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    FASTK Fas activated serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 10922, updated on 7-Apr-2024

    Summary

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    Official Symbol
    FASTKprovided by HGNC
    Official Full Name
    Fas activated serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:24676
    See related
    Ensembl:ENSG00000164896 MIM:606965; AllianceGenome:HGNC:24676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAST
    Summary
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 16.4), prostate (RPKM 16.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q36.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151076624..151080809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152249742..152253931, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150773711..150777896, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150750636-150751136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150754255-150754788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150757470-150758377 Neighboring gene uncharacterized LOC128092247 Neighboring gene cyclin dependent kinase 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150762350-150763332 Neighboring gene solute carrier family 4 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150766873-150767373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150772333-150773310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150773311-150774286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150774287-150775262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150776239-150777215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150777216-150778191 Neighboring gene Sharpr-MPRA regulatory region 12172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26851 Neighboring gene uncharacterized LOC124901778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150786615-150787125 Neighboring gene transmembrane and ubiquitin like domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150787126-150787635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150787761-150788266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150788267-150788772 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150800613-150801520

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Systematic Analysis of FASTK Gene Family Alterations in Cancer. Magraner-Pardo L, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768773, Free PMC Article
    2. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Li W, et al. Mol Cell Biol, 2004 Dec. PMID 15572676, Free PMC Article
    3. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Jourdain AA, et al. Cell Rep, 2015 Feb 24. PMID 25704814
    4. miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK. Zhi F, et al. PLoS One, 2013. PMID 24013584, Free PMC Article
    5. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. Simarro M, et al. J Immunol, 2010 May 1. PMID 20363972, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
      Title: Accuracy of FAST in detecting intraabdominal bleeding in major trauma with pelvic and/or acetabular fractures: a retrospective cohort study.
    2. Systematic Analysis of FASTK Gene Family Alterations in Cancer.
      Title: Systematic Analysis of FASTK Gene Family Alterations in Cancer.
    3. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis.
      Title: A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
    4. MIR-106a-5p functions as a tumor suppressor during the development of astrocytomas by targeting FASTK.
      Title: miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK.
    5. FAST expression on lung cells of hematopoietic origin is crucial in mediating lipopolysaccharide-induced neutrophil migration to the lung in transgenic FAST-deficient mice compared with wild type controls.
      Title: Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    7. Nuclear FAST can regulate the splicing of FGFR2 transcripts.
      Title: Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing.
    8. FAST K synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
      Title: Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing.
    9. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1 regulated changes in protein expression.
      Title: FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Fas-activated serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fas-activated serine/threonine kinase
    Names
    FAST kinase
    NP_001245390.1
    NP_006703.1
    NP_148936.2
    XP_005249989.1
    XP_011514063.1
    XP_011514064.1
    XP_011514065.1
    XP_016867194.1
    XP_047275784.1
    XP_047275786.1
    XP_047275787.1
    XP_054213124.1
    XP_054213125.1
    XP_054213126.1
    XP_054213127.1
    XP_054213128.1
    XP_054213129.1
    XP_054213130.1
    XP_054213131.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258461.2 → NP_001245390.1  fas-activated serine/threonine kinase isoform 5

      See identical proteins and their annotated locations for NP_001245390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AB209783, AC010973, DA253544
      Consensus CDS
      CCDS59088.1
      UniProtKB/TrEMBL
      Q53FZ9
      Related
      ENSP00000418516.1, ENST00000482571.2
      Conserved Domains (3) summary
      smart00952
      Location:457 → 509
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:250 → 316
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:328 → 417
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_006712.5 → NP_006703.1  fas-activated serine/threonine kinase isoform 1

      See identical proteins and their annotated locations for NP_006703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC011770, BU682096, DA253544
      Consensus CDS
      CCDS5918.1
      UniProtKB/Swiss-Prot
      A8K867, F8VTW9, Q14296, Q59EM8, Q8IVA0
      UniProtKB/TrEMBL
      A0A090N8Z7, Q53FZ9
      Related
      ENSP00000297532.6, ENST00000297532.11
      Conserved Domains (3) summary
      smart00952
      Location:484 → 536
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:278 → 343
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:358 → 443
      FAST_2; FAST kinase-like protein, subdomain 2

    3. NM_033015.4 → NP_148936.2  fas-activated serine/threonine kinase isoform 4

      See identical proteins and their annotated locations for NP_148936.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC010973, BC039026
      Consensus CDS
      CCDS5919.1
      UniProtKB/TrEMBL
      A0A090N8I0
      Related
      ENSP00000324817.6, ENST00000353841.6
      Conserved Domains (3) summary
      smart00952
      Location:343 → 395
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:137 → 202
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:217 → 302
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      151076624..151080809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515763.2 → XP_011514065.1  fas-activated serine/threonine kinase isoform X6

      See identical proteins and their annotated locations for XP_011514065.1

      Conserved Domains (3) summary
      smart00952
      Location:316 → 368
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:110 → 175
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:190 → 275
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_047419831.1 → XP_047275787.1  fas-activated serine/threonine kinase isoform X8

    3. XM_017011705.3 → XP_016867194.1  fas-activated serine/threonine kinase isoform X7

    4. XM_047419828.1 → XP_047275784.1  fas-activated serine/threonine kinase isoform X3

    5. XM_011515762.4 → XP_011514064.1  fas-activated serine/threonine kinase isoform X4

      UniProtKB/TrEMBL
      Q9BWD7
      Conserved Domains (2) summary
      pfam06743
      Location:278 → 343
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:358 → 428
      FAST_2; FAST kinase-like protein, subdomain 2

    6. XM_011515761.4 → XP_011514063.1  fas-activated serine/threonine kinase isoform X2

      See identical proteins and their annotated locations for XP_011514063.1

      UniProtKB/TrEMBL
      Q9BWD7
      Conserved Domains (2) summary
      pfam06743
      Location:278 → 343
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:358 → 443
      FAST_2; FAST kinase-like protein, subdomain 2

    7. XM_047419830.1 → XP_047275786.1  fas-activated serine/threonine kinase isoform X5

    8. XM_005249932.2 → XP_005249989.1  fas-activated serine/threonine kinase isoform X1

      See identical proteins and their annotated locations for XP_005249989.1

      UniProtKB/TrEMBL
      Q53FZ9
      Conserved Domains (3) summary
      smart00952
      Location:450 → 502
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:244 → 309
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:324 → 409
      FAST_2; FAST kinase-like protein, subdomain 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      152249742..152253931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357153.1 → XP_054213128.1  fas-activated serine/threonine kinase isoform X5

    2. XM_054357154.1 → XP_054213129.1  fas-activated serine/threonine kinase isoform X6

    3. XM_054357156.1 → XP_054213131.1  fas-activated serine/threonine kinase isoform X8

    4. XM_054357155.1 → XP_054213130.1  fas-activated serine/threonine kinase isoform X7

    5. XM_054357151.1 → XP_054213126.1  fas-activated serine/threonine kinase isoform X3

    6. XM_054357152.1 → XP_054213127.1  fas-activated serine/threonine kinase isoform X4

    7. XM_054357150.1 → XP_054213125.1  fas-activated serine/threonine kinase isoform X2

    8. XM_054357149.1 → XP_054213124.1  fas-activated serine/threonine kinase isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14296.1 GenPept UniProtKB/Swiss-Prot:Q14296

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