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Conserved domains on  [gi|1843978512|ref|NP_001369674|]
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3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 [Homo sapiens]

Protein Classification

glycosyltransferase family 10 fucosyltransferase( domain architecture ID 11246723)

glycosyltransferase family 10 fucosyltransferase transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage

CAZY:  GT10
EC:  2.4.1.-
Gene Ontology:  GO:0006486|GO:0008417
PubMed:  9451017|9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 186-359 2.24e-99

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


:

Pssm-ID: 459962  Cd Length: 176  Bit Score: 291.38  E-value: 2.24e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 186 LSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGR--SHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWrN 263
Cdd:pfam00852   1 LPKKTKLVAWVVSNCNTSSARVKYYNELQKHIEVDVYGRcgNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLW-N 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 264 ALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWK 343
Cdd:pfam00852  80 ALLRGAVPVVLGPPRANYERFAPPDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRKHYRVIPLSSWEPFCDLCQK 159

                         170
                  ....*....|....*..
gi 1843978512 344 LQQESR-YQTVRSIAAW 359
Cdd:pfam00852 160 LHRDSRrYKTYPDLAKW 176
Glyco_tran_10_N pfam17039
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 60-170 1.56e-48

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


:

Pssm-ID: 465336  Cd Length: 109  Bit Score: 159.01  E-value: 1.56e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512  60 RPTLLILLWTWPFHIPVALSRCSEMVpGTADCHITADRKVYPQADTVIVHHWDImSNPKSRLPPSPRPQGQRWIWFNLEP 139
Cdd:pfam17039   1 KNLKLILLWTWPFGDSFDLLGCSDLF-GITGCRLTYDRSLYPEADAVVFHHRDI-SLDLKDLPYSPRPPGQRWVWFNLES 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1843978512 140 PPNCQHLEALDRYFNLTMSYRSDSDIFTPYG 170
Cdd:pfam17039  79 PTNTPRLPGLDNFFNWTMTYRRDSDIFTPYG 109
 
Name Accession Description Interval E-value
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 186-359 2.24e-99

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 291.38  E-value: 2.24e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 186 LSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGR--SHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWrN 263
Cdd:pfam00852   1 LPKKTKLVAWVVSNCNTSSARVKYYNELQKHIEVDVYGRcgNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLW-N 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 264 ALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWK 343
Cdd:pfam00852  80 ALLRGAVPVVLGPPRANYERFAPPDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRKHYRVIPLSSWEPFCDLCQK 159

                         170
                  ....*....|....*..
gi 1843978512 344 LQQESR-YQTVRSIAAW 359
Cdd:pfam00852 160 LHRDSRrYKTYPDLAKW 176
Glyco_tran_10_N pfam17039
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 60-170 1.56e-48

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


Pssm-ID: 465336  Cd Length: 109  Bit Score: 159.01  E-value: 1.56e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512  60 RPTLLILLWTWPFHIPVALSRCSEMVpGTADCHITADRKVYPQADTVIVHHWDImSNPKSRLPPSPRPQGQRWIWFNLEP 139
Cdd:pfam17039   1 KNLKLILLWTWPFGDSFDLLGCSDLF-GITGCRLTYDRSLYPEADAVVFHHRDI-SLDLKDLPYSPRPPGQRWVWFNLES 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1843978512 140 PPNCQHLEALDRYFNLTMSYRSDSDIFTPYG 170
Cdd:pfam17039  79 PTNTPRLPGLDNFFNWTMTYRRDSDIFTPYG 109
 
Name Accession Description Interval E-value
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 186-359 2.24e-99

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 291.38  E-value: 2.24e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 186 LSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGR--SHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWrN 263
Cdd:pfam00852   1 LPKKTKLVAWVVSNCNTSSARVKYYNELQKHIEVDVYGRcgNLKPLSPGCYLMLISSYKFYLAFENSICKDYITEKLW-N 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512 264 ALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWK 343
Cdd:pfam00852  80 ALLRGAVPVVLGPPRANYERFAPPDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRKHYRVIPLSSWEPFCDLCQK 159

                         170
                  ....*....|....*..
gi 1843978512 344 LQQESR-YQTVRSIAAW 359
Cdd:pfam00852 160 LHRDSRrYKTYPDLAKW 176
Glyco_tran_10_N pfam17039
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 60-170 1.56e-48

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


Pssm-ID: 465336  Cd Length: 109  Bit Score: 159.01  E-value: 1.56e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978512  60 RPTLLILLWTWPFHIPVALSRCSEMVpGTADCHITADRKVYPQADTVIVHHWDImSNPKSRLPPSPRPQGQRWIWFNLEP 139
Cdd:pfam17039   1 KNLKLILLWTWPFGDSFDLLGCSDLF-GITGCRLTYDRSLYPEADAVVFHHRDI-SLDLKDLPYSPRPPGQRWVWFNLES 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1843978512 140 PPNCQHLEALDRYFNLTMSYRSDSDIFTPYG 170
Cdd:pfam17039  79 PTNTPRLPGLDNFFNWTMTYRRDSDIFTPYG 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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