Conserved Protein Domain Family
CENP-U
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pfam13097: CENP-U 
CENP-A nucleosome associated complex (NAC) subunit
CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 463785
Aligned: 21 rows
Threshold Bit Score: 161.414
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001625309 374 STAKSTSVQNMSDFSESaRQHLISDfsQSERPNITSDFSEIASSTVQNSPSNTQDSILIsqdssViaDQHERSTQkINQL 453
XP_012429000  68 YGEEHSQNEALGHVSAPqGQNTDRQsgGKKINFKKSRHSKPSNGDVQKFNTAGAEEELL-----KetVKTLNTTQfKAK- 141
XP_005030554  60 LHSTAVDAYGEERSESEsISHVSAPqtKNTGRSKQ-MHLKLSENDVDKSNSDDSTDEHL-----KenMKAPSTAQlQLK- 132
Q2Z1W2        60 LHSTAVDACGEEHSENEsSGYVPAPqrTNAERSEK-MLLETPEGDVHEFSQSGSVREPL-----MenLNAPNTTRsEVK- 132 chicken
XP_003495519 138 EDNVRRKVGSTERASARqHQTAPAA---SPAPHVKPVKCVTPERTRCHSTQPSVVEETG-----A--VKRQLKTQkKVRL 207
Q8C4M7       138 ADDVRRRVASAEGPRSQqRQAAPAA----PSPPERPAEPVTPRRTRLHSAQLSPVDETP-----A--TQSQLKTQkKVRP 206 house mouse
Q4V8G7       137 EDNVRRSV-SIERPRARkPPAAPAAasSSSSPSERPAEQVTPRKTSF--PQPSAVEETP-----A--AQSQLKTQkKVRP 206 Norway rat
XP_849692    142 EAVIRRKVKPAEKIRTRqQEPVPDApcRPSELPEEPAESVTPENIGPLSAKSVVEKGT---------DPSQLKTQ-KKEI 211
EFB30224     111 EGDIRRKVQLAEKIRTRpHEPVPETpcTSLELPEKPAKSVTPKKIGPRGAKSVVAKEMV-----T--EPRQSETQ--KKM 181
XP_012914437 170 EETVRRKVQPAEKIRTQ-----PDTphTSSELPEKPAESVTPKHIRAHSAKSAVEKEPG-----T--EPRHSKTQ--KKV 235

XP_001625309 454 GNKRRLQGFKRHHEe--kSADKIlvrLYNADQGRKVAisDISELDVALTHIERQCLEHREEVESSFSRQAIKDHFIHIRK 531
XP_012429000 142 ---KKQSSDENTSDspvdSPHSV---QIWCPKDLKRSpqDITELDILLAEVEKIAENYRQSIESNICRKAISDFSSAFKD 215
XP_005030554 133 --KKKQPSEESTPDpsvtSPVSV---EVWCPKDLKRSsrDITELDVVLAEFEKITSNYRQSIESGICRKAVNGFCSAFKD 207
Q2Z1W2       133 ---KKRPSKKSSSDssvnSPSSV---QLWCPNKLKRSsrDITELDVVLAEFEKIAANYRQSIESKACRKAVSAFCSAFED 206 chicken
XP_003495519 208 SPGRKKKSGSEATDs--dASERM---HIWCLEGKRRS--SIMELDVILSVFEKTFLEYKQRIESEPCSQAVNKFYFKIKG 280
Q8C4M7       207 SPGRRKRPRRGHTDt--dGSESM---HIWCLEGKRQS--DITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKG 279 house mouse
Q4V8G7       207 SPGRRKRPRRGSTHs--dASESM---HILCLEGKRQS--DVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKG 279 Norway rat
XP_849692    212 FCGKRKKSRSKAVDs--dISDCV---HIWCLKGKKAS--DITELDVVLSAFEKTILEYEQNVESKTCKEAIKEFHSDVKE 284
EFB30224     182 FCGKRKKSRSEATDs--dTSDSV---SIWCLEGKKAS--DITELDVVLSAFEKTILEYKQKVESKICKEAIKKFHSNMKE 254
XP_012914437 236 FCGRKKKSRSEARDs--dRSDCE---PIWCLKGKKAS--DISELDVVLSAFEKTILEYEQKVESKIFKEAIRKFHSNMKE 308

XP_001625309 532 ELSEAIDQVKEYNKLKYADSEVNRKVEKMKREI 564
XP_012429000 216 QITDLIAGVQELKNMKKKNAKAITSIKKKRQKL 248
XP_005030554 208 QITDLITEVQELKNMKKKNAKVVADIKKKRQRL 240
Q2Z1W2       207 QVTDLITEVQELKNTKKKNAKVVADIKKKRQRL 239 chicken
XP_003495519 281 QLIRMLKEVQVLKALKRKNTKIISNMEKKRQRL 313
Q8C4M7       280 ELIRMLKEAQMLKALKMKNTKIIANMEKKRQRL 312 house mouse
Q4V8G7       280 ELIRMLKEVQMLKALKRKNTKIISNMEKKRQRL 312 Norway rat
XP_849692    285 ELLKMLKEFQMSKTLKRNNMKVISDIEKKRQHL 317
EFB30224     255 ELIKMLKEVQVSKTLKRKNTKIISDIEKKRQRL 287
XP_012914437 309 ELIKTLKEVQMSKTLKRKNTKIISDIEKKRQRL 341
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