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ARMC10 armadillo repeat containing 10 [ Homo sapiens (human) ]

Gene ID: 83787, updated on 7-Apr-2024

Summary

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Official Symbol
ARMC10provided by HGNC
Official Full Name
armadillo repeat containing 10provided by HGNC
Primary source
HGNC:HGNC:21706
See related
Ensembl:ENSG00000170632 MIM:611864; AllianceGenome:HGNC:21706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SVH; PNAS112; PNAS-112; PSEC0198
Summary
This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in thyroid (RPKM 11.8), adrenal (RPKM 9.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (103075140..103099759)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (104390254..104414903)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102715587..102740206)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:102580673-102581173 Neighboring gene leucine rich repeat containing 17 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:102584236-102584801 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:102613398-102614597 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:102616989-102617150 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:102631963-102633162 Neighboring gene nuclear factor, erythroid 4 Neighboring gene Sharpr-MPRA regulatory region 7515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102746161-102747030 Neighboring gene crystallin zeta pseudogene 1 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L19 pseudogene 12 Neighboring gene ribosomal protein L23a pseudogene 95

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Chen Z, et al. Nat Commun, 2019 Jan 10. PMID 30631047, Free PMC Article
  2. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Huang R, et al. Cancer Res, 2003 Jul 1. PMID 12839973
  3. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. Zhou X, et al. FEBS Lett, 2007 Oct 16. PMID 17904127
  4. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
  5. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. Dall'Era MA, et al. Prostate, 2007 May 15. PMID 17342744

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
    Title: The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
  2. Data show that the serine S45 site of armadillo repeat containing 10 (ARMC10) can be phosphorylated by AMP-activated protein kinase (AMPK) both in vitro and in vivo. .
    Title: Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. a novel gene SVH, up-regulated in hepatocellular carcinoma, was identified; four variants SVH-A, -B, -C, and -D, resulting from alternative splicing in the coding region of the SVH transcript, were observed and localized in the endoplasmic reticulum
    Title: A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3195, FLJ37850

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
armadillo repeat-containing protein 10
Names
specific splicing variant involved in hepatocarcinogenesis
splicing variant involved in hepatocarcinogenesis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030014.1 RefSeqGene

    Range
    5260..29879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161009.3 → NP_001154481.1  armadillo repeat-containing protein 10 isoform b

    See identical proteins and their annotated locations for NP_001154481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region compared to variant A. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, AY150853, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55146.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000413619.2, ENST00000441711.6
    Conserved Domains (3) summary
    cd00020
    Location:55 → 140
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52 → 302
    Arm_2; Armadillo-like
    sd00043
    Location:56 → 84
    ARM; armadillo repeat [structural motif]

  2. NM_001161010.3 → NP_001154482.1  armadillo repeat-containing protein 10 isoform c

    See identical proteins and their annotated locations for NP_001154482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) lacks an in-frame exon in the 3' coding region compared to variant A. This results in a shorter protein (isoform c) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, AY150852, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55145.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000396654.2, ENST00000428183.6
    Conserved Domains (3) summary
    cd00020
    Location:90 → 186
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:87 → 278
    Arm_2; Armadillo-like
    sd00043
    Location:91 → 119
    ARM; armadillo repeat [structural motif]

  3. NM_001161011.3 → NP_001154483.1  armadillo repeat-containing protein 10 isoform e

    See identical proteins and their annotated locations for NP_001154483.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform e) compared to isoform a.
    Source sequence(s)
    AI761577, AK301565, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55147.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000397969.1, ENST00000425331.5
    Conserved Domains (3) summary
    cd00020
    Location:55 → 140
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52 → 278
    Arm_2; Armadillo-like
    sd00043
    Location:56 → 84
    ARM; armadillo repeat [structural motif]

  4. NM_001161012.3 → NP_001154484.1  armadillo repeat-containing protein 10 isoform d

    See identical proteins and their annotated locations for NP_001154484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform d) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55148.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000405612.1, ENST00000454559.5
    Conserved Domains (3) summary
    cd00020
    Location:55 → 151
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52 → 243
    Arm_2; Armadillo-like
    sd00043
    Location:56 → 84
    ARM; armadillo repeat [structural motif]

  5. NM_001161013.3 → NP_001154485.1  armadillo repeat-containing protein 10 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) lacks three in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform f) compared to isoform a.
    Source sequence(s)
    AF275808, AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55149.1
    UniProtKB/TrEMBL
    C9J5N7
    Related
    ENSP00000440463.1, ENST00000541300.5
    Conserved Domains (3) summary
    cd00020
    Location:55 → 169
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52 → 219
    Arm_2; Armadillo-like
    sd00043
    Location:56 → 84
    ARM; armadillo repeat [structural motif]

