Conserved Protein Domain Family
CENP-U
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pfam13097: CENP-U (this model, PSSM-Id:315709 is obsolete and has been replaced by 463785)
CENP-A nucleosome associated complex (NAC) subunit
CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 315709
Aligned: 23 rows
Threshold Bit Score: 147.168
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8C4M7       144 RVaSAEGPRSQQRQAAPAA----PSPP--------ERPAEPVTPRRTRLhsAQLSPVDETPA-------TQSQL----KT 200 house mouse
Q4V8G7       143 SV-SIERPRARKPPAAPAAasssSSPS--------ERPAEQVTPRKTSF--PQPSAVEETPA-------AQSQL----KT 200 Norway rat
Q2Z1W2        66 dacgeehSENESSGYVPAPqrtnAERS--------EK-MLLETPEGDVHefSQSGSVREPLMe-----nLNAPN----TT 127 chicken
XP_008248646 145 KVqSPERIGARRCDAVPAGa--pSGLP--------ERRPRSERPEAGGGrgSGAPADGGTPAm------VRSPRgkekET 208 rabbit
XP_001625309 380 SVqNMSDFSESARQHLISDfsqsERPN--------ITSDFSEIASSTVQnsPSNTQDSILISqdssviaDQHER----ST 447 starlet sea ane...
OCA48301     223 RKdKSMAPSKAKYQVQTDAgecsASLD--------EETNSSQTP-----------------Aq-----aKKHRN----KT 268 western clawed ...
XP_002698700 145 KVkPTENISTQ-HEAVSATa--lPGLS--------EKPAEAVTPQKTGPqsAESSAEKATLA-------TEHQL----ET 202 cattle
XP_012429000  66 daygeehsqNEALGHVSAPqgqnTDRQsggkkinfKKSRHSKPSNGDVQkfNTAGAEEELLKe-----tVKTLN----TT 136 zebra finch
ADG04697       1 --cgeersesESISHVSAPqtknTGRS--------KQ-MHLKLSENDVDksNSDDSTDEHLKe-----nMKAPS----TA 60  mallard
XP_003495519 144 KVgSTERASARQHQTAPAAs---PAPH--------VKPVKCVTPERTRChsTQPSVVEETGA-------VKRQL----KT 201 Chinese hamster

Q8C4M7       201 QKKVRPSPGR---RKRPRRGHTDTD--GSESM-----H---IWCLEGKRQ--S--DITELDVILSVFEKTFLEYKQRVES 263 house mouse
Q4V8G7       201 QKKVRPSPGR---RKRPRRGSTHSD--ASESM-----H---ILCLEGKRQ--S--DVMELDVVLSAFERTFLDYKQRVES 263 Norway rat
Q2Z1W2       128 RSEVK----K---KRPSKKSSSDSSvnSPSSV-----Q---LWCPNKLKR--SsrDITELDVVLAEFEKIAANYRQSIES 190 chicken
XP_008248646 209 QKKETMSRGK---RKKTSNEAGGSG--ISDSV-----H---IWCLEGKKK--S--DLMELDIVLSACEKAIQEHKERIES 271 rabbit
XP_001625309 448 QKINQLGNKR---RLQGFKRHHEEK--SADKI-----LvrlYNADQGRKVaiS--DISELDVALTHIERQCLEHREEVES 515 starlet sea ane...
OCA48301     269 SKGAGSPKGKtpeRIQNKSLTPESS--VSGSKnavppK---VWCSEEMPR--SsrDLNELDVVLAEFEDIVEEYRDANDS 341 western clawed ...
XP_002698700 203 Q-KNKMLPGK---RKKPRSYTT--D--TSDCA-----P---VWCLKEKKA--S--DIMELDVFLSAFENILLEYEQKIDS 262 cattle
XP_012429000 137 QFKAK----K---KQSSDENTSDSPvdSPHSV-----Q---IWCPKDLKR--SpqDITELDILLAEVEKIAENYRQSIES 199 zebra finch
ADG04697      61 QLQLK---KK---KQPSEESTPDPSvtSPVSV-----E---VWCPKDLKR--SsrDITELDVVLGEFEKITSNYRQSIES 124 mallard
XP_003495519 202 QKKVRLSPGR---KKKSGSEATDSD--ASERM-----H---IWCLEGKRR--S--SIMELDVILSVFEKTFLEYKQRIES 264 Chinese hamster

Q8C4M7       264 ESCNQAINKFYFKMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQRL 312 house mouse
Q4V8G7       264 ESCNQAISKFYFKIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQRL 312 Norway rat
Q2Z1W2       191 KACRKAVSAFCSAFEDQVTDLITEVQELKNTKKKNAKVVADIKKKRQRL 239 chicken
XP_008248646 272 KICKEAINKFHCNIK-ELIKMLKEAQMLKNLKRKNAKVIADIKKKRQRL 319 rabbit
XP_001625309 516 SFSRQAIKDHFIHIRKELSEAIDQVKEYNKLKYADSEVNRKVEKMKREI 564 starlet sea anemone
OCA48301     342 AACKKAVDMFFNSVKEQITETIEESQKLKNLKRKNTKLQLEIGKKRKEL 390 western clawed frog
XP_002698700 263 RVCKAAINKFHSNLKEELIKMVQEIQMLKTLKRKNAKIISNIEKKRQRL 311 cattle
XP_012429000 200 NICRKAISDFSSAFKDQITDLIAGVQELKNMKKKNAKAITSIKKKRQKL 248 zebra finch
ADG04697     125 GICRKAVNGFCSAFKDQITDLITEVQELKNMKKKNAXVVADIKKKRQRL 173 mallard
XP_003495519 265 EPCSQAVNKFYFKIKGQLIRMLKEVQVLKALKRKNTKIISNMEKKRQRL 313 Chinese hamster
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