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Conserved domains on  [gi|338797724|ref|NP_001229730|]
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zinc finger protein 790 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-64 2.79e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 2.79e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724     5 MMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLGFCIYQPEAFSLLEKGKEPW 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-575 1.19e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 308 KPYECNECRKAFSQRSHLIKHQRIHTGEKPYEC--KECGKAFTRGSHLTQHQRIHTGEKSHECK---------------- 369
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 370 ECGKAFIRGSNLAQHQNVHVGRKP-------------------YKCEKCGKAYIWSSHLARHQRIHTGRKPYECKQCGKT 430
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnnplpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 431 FTWASY----------------LAQHEKIHNERKSYECKECGKTFLHGSEFNRHQKIHTGERNYECKECG------KTFF 488
Cdd:COG5048  192 VSTSIPsssensplsssysipsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 489 RGSELNRHQKIHTGKR-PYECEECGKAFLWGSQLTRHQRM--HTGE--EPYVCKE--CGKSFIWGSQLTRHKKIHTDAEP 561
Cdd:COG5048  272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....
gi 338797724 562 YGCKKSSHIFSHHS 575
Cdd:COG5048  352 AKEKLLNSSSKFSP 365
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
183-361 1.40e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 183 SDHTQHQLIHTSEKfCGDKECGNTFLPDSeviQYQTVHTVK--KTYECKE--CGKSFSLRSSLTGHKRIHTGEKPFKCKd 258
Cdd:COG5048  281 SSEKGFSLPIKSKQ-CNISFSRSSPLTRH---LRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 259 cgkafrfhsqLSVHKRIHTGEKsyeckecgkaFSCGSDLTRHQRIHTGEKPYEC--NECRKAFSQRSHLIKHQRIHTGEK 336
Cdd:COG5048  356 ----------LLNSSSKFSPLL----------NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415

                        170       180
                 ....*....|....*....|....*..
gi 338797724 337 PYECK--ECGKAFTRGSHLTQHQRIHT 361
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-64 2.79e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 2.79e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724     5 MMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLGFCIYQPEAFSLLEKGKEPW 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 4.64e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 4.64e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 338797724    4 LMMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-44 5.22e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.06  E-value: 5.22e-21
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 338797724   7 FRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSL 44
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-575 1.19e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 308 KPYECNECRKAFSQRSHLIKHQRIHTGEKPYEC--KECGKAFTRGSHLTQHQRIHTGEKSHECK---------------- 369
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 370 ECGKAFIRGSNLAQHQNVHVGRKP-------------------YKCEKCGKAYIWSSHLARHQRIHTGRKPYECKQCGKT 430
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnnplpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 431 FTWASY----------------LAQHEKIHNERKSYECKECGKTFLHGSEFNRHQKIHTGERNYECKECG------KTFF 488
Cdd:COG5048  192 VSTSIPsssensplsssysipsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 489 RGSELNRHQKIHTGKR-PYECEECGKAFLWGSQLTRHQRM--HTGE--EPYVCKE--CGKSFIWGSQLTRHKKIHTDAEP 561
Cdd:COG5048  272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....
gi 338797724 562 YGCKKSSHIFSHHS 575
Cdd:COG5048  352 AKEKLLNSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 338797724  324 HLIKHQRIHTGEKPYECKECGKAFTR 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-361 1.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 183 SDHTQHQLIHTSEKfCGDKECGNTFLPDSeviQYQTVHTVK--KTYECKE--CGKSFSLRSSLTGHKRIHTGEKPFKCKd 258
Cdd:COG5048  281 SSEKGFSLPIKSKQ-CNISFSRSSPLTRH---LRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 259 cgkafrfhsqLSVHKRIHTGEKsyeckecgkaFSCGSDLTRHQRIHTGEKPYEC--NECRKAFSQRSHLIKHQRIHTGEK 336
Cdd:COG5048  356 ----------LLNSSSKFSPLL----------NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415

                        170       180
                 ....*....|....*....|....*..
gi 338797724 337 PYECK--ECGKAFTRGSHLTQHQRIHT 361
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-293 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 338797724  269 LSVHKRIHTGEKSYECKECGKAFSC 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-64 2.79e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 2.79e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724     5 MMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLGFCIYQPEAFSLLEKGKEPW 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 4.64e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.84  E-value: 4.64e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 338797724    4 LMMFRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-44 5.22e-21

