-binding protein 2 isoform X4

    Conserved Domains (2) summary
    cd01858
    Location:1 → 136
    NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
    COG1160
    Location:87 → 192
    Der; Predicted GTPases [General function prediction only]

  8. XM_030253451.2 → XP_030109311.1  nucleolar GTP-binding protein 2 isoform X5

    Conserved Domains (1) summary
    COG1161
    Location:1 → 113
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LH1.2 GenPept UniProtKB/Swiss-Prot:Q99LH1

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