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Conserved domains on  [gi|572152983|ref|NP_001275760|]
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Fc receptor-like B isoform 4 precursor [Homo sapiens]

Protein Classification

Ig1_FcgammaR_like and Ig2_FcgammaR_like domain-containing protein( domain architecture ID 10146245)

Ig1_FcgammaR_like and Ig2_FcgammaR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 3.20e-41

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409411  Cd Length: 83  Bit Score: 137.05  E-value: 3.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983 104 WLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIpvesAPMFS 183
Cdd:cd05753    1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                 ....*..
gi 572152983 184 AKVAVTV 190
Cdd:cd05753   77 ESVNITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 23-100 7.16e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


:

Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 117.85  E-value: 7.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983  23 PILSLHPPWTTIFKGERVTLKCDGYHPllleLQPISTLWYLGHLLLPSHKKSIE-----VQTPGVYRCQTRGAPVSDPIH 97
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRivaatVNDSGEYRCQTQGSSLSDPVH 76


                 ...
gi 572152983  98 LSV 100
Cdd:cd05752   77 LEV 79
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 3.20e-41

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 137.05  E-value: 3.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983 104 WLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIpvesAPMFS 183
Cdd:cd05753    1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                 ....*..
gi 572152983 184 AKVAVTV 190
Cdd:cd05753   77 ESVNITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 23-100 7.16e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 117.85  E-value: 7.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983  23 PILSLHPPWTTIFKGERVTLKCDGYHPllleLQPISTLWYLGHLLLPSHKKSIE-----VQTPGVYRCQTRGAPVSDPIH 97
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRivaatVNDSGEYRCQTQGSSLSDPVH 76


                 ...
gi 572152983  98 LSV 100
Cdd:cd05752   77 LEV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 104-190 6.38e-13

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 62.80  E-value: 6.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983  104 WLILQVPYAPVFEGEPLVLRCRGWyDKVVYKLHYYHDGQAVRyfhSSANYTVLQARASDSGRYQCSGTMripvESAPMFS 183
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVARN----GRGGKVS 72


                  ....*..
gi 572152983  184 AKVAVTV 190
Cdd:pfam13895  73 NPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 22-100 1.15e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983   22 KPILSLHPpwTTIFKGERVTLKCDGYHPlllelQPISTLWYLGHLLLPSHK----KSIEVQTPGVYRCQ---TRGAPVSD 94
Cdd:pfam13895   1 KPVLTPSP--TVVTEGEPVTLTCSAPGN-----PPPSYTWYKDGSAISSSPnfftLSVSAEDSGTYTCVarnGRGGKVSN 73


                  ....*.
gi 572152983   95 PIHLSV 100
Cdd:pfam13895  74 PVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 114-190 2.25e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 2.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983   114 VFEGEPLVLRCRGWYDKVVYkLHYYHDGQA---------VRYFHSSANYTVLQARASDSGRYQCSGTmripvESAPMFSA 184
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPE-VTWYKQGGKllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAAT-----NSSGSASS 79


                   ....*.
gi 572152983   185 KVAVTV 190
Cdd:smart00410  80 GTTLTV 85
 
Name Accession Description Interval E-value
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 104-190 3.20e-41

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 137.05  E-value: 3.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983 104 WLILQVPYAPVFEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRIpvesAPMFS 183
Cdd:cd05753    1 WLLLQAPSAVVFEGEPLTLRCHGWKDKKVHKVTYYKDGKALKFSYENSNFSIPQATLSDSGSYHCSGTVRI----KRRSS 76


                 ....*..
gi 572152983 184 AKVAVTV 190
Cdd:cd05753   77 ESVNITV 83
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 23-100 7.16e-34

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 117.85  E-value: 7.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983  23 PILSLHPPWTTIFKGERVTLKCDGYHPllleLQPISTLWYLGHLLLPSHKKSIE-----VQTPGVYRCQTRGAPVSDPIH 97
Cdd:cd05752    1 AVVSLDPPWTTVFQGEKVTLTCQGFYS----PEQNSTQWYHNGTLISSTSSSYRivaatVNDSGEYRCQTQGSSLSDPVH 76


                 ...
gi 572152983  98 LSV 100
Cdd:cd05752   77 LEV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 104-190 6.38e-13

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 62.80  E-value: 6.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983  104 WLILQVPYAPVFEGEPLVLRCRGWyDKVVYKLHYYHDGQAVRyfhSSANYTVLQARASDSGRYQCSGTMripvESAPMFS 183
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAP-GNPPPSYTWYKDGSAIS---SSPNFFTLSVSAEDSGTYTCVARN----GRGGKVS 72


                  ....*..
gi 572152983  184 AKVAVTV 190
Cdd:pfam13895  73 NPVELTV 79
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 22-100 1.15e-08

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 50.86  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983   22 KPILSLHPpwTTIFKGERVTLKCDGYHPlllelQPISTLWYLGHLLLPSHK----KSIEVQTPGVYRCQ---TRGAPVSD 94
Cdd:pfam13895   1 KPVLTPSP--TVVTEGEPVTLTCSAPGN-----PPPSYTWYKDGSAISSSPnfftLSVSAEDSGTYTCVarnGRGGKVSN 73


                  ....*.
gi 572152983   95 PIHLSV 100
Cdd:pfam13895  74 PVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 114-190 2.25e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 2.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572152983   114 VFEGEPLVLRCRGWYDKVVYkLHYYHDGQA---------VRYFHSSANYTVLQARASDSGRYQCSGTmripvESAPMFSA 184
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPE-VTWYKQGGKllaesgrfsVSRSGSTSTLTISNVTPEDSGTYTCAAT-----NSSGSASS 79


                   ....*.
gi 572152983   185 KVAVTV 190
Cdd:smart00410  80 GTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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