1QU3


Conserved Protein Domain Family
Anticodon_Ia_Ile_BEm
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cd07960: Anticodon_Ia_Ile_BEm 
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Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Links
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Statistics
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PSSM-Id: 153414
Aligned: 180 rows
Threshold Bit Score: 127.641
Created: 27-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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anticodontRNA binding
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1QU3: Staphylococcus aureus isoleucyl-tRNA synthetase binds to the anticodon of its cognate tRNA(Ile), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #  #                                                          
1QU3_A        633 ISDEILKQTSD-DYRKIRNTLRFMLGNINDFNpdtdsi----peselLEVDRYLLNRLREFTASTINNYENfDYLNIYQE 707  Staphylococcu...
NP_001123293  687 MKNSLLQGSAD-TVHKLRLVFRFLLGALHTYDenknit----vepqyHYLDKYMLHQLYHYHQEIQSLYEKyQYHNVSKT 761  jewel wasp
XP_001949755  667 VTKETLNDSKQ-SVDKLRLIIRFLLGSLNNVKennfmh----ganhlRYLDKYMMLELISFENETNKLYNTfQYNKVCAK 741  pea aphid
NP_648837     650 VSDKLLQQAAE-NLCKIRGTMRYLKGVIGEKQsgekli----rtsdkSYLNRYLLSQLVEFESEVEKLYQAyEYNRVVAC 724  fruit fly
EEB14393      658 VSDSILKSEFK-TVQSIRLIFRYLLGALNNARskdll-----enddlLTLDKYLLNSCYNFYKSVMHSYNTyKTYSVCSQ 731  human body louse
XP_001654107  585 VSHKLLGSSAE-NLQKIRGIMKYLLGATSEAVdsrid------lsnlTHVDQYFLQQLCLFHDTVFSLYDSyQYNKASAT 657  yellow fever ...
XP_001610095  829 LNNSNISEAVD-LAKKIANFFKYAIGVTHDCKiksdtcr--lrldyfNALDIYMLKLSYDLVYTARKYFKEgCLHKVVRE 905  Babesia bovis...
XP_312846     654 VSHKLLGSSAE-SVQKLRGILKFLLGVVAPSGpeegkplpaivldasQHIDRYFLHELEGFHRQAFELYDSyQHNRATAV 732  Anopheles gam...
XP_970208     643 ISNNVLQASAD-ELHKIRSVIRFSLGCLYDYQhssvd------yknlSLLDKYMLHLLYLFHEQALEAINDyRFQQICKS 715  red flour beetle
XP_952176     973 VNNDTLNSKMDdDIKADWSVISIPDIGISTVKks-----------qlSGMDLYFLSQAYSLAESSSEYYRKgQFFKVLDM 1041 Theileria ann...

Feature 1                                                                                         
1QU3_A        708 VQNFINVELsNFYLDYGKDILyieqrdshirrsMQTVLYQILVDMTKLLAPILVHTAEEVWSHTPHvk------------ 775  Staphylococcu...
NP_001123293  762 VVNFITNDVsAVYCHMIKDRIycekidspyrlgALDVIGEILSITTRSIAPILPHLAEEVWLHHPEnl------------ 829  jewel wasp
XP_001949755  742 LLHFITNQVsGLYVHHIKDRLycdpiesndrlaCTATLQAILETLLKHIAPILPHLAEEAFSYYPLrrnt---------- 811  pea aphid
NP_648837     725 VQNFIANQVsAVYVHLIKDRLycgdd--hellaIRQTLTHCYQQLCKSLWPIVPFLVEESWSYYDTt------------- 789  fruit fly
EEB14393      732 ILHFVPNNVsSRYVSAIKDRLycdsqessrrkaCLYTLNSILYTLSYSLAPILPHLVEEVFLHHPVss------------ 799  human body louse
XP_001654107  658 IVTFCVSTLsGFYVHLVKDRLycgsd--kqfhnLQAILAQTLKVLCKVLWPIAPFLVEESWSYSGRep------------ 723  yellow fever ...
XP_001610095  906 LEIFLTRFS-NIYVSYCKDRLycdvkhgwsrtcAQIIIKKIMRNVLDVVAPIMPHMAEDVYQTIHNvtmpqkr------k 978  Babesia bovis...
XP_312846     733 ILNFCLSTLsGLYLHVIKDRLycgsp--eqhshLRAILDHTYRTLAQVLWPIVPFLVEESWTFYGKyddipqtqqsvcrs 810  Anopheles gam...
XP_970208     716 VINLLTNPVsALYYNGIKDRLycdpldsisrksSQFVLLQIFEIVTQAIGPIVPHFVEEMFLHLPHkn------------ 783  red flour beetle
XP_952176    1042 VEKFITSLS-SVYLSYIKNFLyvykredeknkaIRFVLFKILYILLRVLGPIVPHMCEDIYRSINPe------------- 1107 Theileria ann...

Feature 1                                                  
1QU3_A        776 ----eESVHLADMPKVve---vDQALLDKWRTFMNLRDDVN 809  Staphylococcus aureus
NP_001123293  830 ---asVPIFHTQHRSLes--wnNLEYKEIIEKALDLRSEIN 865  jewel wasp
XP_001949755  812 -tffkSSIMNLNQIVIp----dSEQVILIMENALMVKNKVS 847  pea aphid
NP_648837     790 -----GGAFHEQIVQTnpe-wqDTKATEVINAAFDVKRLIN 824  fruit fly
EEB14393      800 ---enKRVFFRKEPWVprewwsNDTTDKTILLLDNFKKDIV 837  human body louse
XP_001654107  724 ---ffKSSQRLDFTPPp-----VSNVTPIIEQALNLKRHVF 756  yellow fever mosquito
XP_001610095  979 dmaniKSVFGKRWMKMpny-lsKVDVNTAIGTLLDLRNLVN 1018 Babesia bovis T2Bo
XP_312846     811 gddaaASVHAVQCALAlrhavyQQAQLNVNTWLLEVAVECN 851  Anopheles gambiae str. PEST
XP_970208     784 ----gKTYFTSTHSKAetc-wkNDVVDKVMEVILNIKKEIN 819  red flour beetle
XP_952176    1108 ----sISLFRRRWPVRpk---tLTDVTESIGTALTVRKLIN 1141 Theileria annulata strain Ankara

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