1GAX,2BTE,1F7U,2CSX,1QU3,1JZS,1WZ2,1U0B


Conserved Protein Domain Family
Anticodon_Ia_like
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cd07375: Anticodon_Ia_like 
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Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Links
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Statistics
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PSSM-Id: 153408
Aligned: 8 rows
Threshold Bit Score: 69.0715
Created: 4-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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anticodontRNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:anticodon binding site
Evidence:
  • Structure:1GAX: Thermus thermophilus valyl-tRNA synthetase binds to the CAC anticodon of its cognate tRNA(Val), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  ##  ##                                                       
1GAX_B    569 LRWLEMARN-----FANKLYNAARFvllsregfqaked------tptladrfmrsrLSRGVEEITALYEAl-dLAQAARE 636  Thermus thermophilus
2BTE_D    678 EEGVQGAWR-----FLNRIYRRVAEdrealletsgvfqa----ealegkdrelygkLHETLKKVTEDLEAl-rFNTAIAA 747  Thermus thermophilus
1F7U_A    475 WERMLSFEGdtgpyLQYAHSRLRSVernasgitqekwinadfsllkepaakllirlLGQYPDVLRNAIKTh-ePTTVVTY 553  baker's yeast
2CSX_A    340 LNRINGELAn---eIGNLYSRVVNMahkflggevs-----------gardeeyakiAQESIKNYENYMEKv-nFYKAIEE 404  Aquifex aeolicus
1QU3_A    635 DEILKQTSD-----DYRKIRNTLRFmlgnindfnpdtdsi-pesellevdryllnrLREFTASTINNYENf-dYLNIYQE 707  Staphylococcus au...
1JZS_A    632 PNLVRETVRd----YFLTLWNVYSFfvtyanldrpdlknppppekrpemdrwllarMQDLIQRVTEALEAy-dPTTSARA 706  Thermus thermophilus
1WZ2_A    691 RKEVGKLRK-----QIERFYELISQfaeyevkgnve---------lkdidrwmlhrLNKAIKETTNALEEf-rTRTAVQW 755  Pyrococcus horiko...
1U0B_B    306 EENLKQARA-----ALERLYTALRGtdktv----------------------apagGEAFEARFIEAMDDdfnTPEAYSV 358  Escherichia coli

Feature 1                   #                                       
1GAX_B    637 V-YELVWSefcDWYLeaakpalka------gnahtlrtLEEVLAVLLKLLHPMM 683  Thermus thermophilus
2BTE_D    748 L-MEFLNAl--YEYRkdrp---------------vtpvYRTAIRYYLQMLFPFA 783  Thermus thermophilus
1F7U_A    554 L-FKLTHQv--SSCYdvlwvagqte----elatarlalYGAARQVLYNGMRLLG 600  baker's yeast
2CSX_A    405 I-LKFTSYl--NKYVdekqpwalnkerkkeelqkvlyaLVDGLFVLTHLLYPIT 455  Aquifex aeolicus
1QU3_A    708 V-QNFINVelsNFYLdygkdilyieqrdshirrsmqtvLYQILVDMTKLLAPIL 760  Staphylococcus aureus
1JZS_A    707 L-RDFVVEdlsQWYVrrnrrrfwkne-daldreaayatLYEALVLVATLAAPFT 758  Thermus thermophilus
1WZ2_A    756 AfYSIMNDl--RWYLrrtegrd---------deakryvLRTLADVWVRLMAPFT 798  Pyrococcus horikoshii OT3
1U0B_B    359 L-FDMAREv--NRLKaed-----------------maaANAMASHLRKLSAVLG 392  Escherichia coli

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