NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE6967 Query DataSets for GSE6967
Status Public on Apr 27, 2007
Title Spermatozoal RNA Profiles (Human-6 BeadChip)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Normal human spermatogenesis concludes with the formation of large numbers of morphologically well developed spermatozoa. While transcriptionally quiescent these cells carry an RNA payload that reflects the final spermiogenic phase of transcription. We report here the spermatozoal transcript profiles characteristic of normally fertile individuals and infertile males suffering from a consistent and severe teratozoospermia in which under 4% of spermatozoa are morphologically normal. RNA was extracted from the purified sperm cells of ejaculate and hybridized to Illumina WG6 Microarrays.
Keywords: disease state analysis
 
Overall design Spermatozoal RNAs were prepared from the semen samples of 13 individuals. An asymmetric dual block design was adopted with biological replicates in both blocks. 5 semen samples were assessed from normally fertile males who had fathered at least one child. 8 semen samples were assessed from infertile individuals with a severe and consistent heterogeneous teratozoospermia who showed no other abnormal semen parameters.
Web link http://compbio.med.wayne.edu
 
Contributor(s) Platts AE, Dix DJ, Chemes HE, Thompson KE, Goodrich R, Rockett JC, Rawe VY, Quintana S, Diamond MP, Strader LF, Krawetz SA
Citation(s) 17327269
Submission date Feb 06, 2007
Last update date Mar 17, 2012
Contact name Stephen A Krawetz
E-mail(s) steve@compbio.med.wayne.edu
Organization name Wayne State University
Street address 275 East Hancock, CS Mott Center
City Detroit
State/province MI
ZIP/Postal code 48207
Country USA
 
Platforms (1)
GPL2507 Sentrix Human-6 Expression BeadChip
Samples (13)
GSM160620 Teratozoospermic individual: Sample T2
GSM160621 Teratozoospermic individual: Sample T1
GSM160622 Teratozoospermic individual: Sample T6
This SubSeries is part of SuperSeries:
GSE6969 Spermatozoal RNA Profiles from Normally Fertile and Heterogeneously Teratozoospermic Subjects
Relations
BioProject PRJNA104135

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6967_RAW.tar 11.4 Mb (http)(custom) TAR (of TXT)

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap