1OVA


Conserved Protein Domain Family
ovalbumin_like
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cd02059: ovalbumin_like (this model, PSSM-Id:239014 is obsolete and has been replaced by 381015)
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The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory member of SERine Proteinase INhibitorS (serpins). In contrast, SCCA1 inhibits cysteine proteinases such as cathepsin S, K, L, and papain, a so called cross-class serpin.
Links
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Statistics
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PSSM-Id: 239014
Aligned: 7 rows
Threshold Bit Score: 605.953
Created: 14-Dec-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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reactive center
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop
Evidence:
  • Structure:1OVA_A; has a helix in the distal half of the RC loop.
    - View structure with Cn3D
  • Comment:depending on the conformational state, the RC loop is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1OVA_A      4 IGAASMEFCFDVFKELKvhhanENIFYCPIAIMSALAMVYLGAkDSTRTQINKVVRFdklpgfgdsi------------- 70  chicken
P29508      4 LSEANTKFMFDLFQQFRks-keNNIFYSPISITSALGMVLLGAkDNTAQQIKKVLHFdqvtenttgka------------ 70  human
AAH81162    4 LNNSFLEFSLDLYKELKqnpesKNIFFSPLSISSAMGMVLLGArERTAADIEKVLHFpaavsskyskpa----------- 72  African clawed frog
Q96P15      4 LSTANVEFCLDVFKELNsnnigDNIFFSSLSLLYALSMVLLGArGETAEQLEKVLHFshtvdslkpgfk----------- 72  human
Q96P63      4 LVTANTKFCFDLFQEIGkddrhKNIFFSPLSLSAALGMVRLGArSDSAHQIDEVLHFnefsqneskepdpclk------- 76  human
O75635      4 LAAANAEFCFNLFREMDdnqgnGNVFFSSLSLFAALALVRLGAqDDSLSQIDKLLHVntasgygn--------------- 68  human
XP_418985   4 ISRMIIEFCLDLYNKLNrtakgQNIVFSPMSISTSLGLILLGArNNTAAQIEEVLHVshatgttsleselegavpenkse 83  chicken

Feature 1                                                                                     
1OVA_A     71 ---------eaqcgtsvnvHSSLRDILNQItkpndVYSFSLASRLYAEERYPILPEYLQCVKELYrggLEPINFQtaadq 141 chicken
P29508     71 --------atyhvdrsgnvHHQFQKLLTEFnkstdAYELKIANKLFGEKTYLFLQEYLDAIKKFYqtsVESVDFAnapee 142 human
AAH81162   73 --------cqkqtcqtegvHVLFKELFTALnkpneHYELNIANRTYGEKSFTFSKQYLLCLEQLYkakLEPTDFKnnaea 144 African clawed frog
Q96P15     73 --------dspkcsqagriHSEFGVEFSQInqpdsNCTLSIANRLYGTKTMAFHQQYLSCSEKWYqarLQTVDFEqstee 144 human
Q96P63     77 ---snkqkagslnnesglvSCYFGQLLSKLdriktDYTLSIANRLYGEQEFPICQEYLDGVIQFYhttIESVDFQknpek 153 human
O75635     69 -----------ssnsqsglQSQLKRVFSDInashkDYDLSIVNGLFAEKVYGFHKDYIECAEKLYdakVERVDFTnhled 137 human
XP_418985  84 lsqeresspslcntdgnlnHEAFHALLLQLqnlgkDYVLSLANSLFIQQGFEPHQKYLMCSKELYraaLETVDFQralea 163 chicken

Feature 1                                                                                     
1OVA_A    142 ARELINSWVESQTNGIIRNVLQPss------vDSQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTeqesKPVQMMYQI 215 chicken
P29508    143 SRKKINSWVESQTNEKIKNLIPEgn------iGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNkntyKSIQMMRQY 216 human
AAH81162  145 SIVKINAWVECKTKSKIKNLFPKgt------lDDSTVLALVNAVYFKGRWKKQFEKENTKDAPFFLKtndtTTVKMMSQT 218 African clawed frog
Q96P15    145 TRKMINAWVENKTNGKVANLFGKst------iDPSSVMVLVNIIYFKGQRQNKFQVRETVKSPFQLSegknVTVEMMYQI 218 human
Q96P63    154 SRQEINFWVECQSQGKIKELFSKda------iNAETVLVLVNAVYFKAKWETYFDHENTVDAPFCLNanenKSVKMMTQK 227 human
O75635    138 TRRNINKWVENETHGKIKNVIGEgg------iSSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPkcsgKAVAMMHQE 211 human
XP_418985 164 SRLKINDWVESETQGKTEQNCKIkelfapgviDSHTILVLVNVIYFKASWEHKFEEKNTVQRDFKLNqnerKPVQMMYQK 243 chicken

Feature 1                                                                                     
1OVA_A    216 glFRVASMasekMKILELPFAsgtMSMLVLLPDev-----sGLEQLESIINFEKLTEWTssNVMEERKikVYLPRMKMEE 290 chicken
P29508    217 tsFHFASLedvqAKVLEIPYKgkdLSMIVLLPNei-----dGLQKLEEKLTAEKLMEWTslQNMRETRvdLHLPRFKVEE 291 human
AAH81162  219 gkYKLGSHpelkCRILELPYEe-gFSMKIILPDdi-----dGLAELEANLTYEKLTKLMnlENIREVKvvVRLPQFKFGE 292 African clawed frog
Q96P15    219 gtFKLAFVkepqMQVLELPYVnnkLSMIILLPVgi-----aNLKQIEKQLNSGTFHEWTssSNMMEREveVHLPRFKLEI 293 human
Q96P63    228 glYRIGFIeevkAQILEMRYTkgkLSMFVLLPShskd-nlkGLEELERKITYEKMVAWSssENMSEESvvLSFPRFTLED 306 human
O75635    212 rkFNLSVIedpsMKILELRYNg-gINMYVLLPEn-------DLSEIENKLTFQNLMEWTnpRRMTSKYveVFFPQFKIEK 283 human
XP_418985 244 gtFKLGYIeelgTQVLELPYAqklLSMIILLPGetadgspsGLEQTESTMTYENLMLWFssEHMFETVveVYLPRFKLEG 323 chicken

Feature 1                                                      ###########            ######  
1OVA_A    291 KYNLTSVLMaMGITDVFSss-aNLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGvdaas---vseeFRADHPFL 366 chicken
P29508    292 SYDLKDTLRtMGMVDIFNgd-aDLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVgfgssptstneeFHCNHPFL 370 human
AAH81162  293 TYSLKEVLKsMGMTSVFQg--aDLSGISDKVSLVISTVIHKSFIEVNEEGTEAAAATGIGivvtslplppeeFVADHPFL 370 African clawed frog
Q96P15    294 KYELNSLLKpLGVTDLFNqvkaDLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAAATGDSiavksl-pmraqFKANHPFL 372 human
Q96P63    307 SYDLNSILQdMGITDIFDetraDLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVvsersl-rswveFNANHPFL 385 human
O75635    284 NYEMKQYLRaLGLKDIFDeskaDLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNivekql-pqstlFRADHPFL 362 human
XP_418985 324 TFNLNEVLKaMGMTDIFSeskaDLSALSSEKSLVLSNIVHKAYVEVNEEGTTAAAATGATivrrsl-plievFIADRPFL 402 chicken

Feature 1                         
1OVA_A    367 FCIKHiatnAVLFFGRCVSP 386 chicken
P29508    371 FFIRQnktnSILFYGRFSSP 390 human
AAH81162  371 LTIEHnqtkSMLFFGRFTSP 390 African clawed frog
Q96P15    373 FFIRHthtnTILFCGKLASP 392 human
Q96P63    386 FFIRHnktqTILFYGRVCSP 405 human
O75635    363 FVIRKd--dIILFSGKVSCP 380 human
XP_418985 403 FFIRHnptsTILFFGKFCSP 422 chicken

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