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FCRLB Fc receptor like B [ Homo sapiens (human) ]

Gene ID: 127943, updated on 11-Apr-2024

Summary

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Official Symbol
FCRLBprovided by HGNC
Official Full Name
Fc receptor like Bprovided by HGNC
Primary source
HGNC:HGNC:26431
See related
Ensembl:ENSG00000162746 MIM:609251; AllianceGenome:HGNC:26431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2
Summary
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161721544..161728143)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161065867..161072464)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161691334..161697933)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene Fc receptor like A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2000 Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2005 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161719946-161720592 Neighboring gene dual specificity phosphatase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the human FCRL2 gene. Chikaev NA, et al. Genomics, 2005 Feb. PMID 15676285
  2. FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy. Zhou XJ, et al. PLoS One, 2013. PMID 23593433, Free PMC Article
  3. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Masuda K, et al. Gene, 2005 Dec 19. PMID 16263223
  4. A new Fc receptor homolog, FREB2, found in germinal center B cells. Wilson TJ, et al. Genes Immun, 2005 Jun. PMID 15815692
  5. The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. Taylor AI, et al. Immunogenetics, 2007 Apr. PMID 17273841

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The aim of the study was to associate multiple polymorphisms within FCGR gene locus with IgA nephropathy in a large Chinese cohort.
    Title: FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene variants associated with ischemic stroke: the cardiovascular health study.
  3. Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation
    Title: FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
  4. Expression analysis revealed FCRL2 mRNA only in placenta.FCRL2 is differentially expressed by transformed B cell lines.
    Title: Cloning and characterization of the human FCRL2 gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31052, RP11-474I16.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fc receptor-like B
Names
fc receptor homolog expressed in B cells protein 2
fc receptor-like and mucin-like protein 2
fc receptor-like protein 2
fc receptor-related protein Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002901.4 → NP_001002901.1  Fc receptor-like B isoform 1 precursor

    See identical proteins and their annotated locations for NP_001002901.1

    Status: VALIDATED

    Source sequence(s)
    AL359541
    Consensus CDS
    CCDS30927.1
    UniProtKB/Swiss-Prot
    A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7
    Related
    ENSP00000356925.2, ENST00000367948.7
    Conserved Domains (3) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104 → 186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114 → 190
    IG_like; Immunoglobulin like

  2. NM_001288829.1 → NP_001275758.1  Fc receptor-like B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001275758.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as hFCRL2c1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670684, BQ014014, DQ021957
    Consensus CDS
    CCDS72963.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356923.3, ENST00000367946.7
    Conserved Domains (3) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104 → 186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114 → 190
    IG_like; Immunoglobulin like

  3. NM_001288830.1 → NP_001275759.1  Fc receptor-like B isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as hFCRL2c2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670685, BQ014014, BX364259, DQ021957
    Consensus CDS
    CCDS72965.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356922.1, ENST00000367945.5
    Conserved Domains (3) summary
    cd05752
    Location:16 → 93
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:97 → 179
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:107 → 183
    IG_like; Immunoglobulin like

  4. NM_001288831.1 → NP_001275760.1  Fc receptor-like B isoform 4 precursor

    See identical proteins and their annotated locations for NP_001275760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as hFCRL2b1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670686, BQ014014, DQ021957
    Consensus CDS
    CCDS72962.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000338598.5, ENST00000336830.9
    Conserved Domains (3) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104 → 186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114 → 190
    IG_like; Immunoglobulin like

  5. NM_001288832.1 → NP_001275761.1  Fc receptor-like B isoform 5 precursor

    See identical proteins and their annotated locations for NP_001275761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as hFCRL2b2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670687, BQ014014, BX364259, DQ021957
    Consensus CDS
    CCDS72964.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356921.3, ENST00000367944.3
    Conserved Domains (3) summary
    cd05752
    Location:16 → 93
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:97 → 179
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:107 → 183
    IG_like; Immunoglobulin like

  6. NM_001320241.1 → NP_001307170.1  Fc receptor-like B isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AK290733, AY670683, BQ014014
    Consensus CDS
    CCDS30927.1
    UniProtKB/Swiss-Prot
    A2A3J5, A2A3J7, Q5VXA6, Q6BAA0, Q6BAA1, Q6BAA2, Q6BAA3, Q6BAA4, Q8IXZ7
    Conserved Domains (3) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104 → 186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114 → 190
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161721544..161728143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    161065867..161072464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152378.1: Suppressed sequence

    Description
    NM_152378.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6BAA4.1 GenPept UniProtKB/Swiss-Prot:Q6BAA4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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