U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    TGOLN2 trans-golgi network protein 2 [ Homo sapiens (human) ]

    Gene ID: 10618, updated on 17-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TGOLN2provided by HGNC
    Official Full Name
    trans-golgi network protein 2provided by HGNC
    Primary source
    HGNC:HGNC:15450
    See related
    Ensembl:ENSG00000152291 MIM:603062; AllianceGenome:HGNC:15450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TGN38; TGN46; TGN48; TGN51; TTGN2; hTGN46; hTGN48; hTGN51
    Summary
    This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Ubiquitous expression in kidney (RPKM 63.9), thyroid (RPKM 61.7) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    2p11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85318027..85327989, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85320018..85329980, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85545150..85555112, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85440681-85441182 Neighboring gene uncharacterized LOC102724579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85442025-85442959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85461879-85462384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85464915-85465420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85465421-85465924 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85482618-85483340 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85483341-85484064 Neighboring gene Sharpr-MPRA regulatory region 427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85486956-85487677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85489661-85490588 Neighboring gene SNRPE pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85517073-85517573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85521502-85522173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85533336-85533836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85536759-85537642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85540508-85541008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85561675-85562174 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2 Neighboring gene retinol saturase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2. Nagashima S, et al. Arch Virol, 2014 May. PMID 24221250
    2. VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay. Subba-Reddy CV, et al. J Virol, 2011 Dec. PMID 21994457, Free PMC Article
    3. Case-control association study of TGOLN2 in attempted suicide. Mahon PB, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468057, Free PMC Article
    4. Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. Kain R, et al. J Biol Chem, 1998 Jan 9. PMID 9422759
    5. Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Höning S, et al. Mol Cell, 2005 May 27. PMID 15916959

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sorting of secretory proteins at the trans-Golgi network by human TGN46.
      Title: Sorting of secretory proteins at the trans-Golgi network by human TGN46.
    2. Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
      Title: Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
    3. These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.
      Title: The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.
    4. These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders.
      Title: Case-control association study of TGOLN2 in attempted suicide.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Case-control association study of TGOLN2 in attempted suicide.
    6. These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos.
      Title: Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.
    7. FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport.
      Title: Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
    Vpu vpu HIV-1 Vpu co-localizes with the trans-golgi network protein TGN46 in CD4+ T cells PubMed
    vpu Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC14722

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    trans-Golgi network integral membrane protein 2
    Names
    TGN38 homolog
    trans-Golgi network glycoprotein 46
    trans-Golgi network glycoprotein 48
    trans-Golgi network glycoprotein 51
    trans-Golgi network protein TGN51

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030379.2 RefSeqGene

      Range
      5308..15270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206840.2 → NP_001193769.1  trans-Golgi network integral membrane protein 2 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. This variant (2, A allele) differs at 1 nt position compared to variant 2, B allele.
      Source sequence(s)
      AA723637, AC093162, AF027516, AL710137, BC008461, BY798185
      UniProtKB/Swiss-Prot
      O43493
      Conserved Domains (1) summary
      PTZ00121
      Location:55 → 330
      PTZ00121; MAEBL; Provisional

    2. NM_001206841.2 → NP_001193770.1  trans-Golgi network integral membrane protein 2 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to isoform 1. This variant (3, A allele) differs at 1 nt position compared to variant 3, B allele.
      Source sequence(s)
      AA723637, AC093162, AL710137, BC008461, BY798185
      UniProtKB/Swiss-Prot
      O43493
      Conserved Domains (1) summary
      PTZ00121
      Location:55 → 330
      PTZ00121; MAEBL; Provisional

    3. NM_001206844.2 → NP_001193773.1  trans-Golgi network integral membrane protein 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001193773.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an in-frame segment of the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AA723637, AC093162, BC008461, BX640868
      Consensus CDS
      CCDS56127.1
      UniProtKB/Swiss-Prot
      O43493
      Related
      ENSP00000381312.2, ENST00000398263.6
      Conserved Domains (1) summary
      PLN03237
      Location:64 → 325
      PLN03237; DNA topoisomerase 2; Provisional

    4. NM_001368095.1 → NP_001355024.1  trans-Golgi network integral membrane protein 2 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, B allele) differs at 1 nt position, resulting in a premature stop codon, compared to variant 2, B allele. The encoded isoform (5) is shorter than isoform 2.
      Source sequence(s)
      AC093162
      Consensus CDS
      CCDS92789.1
      Related
      ENSP00000387035.1, ENST00000409015.5

    5. NM_001368096.1 → NP_001355025.1  trans-Golgi network integral membrane protein 2 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, B allele) differs at 1 nt position compared to variant 3, A allele. The encoded isoform (6) is the same length as isoform 3 but differs in sequence by 1 aa.
      Source sequence(s)
      AC093162
      Consensus CDS
      CCDS56126.1
      UniProtKB/TrEMBL
      A0A5F9UY30
      Related
      ENSP00000386443.3, ENST00000409232.7

    6. NM_006464.4 → NP_006455.2  trans-Golgi network integral membrane protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_006455.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AA723637, AC093162, AL710137, BC008461
      Consensus CDS
      CCDS46351.1
      UniProtKB/Swiss-Prot
      B2R686, B8ZZ88, D6W5K3, F8W8W7, F8WBK2, J3KQ45, O15282, O43492, O43493, O43499, O43500, O43501, Q53G68, Q53GV2, Q6MZV1, Q6ZTM7, Q8N6T8, Q92760, Q96QL2
      Related
      ENSP00000366603.3, ENST00000377386.8
      Conserved Domains (2) summary
      pfam17818
      Location:306 → 435
      KCT2; Keratinocyte-associated gene product
      NF000535
      Location:40 → 274
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85318027..85327989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791763.1 Reference GRCh38.p14 PATCHES

      Range
      244268..254227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85320018..85329980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43493.4 GenPept UniProtKB/Swiss-Prot:O43493

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous