|
| Status |
Public on Mar 11, 2004 |
| Title |
MeHg-induced encephalopathy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
In this dose series pregnant CD-1 (outbred) dams were exposed to methylmercury (MeHg) as monomethylmercuric chloride injected intraperitoneally on 9 d.p.c. Test doses were 10.0 mg/kg and below. This regimen induces symptoms of Fetal Minimata Disease (FMD) in term fetuses. Risks with respect to FMD for the various test doses were 10.0 mg/kg (40% risk), 5.0 mg/kg (20% risk), 2.5 mg/kg (NOAEL), and 1.25 mg/kg (subNOAEL). All measurements were on RNA from the embryonic forebrain (prosencephalon and surrounding tissue) at 3.0h post-treatment.
Keywords = dose series
Keywords = mercury
Keywords = embryo
Keywords = Fetal Minamata Disease
Keywords: dose response
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| |
|
| Overall design |
Test doses were 10.0 mg/kg (40% risk), 5.0 mg/kg (20% risk), 2.5 mg/kg (NOAEL), and 1.25 mg/kg (subNOAEL).
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| |
|
| Contributor(s) |
Knudsen TB, Nemeth KR, Singh AV, Charlap JH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 26, 2004 |
| Last update date |
Mar 02, 2012 |
| Contact name |
Thomas B Knudsen |
| E-mail(s) |
singh.amarv@epamail.epa.gov
|
| Phone |
502-852-4128
|
| Fax |
502-852-4702
|
| URL |
http://systemsanalysis.louisville.edu/
|
| Organization name |
University of Louisville
|
| Department |
Birth Defects Center
|
| Lab |
Systems Analysis Laboratory
|
| Street address |
501 S Preston St
|
| City |
Louisville |
| State/province |
KY |
| ZIP/Postal code |
40202 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL560 |
Developmental Toxicity of the Mouse Embryo (DTME) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA87171 |
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