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Nuclear Cataract Grade 2

MedGen UID:
1622334
•Concept ID:
C4525724
•
Disease or Syndrome

Definition

A stage of nuclear sclerotic cataract marked by moderate yellowing and sclerosis of the lens nucleus. (Modified LOCS II) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNuclear Cataract Grade 2

Professional guidelines

PubMed

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Management of Severely Subluxated Cataracts Using Femtosecond Laser-Assisted Cataract Surgery.
Chee SP, Wong MH, Jap A
Am J Ophthalmol 2017 Jan;173:7-15. Epub 2016 Sep 23 doi: 10.1016/j.ajo.2016.09.021. PMID: 27670621

Recent clinical studies

Etiology

Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.
Trott M, Smith L, Veronese N, Pizzol D, Barnett Y, Gorely T, Pardhan S
Eye (Lond) 2022 Feb;36(2):369-378. Epub 2021 Jul 16 doi: 10.1038/s41433-021-01684-x. PMID: 34272511Free PMC Article
Wholegrain and legume consumption and the 5-year incidence of age-related cataract in the Blue Mountains Eye Study.
Tan AG, Flood VM, Kifley A, Russell J, Cumming RG, Mitchell P, Wang JJ
Br J Nutr 2020 Aug 14;124(3):306-315. Epub 2020 Mar 19 doi: 10.1017/S000711452000104X. PMID: 32189601
Cortical Cataract and Refractive Error.
Michael R, Pareja-Aricò L, Rauscher FG, Barraquer RI
Ophthalmic Res 2019;62(3):157-165. Epub 2019 Mar 28 doi: 10.1159/000496865. PMID: 30921809
Exome Array Analysis of Nuclear Lens Opacity.
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

Diagnosis

A case report of iridoschisis and cataract: a challenging diagnosis.
Katipoğlu Z, Turan M
Int Ophthalmol 2024 Feb 7;44(1):26. doi: 10.1007/s10792-024-03001-3. PMID: 38326697
AI-based diagnosis of nuclear cataract from slit-lamp videos.
Shimizu E, Tanji M, Nakayama S, Ishikawa T, Agata N, Yokoiwa R, Nishimura H, Khemlani RJ, Sato S, Hanyuda A, Sato Y
Sci Rep 2023 Dec 12;13(1):22046. doi: 10.1038/s41598-023-49563-7. PMID: 38086904Free PMC Article
Cataract quantification using swept-source optical coherence tomography.
Brás JEG, Sickenberger W, Hirnschall N, Findl O
J Cataract Refract Surg 2018 Dec;44(12):1478-1481. Epub 2018 Nov 2 doi: 10.1016/j.jcrs.2018.08.009. PMID: 30392762
Exome Array Analysis of Nuclear Lens Opacity.
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907

Therapy

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Comparative study of FLACS vs conventional phacoemulsification for complex cataracts in vitrectomized eyes.
Cai L, Ma D, Xu X, Han X, Qiu X, Lu Y, Yang J
J Cataract Refract Surg 2022 Dec 1;48(12):1381-1387. doi: 10.1097/j.jcrs.0000000000000998. PMID: 36449671
Ultrasound energy consumption and macular changes with manual and femtolaser-assisted high-fluidics cataract surgery: a prospective randomized comparison.
Menapace R, Schartmüller D, Röggla V, Reiter GS, Leydolt C, Schwarzenbacher L
Acta Ophthalmol 2022 Mar;100(2):e414-e422. Epub 2021 Sep 20 doi: 10.1111/aos.14983. PMID: 34543523Free PMC Article
Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.
Trott M, Smith L, Veronese N, Pizzol D, Barnett Y, Gorely T, Pardhan S
Eye (Lond) 2022 Feb;36(2):369-378. Epub 2021 Jul 16 doi: 10.1038/s41433-021-01684-x. PMID: 34272511Free PMC Article
Wholegrain and legume consumption and the 5-year incidence of age-related cataract in the Blue Mountains Eye Study.
Tan AG, Flood VM, Kifley A, Russell J, Cumming RG, Mitchell P, Wang JJ
Br J Nutr 2020 Aug 14;124(3):306-315. Epub 2020 Mar 19 doi: 10.1017/S000711452000104X. PMID: 32189601

Prognosis

Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.
Trott M, Smith L, Veronese N, Pizzol D, Barnett Y, Gorely T, Pardhan S
Eye (Lond) 2022 Feb;36(2):369-378. Epub 2021 Jul 16 doi: 10.1038/s41433-021-01684-x. PMID: 34272511Free PMC Article
Wholegrain and legume consumption and the 5-year incidence of age-related cataract in the Blue Mountains Eye Study.
Tan AG, Flood VM, Kifley A, Russell J, Cumming RG, Mitchell P, Wang JJ
Br J Nutr 2020 Aug 14;124(3):306-315. Epub 2020 Mar 19 doi: 10.1017/S000711452000104X. PMID: 32189601
Exome Array Analysis of Nuclear Lens Opacity.
Loomis SJ, Klein AP, Lee KE, Chen F, Bomotti S, Truitt B, Iyengar SK, Klein R, Klein BEK, Duggal P
Ophthalmic Epidemiol 2018 Jun;25(3):215-219. Epub 2017 Nov 28 doi: 10.1080/09286586.2017.1406122. PMID: 29182452Free PMC Article
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Corneal endothelial changes following cataract surgery in hard nuclear cataract: Randomized trial comparing phacoemulsification to manual small-incision cataract surgery.
Singh R, Sharma AK, Katiyar V, Kumar G, Gupta SK
Indian J Ophthalmol 2022 Nov;70(11):3904-3909. doi: 10.4103/ijo.IJO_1304_22. PMID: 36308124Free PMC Article
Evaluation of efficacy of intracameral lidocaine and tropicamide injection in manual small-incision cataract surgery: A prospective clinical study.
Bhat KT, Wadgaonkar SP, Undre AA, Heda AS
Indian J Ophthalmol 2022 Nov;70(11):3849-3852. doi: 10.4103/ijo.IJO_2050_22. PMID: 36308110Free PMC Article
Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.
Trott M, Smith L, Veronese N, Pizzol D, Barnett Y, Gorely T, Pardhan S
Eye (Lond) 2022 Feb;36(2):369-378. Epub 2021 Jul 16 doi: 10.1038/s41433-021-01684-x. PMID: 34272511Free PMC Article
Objective assessment of nuclear cataract: comparison of double-pass and Scheimpflug systems.
Lim SA, Hwang J, Hwang KY, Chung SH
J Cataract Refract Surg 2014 May;40(5):716-21. doi: 10.1016/j.jcrs.2013.10.032. PMID: 24767907
The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group.
Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY
Arch Ophthalmol 1993 Jun;111(6):831-6. doi: 10.1001/archopht.1993.01090060119035. PMID: 8512486

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