  6. NM_031905.5 → NP_114111.2  armadillo repeat-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_114111.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI761577, AY150851, AY150854, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS5728.1
    UniProtKB/Swiss-Prot
    A8K703, B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q8N2F6, Q9BTM6
    Related
    ENSP00000319412.3, ENST00000323716.8
    Conserved Domains (3) summary
    cd00020
    Location:90 → 175
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:87 → 337
    Arm_2; Armadillo-like
    sd00043
    Location:91 → 119
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    103075140..103099759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516601.4 → XP_011514903.1  armadillo repeat-containing protein 10 isoform X8

    Conserved Domains (3) summary
    cd00020
    Location:63 → 148
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:60 → 310
    Arm_2; Armadillo-like
    sd00043
    Location:64 → 92
    ARM; armadillo repeat [structural motif]

  2. XM_047420912.1 → XP_047276868.1  armadillo repeat-containing protein 10 isoform X1

  3. XM_047420914.1 → XP_047276870.1  armadillo repeat-containing protein 10 isoform X3

  4. XM_047420915.1 → XP_047276871.1  armadillo repeat-containing protein 10 isoform X6

  5. XM_047420913.1 → XP_047276869.1  armadillo repeat-containing protein 10 isoform X2

  6. XM_047420917.1 → XP_047276873.1  armadillo repeat-containing protein 10 isoform X9

  7. XM_017012684.3 → XP_016868173.1  armadillo repeat-containing protein 10 isoform X4

    Conserved Domains (3) summary
    cd00020
    Location:99 → 184
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:96 → 346
    Arm_2; Armadillo-like
    sd00043
    Location:100 → 128
    ARM; armadillo repeat [structural motif]

  8. XM_017012685.3 → XP_016868174.1  armadillo repeat-containing protein 10 isoform X5

  9. XM_047420916.1 → XP_047276872.1  armadillo repeat-containing protein 10 isoform X7

  10. XM_017012688.3 → XP_016868177.1  armadillo repeat-containing protein 10 isoform X10

  11. XM_005250628.4 → XP_005250685.1  armadillo repeat-containing protein 10 isoform X11

    UniProtKB/TrEMBL
    H7BXQ8
    Related
    ENSP00000319798.6, ENST00000323735.10
    Conserved Domains (2) summary
    cd00020
    Location:90 → 175
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:91 → 119
    ARM; armadillo repeat [structural motif]

  12. XM_047420918.1 → XP_047276874.1  armadillo repeat-containing protein 10 isoform X10

  13. XM_017012689.3 → XP_016868178.1  armadillo repeat-containing protein 10 isoform X12

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187559.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    144970..158099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    104390254..104414903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359163.1 → XP_054215138.1  armadillo repeat-containing protein 10 isoform X8

  2. XM_054359156.1 → XP_054215131.1  armadillo repeat-containing protein 10 isoform X1

  3. XM_054359158.1 → XP_054215133.1  armadillo repeat-containing protein 10 isoform X3

  4. XM_054359161.1 → XP_054215136.1  armadillo repeat-containing protein 10 isoform X6

  5. XM_054359157.1 → XP_054215132.1  armadillo repeat-containing protein 10 isoform X2

  6. XM_054359164.1 → XP_054215139.1  armadillo repeat-containing protein 10 isoform X9

  7. XM_054359159.1 → XP_054215134.1  armadillo repeat-containing protein 10 isoform X4

  8. XM_054359160.1 → XP_054215135.1  armadillo repeat-containing protein 10 isoform X5

  9. XM_054359162.1 → XP_054215137.1  armadillo repeat-containing protein 10 isoform X7

  10. XM_054359166.1 → XP_054215141.1  armadillo repeat-containing protein 10 isoform X10

  11. XM_054359167.1 → XP_054215142.1  armadillo repeat-containing protein 10 isoform X11

    UniProtKB/TrEMBL
    H7BXQ8

  12. XM_054359165.1 → XP_054215140.1  armadillo repeat-containing protein 10 isoform X10

  13. XM_054359168.1 → XP_054215143.1  armadillo repeat-containing protein 10 isoform X12

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N2F6.1 GenPept UniProtKB/Swiss-Prot:Q8N2F6

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