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| Status |
Public on Jan 29, 2011 |
| Title |
Expression data for human epithelium from subjects with atopic dermatitis, psoriasis and nonatopic controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis.
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| Overall design |
Gene expression profiling was performed on total RNA from nonlesional epidermal samples from 5 subjects with atopic dermatitis, 4 subjects with
psoriasis, and 5 nonatopic controls using the Illumina Sentrix HumanRef-8 Expression BeadChip. There were duplicate (technical replicate) arrays run for 2 of the nonatopic control samples (the normalized transformed expression values of replicate pairs were averaged before performing data analysis, also, for each probe, the combined value for replicate pairs of Detection Pvalues was taken to be their minimum - so a Present call for one of the replicate pair of expression values results in a Present call for the combined (average) expression value).
Details of the design and the results found are given in the paper associated with this GEO Series.
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| Contributor(s) |
De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA |
| Citation(s) |
21163515 |
| Submission date |
Jan 28, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
Alan E. Berger |
| E-mail(s) |
alanberger@alum.mit.edu
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| Phone |
301-938-3565
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| Organization name |
Johns Hopkins University
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| Department |
School of Medicine
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| Lab |
Division of Allergy and Clinical Immunology
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| Street address |
5501 Hopkins Bayview Circle Room 3B.74C
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21224 |
| Country |
USA |
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| Platforms (1) |
| GPL2700 |
Sentrix HumanRef-8 Expression BeadChip |
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| Samples (16)
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| GSM663510 |
Nonlesional Epithelium Atopic Dermatitis rep1 |
| GSM663511 |
Nonlesional Epithelium Atopic Dermatitis rep2 |
| GSM663512 |
Nonlesional Epithelium Atopic Dermatitis rep3 |
| GSM663513 |
Nonlesional Epithelium Atopic Dermatitis rep4 |
| GSM663514 |
Nonlesional Epithelium Atopic Dermatitis rep5 |
| GSM663515 |
Nonlesional Epithelium Psoriasis rep1 |
| GSM663516 |
Nonlesional Epithelium Psoriasis rep2 |
| GSM663517 |
Nonlesional Epithelium Psoriasis rep3 |
| GSM663518 |
Nonlesional Epithelium Psoriasis rep4 |
| GSM663519 |
Nonlesional Epithelium Nonatopic Control rep1 |
| GSM663520 |
Nonlesional Epithelium Nonatopic Control rep2a |
| GSM663521 |
Nonlesional Epithelium Nonatopic Control rep2b |
| GSM663522 |
Nonlesional Epithelium Nonatopic Control rep3 |
| GSM663523 |
Nonlesional Epithelium Nonatopic Control rep4a |
| GSM663524 |
Nonlesional Epithelium Nonatopic Control rep4b |
| GSM663525 |
Nonlesional Epithelium Nonatopic Control rep5 |
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| Relations |
| BioProject |
PRJNA136959 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE26952_non-normalized.txt.gz |
1.5 Mb |
(ftp)(http) |
TXT |
| GSE26952_normalized-Z-transformed.txt.gz |
1.7 Mb |
(ftp)(http) |
TXT |
| GSE26952_scaled_log2_transformed_data_replicate_pairs_combined.txt.gz |
1.5 Mb |
(ftp)(http) |
TXT |
| GSE26952_ztransformed_data_replicate_pairs_combined.txt.gz |
1.5 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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