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 86.06  E-value: 5.22e-21
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 338797724   7 FRDVAVDFSQEEWECLDLEQRDLYRDVMLENYSNMVSL 44
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
308-575 1.19e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 308 KPYECNECRKAFSQRSHLIKHQRIHTGEKPYEC--KECGKAFTRGSHLTQHQRIHTGEKSHECK---------------- 369
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 370 ECGKAFIRGSNLAQHQNVHVGRKP-------------------YKCEKCGKAYIWSSHLARHQRIHTGRKPYECKQCGKT 430
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnnplpgnNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 431 FTWASY----------------LAQHEKIHNERKSYECKECGKTFLHGSEFNRHQKIHTGERNYECKECG------KTFF 488
Cdd:COG5048  192 VSTSIPsssensplsssysipsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 489 RGSELNRHQKIHTGKR-PYECEECGKAFLWGSQLTRHQRM--HTGE--EPYVCKE--CGKSFIWGSQLTRHKKIHTDAEP 561
Cdd:COG5048  272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....
gi 338797724 562 YGCKKSSHIFSHHS 575
Cdd:COG5048  352 AKEKLLNSSSKFSP 365
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-513 3.18e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 265 FHSQLSVHKRIHTGEKSYECKECGKAFSCGSDLTRHQRIHTGEKPYECNECRKAFSQRSHLIKHQRIHTGEKPYECKECG 344
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 345 KAF--TRGSHLTQHQRIHTGE-----KSHECKECGKAFIRGSNLAQHQN--VHVG--RKPYKC--EKCGKAYIWSSHLAR 411
Cdd:COG5048  262 RSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKR 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 412 HQRIHTGRKPYECK--QCGKTFTWAS------YLAQHEKIHNERK---SYECKECGKTFLHGSEFNRHQKIHTGERNYEC 480
Cdd:COG5048  342 HILLHTSISPAKEKllNSSSKFSPLLnneppqSLQQYKDLKNDKKsetLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKN 421

                        250       260       270
                 ....*....|....*....|....*....|...
gi 338797724 481 KECGKTFFRGSELNRHQKIHTGKRPYECEECGK 513
Cdd:COG5048  422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 338797724  324 HLIKHQRIHTGEKPYECKECGKAFTR 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-321 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 338797724  296 DLTRHQRIHTGEKPYECNECRKAFSQ 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*
gi 338797724  408 HLARHQRIHTGRKPYECKQCGKTFT 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-515 7.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.72e-04
                          10        20
                  ....*....|....*....|....
gi 338797724  492 ELNRHQKIHTGKRPYECEECGKAF 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-377 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 338797724  352 HLTQHQRIHTGEKSHECKECGKAFIR 377
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-361 1.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 183 SDHTQHQLIHTSEKfCGDKECGNTFLPDSeviQYQTVHTVK--KTYECKE--CGKSFSLRSSLTGHKRIHTGEKPFKCKd 258
Cdd:COG5048  281 SSEKGFSLPIKSKQ-CNISFSRSSPLTRH---LRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK- 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 259 cgkafrfhsqLSVHKRIHTGEKsyeckecgkaFSCGSDLTRHQRIHTGEKPYEC--NECRKAFSQRSHLIKHQRIHTGEK 336
Cdd:COG5048  356 ----------LLNSSSKFSPLL----------NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415

                        170       180
                 ....*....|....*....|....*..
gi 338797724 337 PYECK--ECGKAFTRGSHLTQHQRIHT 361
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-293 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 338797724  269 LSVHKRIHTGEKSYECKECGKAFSC 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-263 2.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.99e-03
                          10        20
                  ....*....|....*....|
gi 338797724  244 HKRIHTGEKPFKCKDCGKAF 263
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
521-543 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|...
gi 338797724  521 LTRHQRMHTGEEPYVCKECGKSF 543
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
503-635 5.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338797724 503 KRPYECEECGKAFLWGSQLTRHQRMHTGEEPYVC--KECGKSFIWGSQLTRHKKIHT----DAEPYGCKKSSHIFSHHSY 576
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHnnpsDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 338797724 577 FTEQKIHNSANLCEwtdyGNTFSHESNFAQHQNIYTFEKSYEFKDFEKAFSSSSHFISL 635
Cdd:COG5048  111 SSSSSNSNDNNLLS----SHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN 165
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 310-332 7.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|...
gi 338797724  310 YECNECRKAFSQRSHLIKHQRIH 332
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-487 8.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.65e-03
                          10        20
                  ....*....|....*....|....
gi 338797724  464 EFNRHQKIHTGERNYECKECGKTF 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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