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ZNF790 zinc finger protein 790 [ Homo sapiens (human) ]

Gene ID: 388536, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF790provided by HGNC
Official Full Name
zinc finger protein 790provided by HGNC
Primary source
HGNC:HGNC:33114
See related
Ensembl:ENSG00000197863 AllianceGenome:HGNC:33114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.2), kidney (RPKM 1.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36817428..36850792, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39493114..39526474, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37308330..37341694, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 850 Neighboring gene Sharpr-MPRA regulatory region 9870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14533 Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene zinc finger protein 345 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20350, MGC62100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 790

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242800.2 → NP_001229729.1  zinc finger protein 790

    See identical proteins and their annotated locations for NP_001229729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents a distinct first exon and 5' UTR.
    Source sequence(s)
    AC008733, AC020928, AK297474, DC308617, EL735861
    Consensus CDS
    CCDS12496.1
    UniProtKB/Swiss-Prot
    Q6PG37
    Related
    ENSP00000480764.1, ENST00000613249.4
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001242801.2 → NP_001229730.1  zinc finger protein 790

    See identical proteins and their annotated locations for NP_001229730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents a distinct first exon and 5' UTR.
    Source sequence(s)
    AC020928, AK297474, BF132049, DC307556, DC352882, DC377558
    Consensus CDS
    CCDS12496.1
    UniProtKB/Swiss-Prot
    Q6PG37
    Related
    ENSP00000480834.1, ENST00000614179.4
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001242802.2 → NP_001229731.1  zinc finger protein 790

    See identical proteins and their annotated locations for NP_001229731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents a distinct first exon and 5' UTR.
    Source sequence(s)
    AC020928, AK297474, DC324605
    Consensus CDS
    CCDS12496.1
    UniProtKB/Swiss-Prot
    Q6PG37
    Related
    ENSP00000478852.1, ENST00000615484.4
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_206894.4 → NP_996777.2  zinc finger protein 790

    See identical proteins and their annotated locations for NP_996777.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a distinct first exon.
    Source sequence(s)
    AC020928, AK297474, BM473790
    Consensus CDS
    CCDS12496.1
    UniProtKB/Swiss-Prot
    Q6PG37
    Related
    ENSP00000349161.3, ENST00000356725.9
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36817428..36850792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438800.1 → XP_047294756.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  2. XM_005258903.6 → XP_005258960.1  zinc finger protein 790 isoform X2

    See identical proteins and their annotated locations for XP_005258960.1

    UniProtKB/Swiss-Prot
    Q6PG37
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047438799.1 → XP_047294755.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  4. XM_011526950.4 → XP_011525252.1  zinc finger protein 790 isoform X2

    See identical proteins and their annotated locations for XP_011525252.1

    UniProtKB/Swiss-Prot
    Q6PG37
    Conserved Domains (3) summary
    smart00349
    Location:5 → 64
    KRAB; krueppel associated box
    COG5048
    Location:308 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:284 → 304
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047438801.1 → XP_047294757.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  6. XM_047438798.1 → XP_047294754.1  zinc finger protein 790 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39493114..39526474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320957.1 → XP_054176932.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  2. XM_054320955.1 → XP_054176930.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  3. XM_054320954.1 → XP_054176929.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  4. XM_054320956.1 → XP_054176931.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  5. XM_054320958.1 → XP_054176933.1  zinc finger protein 790 isoform X2

    UniProtKB/Swiss-Prot
    Q6PG37

  6. XM_054320953.1 → XP_054176928.1  zinc finger protein 790 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PG37.2 GenPept UniProtKB/Swiss-Prot:Q6PG37

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