GEO DataSets

Analysis of non-lesional epidermal samples from individuals with atopic dermatitis (AD). AD is characterized by dry eczematous skin lesions, a relapsing and often chronic course, and an intense intractable pruritus. Results provide insight into the molecular pathogenesis of AD.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state sets

Platform:

GPL2700

Series:

GSE26952

16 Samples

Download data

(Submitter supplied) The expression and function of tight junction genes, in particular claudin-1, was studied in order to further understanding of the biology underlying atopic dermatitis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3806

Platform:

GPL2700

16 Samples

Download data: TXT

(Submitter supplied) Background: While atopic dermatitis (AD) often starts in early childhood, detailed tissue profiling of early-onset AD in children is lacking, hindering therapeutic development for this patient population with a particularly high unmet need of better treatments. Objective: We sought to globally profile the skin of infants with AD compared to adults with AD and healthy controls. Methods: We performed microarray, RT-PCR and fluorescence microscopy studies in infants and young children (<5yo) with early-onset AD (<6mo) compared to age-matched controls and adults with longstanding AD. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

108 Samples

Download data: CEL

(Submitter supplied) The morphology and the behavior of skin and oral tissue keratinocytes are different. One significant dissimilarity between the two sites is the response to injury. Oral and skin keratinocytes have intrinsic differences in the response to injury and such differences are reflected in gene expression profiles. We used microarrays to investigate differences in global gene expression patterns between baseline skin and oral epithelium sheets without their underlying connective tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

8 Samples

Download data: CEL

(Submitter supplied) When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5239 GDS5240

Platform:

GPL1261

48 Samples

Download data: CEL

Analysis of oral mucosae of tongues recovering from injury for up to 10 days following wounding inflicted via punch biopsy. Results compared to those from injured skin (GDS5239) and provide insight into the molecular differences in wound healing between the skin and oral mucosa.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 stress, 8 time sets

Platform:

GPL1261

Series:

GSE23006

24 Samples

Download data: CEL

Analysis of skin samples recovering from injury for up to 10 days following wounding inflicted via punch biopsy. Results compared to those from injured oral mucosae (GDS5240) and provide insight into the molecular differences in wound healing between the skin and oral mucosa.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 stress, 8 time sets

Platform:

GPL1261

Series:

GSE23006

24 Samples

Download data: CEL

(Submitter supplied) Atopic dermatitis (AD) is a common inflammatory skin disease with a T(H)2 and T22 immune polarity. Despite recent data showing a genetic predisposition to epidermal barrier defects in some patients, a fundamental debate still exists regarding the role of barrier abnormalities versus immune responses in initiating the disease. An extensive study of nonlesional AD (ANL) skin is necessary to explore whether there is an intrinsic predisposition to barrier abnormalities, background immune activation, or both in patients with AD. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4491

Platform:

GPL570

33 Samples

Download data: CEL

Analysis of paired samples of nonlesional atopic dermatitis (ANL) and lesional atopic dermatitis (AL) skin lesions compared with normal skin. ANL skin is characterized by terminal differentiation defects. Results provide insight into molecular mechanisms that characterize ANL skin.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 22 individual, 14 other sets

Platform:

GPL570

Series:

GSE32924

33 Samples

Download data: CEL

(Submitter supplied) To investigate the biological fundtion regualted by Gsdma1/a3 during epidermal barrier formation, we perform acetone/olive oil vs. water treatment on the dorsal skin of control and Gsdma1/Gsdma3 epithelial knowckout (GsdA1A3eKO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 water-treated and 3 aceton/olive oil treated for each genotype (wild type vs. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

10 Samples

Download data: TXT

(Submitter supplied) There is increasing evidence that autophagy contributes to the epidermal differentiation; however, the role of autophagy in epidermal tight junction (TJ) barrier remains unclear. To evaluate the role of autophagy in the maintenance of skin TJ barrier, we knocked out autophagy in human primary keratinocytes by infecting cells with autophagy-related gene 3 (Atg3) C264S mutant adenovirus.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

4 Samples

Download data: CEL, CHP