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History Report on CCDS ID 13449  | Interpretation | Date | Source | Comment | Data |
|---|
| CCDS: Made public |
03/02/2005 |
NCBI |
|
CCDS Release: 1 |
| CCDS: Retained |
02/26/2007 |
NCBI |
|
CCDS Release: 3 |
| CCDS: Retained |
04/30/2008 |
NCBI |
|
CCDS Release: 5 |
| CCDS: Public note |
07/02/2008 |
NCBI |
The coding region has been updated to shorten the N-terminus based on the presence of a downstream start codon that shows good cross-species conservation, and for consistency with that used by other family members, including the genes encoding the human melanocortin 4 and melanocortin 5 receptors. The use of an alternative upstream start codon, which is specific to primate species, would increase the protein length from 323 aa to 360 aa. This longer protein is referred to in the literature, including PMIDs:15292330 and 8463333. Experimental data in PMIDs:8957262 and 9237634 indicate that deletion of the N-terminus does not affect the function of the protein, but there is no conclusive evidence indicating which start codon is preferentially used in vivo. |
CCDS version: 13449.1 |
| CCDS: Updated |
07/28/2009 |
NCBI |
|
CCDS Release: 6 |
| CCDS: Retained |
03/30/2011 |
NCBI |
|
CCDS Release: 8 |
| CCDS: Retained |
08/11/2011 |
NCBI |
|
CCDS Release: 9 |
| CCDS: Retained |
09/19/2012 |
NCBI |
|
CCDS Release: 11 |
| CCDS: Retained |
03/21/2013 |
NCBI |
|
CCDS Release: 12 |
| CCDS: Retained |
08/30/2013 |
NCBI |
|
CCDS Release: 14 |
| CCDS: Retained |
11/21/2013 |
NCBI |
|
CCDS Release: 15 |
| CCDS: Retained |
06/20/2014 |
NCBI |
|
CCDS Release: 17 |
| CCDS: Retained |
04/03/2015 |
NCBI |
|
CCDS Release: 18 |
| CCDS: Retained |
08/11/2016 |
NCBI |
|
CCDS Release: 20 |
| CCDS: Review status |
10/03/2016 |
NCBI |
|
by RefSeq, Havana and CCDS collaboration |
| CCDS: Retained |
05/16/2018 |
NCBI |
|
CCDS Release: 22 |
| CCDS: Retained |
08/10/2022 |
NCBI |
|
CCDS Release: 24 |
|
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