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Report for CCDS13449.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
13449.2 Public Homo sapiens 20 MC3R 24 110 108 CCDS HistoryNCBI Gene:4159Re-query CCDS DB by CCDS ID:13449.2Re-query CCDS DB by GeneID:4159See the combined annotation on chromosome 20 in Sequence Viewer

Public Note for CCDS 13449.1
The coding region has been updated to shorten the N-terminus based on the presence of a downstream start codon that shows good cross-species conservation, and for consistency with that used by other family members, including the genes encoding the human melanocortin 4 and melanocortin 5 receptors. The use of an alternative upstream start codon, which is specific to primate species, would increase the protein length from 323 aa to 360 aa. This longer protein is referred to in the literature, including PMIDs:15292330 and 8463333. Experimental data in PMIDs:8957262 and 9237634 indicate that deletion of the N-terminus does not affect the function of the protein, but there is no conclusive evidence indicating which start codon is preferentially used in vivo.

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)


Attributes
CDS uses downstream AUG

Sequence IDs included in CCDS 13449.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000243911.2 ENSP00000243911.2 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000243911.2Link to Ensembl Protein Viewer:ENSP00000243911.2Re-query CCDS DB by Nucleotide ID:ENST00000243911Re-query CCDS DB by Protein ID:ENSP00000243911
Original member Current member NCBI NM_019888.3 NP_063941.3 MANE Select Accepted alive Link to Nucleotide Sequence:NM_019888.3Link to Protein Sequence:NP_063941.3Re-query CCDS DB by Nucleotide ID:NM_019888Re-query CCDS DB by Protein ID:NP_063941Link to BLAST:NP_063941.3

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_063941.3 323 P41968 323 100% 0 0

Chromosomal Locations for CCDS 13449.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '+' strand of Chromosome 20 (NC_000020.11)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 20Link to Ensembl Genome Browser on chromosome 20See the combined annotation on chromosome 20 in Sequence Viewer

Chromosome Start Stop Links
20 56248844 56249815 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 20Link to Ensembl Genome Browser on chromosome 20

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (972 nt):
ATGAATGCTTCGTGCTGCCTGCCCTCTGTTCAGCCAACACTGCCTAATGGCTCGGAGCACCTCCAAGCCC
CTTTCTTCAGCAACCAGAGCAGCAGCGCCTTCTGTGAGCAGGTCTTCATCAAGCCCGAGGTTTTCCTGTC
TCTGGGCATCGTCAGTCTGCTGGAAAACATCCTGGTTATCCTGGCCGTGGTCAGGAACGGCAACCTGCAC
TCCCCGATGTACTTCTTTCTCTGCAGCCTGGCGGTGGCCGACATGCTGGTAAGTGTGTCCAATGCCCTGG
AGACCATCATGATCGCCATCGTCCACAGCGACTACCTGACCTTCGAGGACCAGTTTATCCAGCACATGGA
CAACATCTTCGACTCCATGATCTGCATCTCCCTGGTGGCCTCCATCTGCAACCTCCTGGCCATCGCCGTC
GACAGGTACGTCACCATCTTTTACGCGCTCCGCTACCACAGCATCATGACCGTGAGGAAGGCCCTCACCT
TGATCGTGGCCATCTGGGTCTGCTGCGGCGTCTGTGGCGTGGTGTTCATCGTCTACTCGGAGAGCAAAAT
GGTCATTGTGTGCCTCATCACCATGTTCTTCGCCATGATGCTCCTCATGGGCACCCTCTACGTGCACATG
TTCCTCTTTGCGCGGCTGCACGTCAAGCGCATAGCAGCACTGCCACCTGCCGACGGGGTGGCCCCACAGC
AACACTCATGCATGAAGGGGGCAGTCACCATCACCATTCTCCTGGGCGTGTTCATCTTCTGCTGGGCCCC
CTTCTTCCTCCACCTGGTCCTCATCATCACCTGCCCCACCAACCCCTACTGCATCTGCTACACTGCCCAC
TTCAACACCTACCTGGTCCTCATCATGTGCAACTCCGTCATCGACCCACTCATCTACGCTTTCCGGAGCC
TGGAATTGCGCAACACCTTTAGGGAGATTCTCTGTGGCTGCAACGGCATGAACTTGGGATAG

Translation (323 aa):
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLH
SPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAV
DRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHM
FLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAH
FNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG


Links Key
 Links to:   History report
  BLAST report
  Entrez Gene
  Nucleotide report
  Protein report
 Re-query CCDS DB by:   CCDS ID
  Gene ID
  Nucleotide ID
  Protein ID
 Genome Browser Links:   Ensembl Genome Browser
  NCBI Sequence Viewer
  UCSC Genome Browser
  VEGA Genome Browser

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