3AU3,1XQS,1BK6,1BK6,1BK6,1BK6,1I7X,1I7X,1I7X,1IAL,1IAL,1IAL,1IAL,1JPW,1JPW,1JPW,1JPW,1JPW,1JPW,1LUJ,2JDQ,2JDQ,2JDQ,2JDQ,2YNS,2YNS,2YNS,2Z6G,2Z6G,2Z6G,2Z6G,2Z6G,2Z6H,1XM9,3FEX,3FEX,3FEX,3FEX,3IFQ,3IFQ,3IFQ,3IFQ,3L3F,3L6X,3L6X,3L6X,3NMZ,3SL9,3SLA,3SLA,4B8J,4DB9,4DB9,4DB9


Conserved Protein Domain Family
ARM
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sd00043: ARM 
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armadillo repeat
Armadillo (ARM)/beta-catenin-like repeats are approximately 40 amino acid long, tandemly repeated sequence motif, first identified in the Drosophila segment polarity gene armadillo. These repeats were also found in the mammalian armadillo homolog beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumor suppressor protein, and a number of other proteins. ARM has been implicated in mediating protein-protein interactions, but no common features among the target proteins recognized by the ARM repeats have been identified. ARM repeats are related to HEAT repeats.
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Statistics
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PSSM-Id: 293788
Aligned: 54 rows
Threshold Bit Score: 54.9248
Created: 29-May-2013
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:creates a ridge that spans the concave surface
  • Structure:1IAL; mouse importin alpha, autoinhibition by an internal NLS, contacts 4A
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  • Structure:1BK6; Saccharomyces cerevisiae NLS peptide bound to importin-alpha, contacts 4A
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  • Citation:PMID 9695948
  • Structure:1JPW; Homo sapiens beta-catenin with bound Tcf-1, contacts 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        #   #   #                                    
3AU3_A    174 TLRevgsVKALXECALevk-----------kesTLKSVLSALWNLsahctenKADICAvdGALAFLVGTLTyrsqtnTLA 242 human
1XQS_A      8 RGEve-qMKSCLRVLSqpmpptageaeqaadqqEREGALELLADLcen-mdnAADFCQl-SGMHLLVGRYLea---gAAG 81  human
1I7X_A    181 IILasggPQALVNIMRtyt-----------yekLLWTTSRVLKVLsvc-ssnKPAIVEa-GGMQALGLHLTd----pSQR 243 house mouse
1IAL_A     71 NIIraglIPKFVSFLGktd-----------cspIQFESAWALTNIasgtseqTKAVVDg-GAIPAFISLLAs----pHAH 134 house mouse
1IAL_A    205 AVEq--iLPTLVRLLHhnd------------peVLADSCWAISYLtdgpnerIEMVVKk-GVVPQLVKLLGa----tELP 265 house mouse
1IAL_A    287 KVIdagaLAVFPSLLTnpk------------tnIQKEATWTMSNItagrqdqIQQVVNh-GLVPFLVGVLSk----aDFK 349 house mouse
1IAL_A    245 MVVkkgvVPQLVKLLGate------------lpIVTPALRAIGNIvtgtdeqTQKVIDa-GALAVFPSLLTn----pKTN 307 house mouse
2Z6G_A    313 IILasggPQALVNIMRtyt-----------yekLLWTTSRVLKVLsvc-ssnKPAIVEa-GGMQALGLHLTd----pSQR 375 zebrafish
2Z6H_A    177 IILasggPQALVNIMRtyt-----------yekLLWTTSRVLKVLsvc-ssnKPAIVEa-GGMQALGLHLTd----pSQR 239 human
1XM9_A      1 GLT----IPKAVQYLSsqd------------ekYQAIGAYYIQHTcfqdesaKQQVYQl-GGICKLVDLLRs----pNQN 59  human

Feature 1       #   #   #                                         #   #   # 
3AU3_A    243 IIESGGGILRNVSSliatnedhRQILREnncLQTLLQHLksh-----sltIVSNACGTLWNL 299 human
1XQS_A     82 LRWRAAQLIGTCSQnva---aiQEQVLGlgaLRKLLRLLdrda----cdtVRVKALFAISCL 136 human
1I7X_A    244 LVQNCLWTLRNLSDaa----tkQEGMEGl--LGTLVQLLgsd-----dinVVTCAAGILSNL 294 house mouse
1IAL_A    135 ISEQAVWALGNIAGdgs---afRDLVIKhgaIDPLLALLavpdlstlacgYLRNLTWTLSNL 193 house mouse
1IAL_A    266 IVTPALRAIGNIVTgtd---eqTQKVIDagaLAVFPSLLtnp-----ktnIQKEATWTMSNI 319 house mouse
1IAL_A    350 TQKEAAWAITNYTSggt--veqIVYLVHcgiIEPLMNLLsak-----dtkIIQVILDAISNI 404 house mouse
1IAL_A    308 IQKEATWTMSNITAgrq---dqIQQVVNhglVPFLVGVLska-----dfkTQKEAAWAITNY 361 house mouse
2Z6G_A    376 LVQNCLWTLRNLSDaa----tkQEGMEGl--LGTLVQLLgsd-----dinVVTCAAGILSNL 426 zebrafish
2Z6H_A    240 LVQNCLWTLRNLSDaa----tkQEGMEGl--LGTLVQLLgsd-----dinVVTCAAGILSNL 290 human
1XM9_A     60 VQQAAAGALRNLVFrst---tnKLETRRqngIREAVSLLrrtg----naeIQKQLTGLLWNL 114 human

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