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    FUT3 fucosyltransferase 3 (Lewis blood group) [ Homo sapiens (human) ]

    Gene ID: 2525, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FUT3provided by HGNC
    Official Full Name
    fucosyltransferase 3 (Lewis blood group)provided by HGNC
    Primary source
    HGNC:HGNC:4014
    See related
    Ensembl:ENSG00000171124 MIM:111100; AllianceGenome:HGNC:4014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LE; Les; FT3B; CD174; FucT-III
    Summary
    The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020]
    Annotation information
    Annotation category: suggests misassembly
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
    Expression
    Biased expression in colon (RPKM 29.8), esophagus (RPKM 25.0) and 7 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5842888..5857122, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5830330..5844569, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5842899..5857133, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene fucosyltransferase 6 Neighboring gene uncharacterized LOC101928844 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5855126-5855513 Neighboring gene Sharpr-MPRA regulatory region 2774 Neighboring gene Sharpr-MPRA regulatory region 10376 Neighboring gene fucosyltransferase 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5892267-5893073 Neighboring gene MPRA-validated peak3300 silencer Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene Sharpr-MPRA regulatory region 9916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Correlations of FUT3 gene polymorphisms with colon polyps. Hu X, et al. Cell Cycle, 2022 Jan. PMID 34936845, Free PMC Article
    2. Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3. Soejima M, et al. Vox Sang, 2022 Feb. PMID 34156094
    3. Associations between fucosyltransferase 3 gene polymorphisms and ankylosing spondylitis: A case-control study of an east Chinese population. Jiang G, et al. PLoS One, 2020. PMID 32764781, Free PMC Article
    4. The landscape of host genetic factors involved in immune response to common viral infections. Kachuri L, et al. medRxiv, 2020 Sep 5. PMID 32511533, Free PMC Article
    5. More on 'Association between ABO blood groups and risk of SARS-CoV-2 pneumonia'. O'Sullivan JM, et al. Br J Haematol, 2020 Jul. PMID 32420611, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-kappaB pathway.
      Title: FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway.
    2. Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
      Title: Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype.
    3. Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
      Title: Maternal and child FUT2 and FUT3 status demonstrate relationship with gut health, body composition and growth of children in Bangladesh.
    4. Correlations of FUT3 gene polymorphisms with colon polyps.
      Title: Correlations of FUT3 gene polymorphisms with colon polyps.
    5. Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
      Title: Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
    6. Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
      Title: Estimation of genetic variation in the Secretor and Lewis genes in Iranian hospitalized children.
    7. Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
      Title: Norovirus infection and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil.
    8. FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
      Title: FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil.
    9. High FUT3 expression is a marker of lower overall survival of breast cancer patients.
      Title: High FUT3 expression is a marker of lower overall survival of breast cancer patients.
    10. Systematic sequence analysis of the FUT3 gene identifies 11 novel alleles in the Sindhi and Punjabi populations from Pakistan.
      Title: Systematic sequence analysis of the FUT3 gene identifies 11 novel alleles in the Sindhi and Punjabi populations from Pakistan.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Blood group, lewis system
    MedGen: C0023595 OMIM: 618983 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
    EBI GWAS Catalog
    Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131739

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell recognition IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macromolecule glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in oligosaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
    Names
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
    Lewis FT
    alpha-(1,3/1,4)-fucosyltransferase
    alpha-3-fucosyltransferase FUT3
    blood group Lewis alpha-4-fucosyltransferase
    fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
    fucosyltransferase III
    galactoside 3(4)-L-fucosyltransferase
    NP_000140.1
    NP_001091108.3
    NP_001091109.3
    NP_001091110.3
    NP_001361669.1
    NP_001369673.1
    NP_001369674.1
    NP_001369675.1
    NP_001369676.1
    NP_001369677.1
    NP_001369678.1
    NP_001369679.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007482.2 RefSeqGene

      Range
      10674..19235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_800

    mRNA and Protein(s)

    1. NM_000149.4 → NP_000140.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      See identical proteins and their annotated locations for NP_000140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as minor I, represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Related
      ENSP00000305603.5, ENST00000303225.12
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. NM_001097639.3 → NP_001091108.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as major II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Related
      ENSP00000465804.1, ENST00000589620.6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. NM_001097640.3 → NP_001091109.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as major I, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Related
      ENSP00000468123.1, ENST00000589918.5
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    4. NM_001097641.3 → NP_001091110.3  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as minor II, differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Related
      ENSP00000416443.1, ENST00000458379.7
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    5. NM_001374740.1 → NP_001361669.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    6. NM_001382744.1 → NP_001369673.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    7. NM_001382745.1 → NP_001369674.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    8. NM_001382746.1 → NP_001369675.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    9. NM_001382747.1 → NP_001369676.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      AC024592, U27328
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    10. NM_001382748.2 → NP_001369677.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      NTIA01000094
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    11. NM_001382749.2 → NP_001369678.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      NTIA01000094
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    12. NM_001382750.2 → NP_001369679.1  3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

      Status: REVIEWED

      Source sequence(s)
      NTIA01000094
      Consensus CDS
      CCDS12153.1
      UniProtKB/TrEMBL
      A0A9E8S311, A8K737, B3W6H0, B5B9M4, Q9P1W6
      Conserved Domains (2) summary
      pfam00852
      Location:189 → 357
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:60 → 170
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      5842888..5857122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791810.1 Reference GRCh38.p14 PATCHES

      Range
      16467..30706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      5830330..5844569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21217.2 GenPept UniProtKB/Swiss-Prot:P21217

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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