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    Wdr73 WD repeat domain 73 [ Mus musculus (house mouse) ]

    Gene ID: 71968, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Wdr73provided by MGI
    Official Full Name
    WD repeat domain 73provided by MGI
    Primary source
    MGI:MGI:1919218
    See related
    Ensembl:ENSMUSG00000025722 AllianceGenome:MGI:1919218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200011I23Rik; 2410008B13Rik
    Summary
    Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to colocalize with cleavage furrow; cytosol; and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.9), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D3; 7 45.71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80540471..80551017, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80890723..80901269, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene predicted gene, 51451 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028026.2 → NP_082302.2  WD repeat-containing protein 73

      See identical proteins and their annotated locations for NP_082302.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK010448, AK169377, AK169527, BM940898
      Consensus CDS
      CCDS52282.1
      UniProtKB/Swiss-Prot
      Q05C70, Q3TEN7, Q571I2, Q8BSB9, Q8CF62, Q9CWR1
      Related
      ENSMUSP00000026816.9, ENSMUST00000026816.15
      Conserved Domains (3) summary
      COG2319
      Location:238 → 364
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:279 → 322
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:238 → 364
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_027976.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744, AK169377, BC068122
      Related
      ENSMUST00000139990.8

    2. NR_152100.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences at the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744

    3. NR_152101.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123744

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80540471..80551017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153449.1 → XP_036009342.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170 → 213
      7WD40; WD40 repeat [structural motif]

    2. XM_036153447.1 → XP_036009340.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170 → 213
      7WD40; WD40 repeat [structural motif]

    3. XM_036153448.1 → XP_036009341.1  WD repeat-containing protein 73 isoform X1

      Conserved Domains (2) summary
      COG2319
      Location:129 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170 → 213
      7WD40; WD40 repeat [structural motif]

    4. XM_006541206.1 → XP_006541269.1  WD repeat-containing protein 73 isoform X1

      See identical proteins and their annotated locations for XP_006541269.1

      UniProtKB/Swiss-Prot
      Q9CWR1
      Conserved Domains (2) summary
      COG2319
      Location:129 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170 → 213
      7WD40; WD40 repeat [structural motif]

    5. XM_006541209.1 → XP_006541272.1  WD repeat-containing protein 73 isoform X1

      See identical proteins and their annotated locations for XP_006541272.1

      UniProtKB/Swiss-Prot
      Q9CWR1
      Conserved Domains (2) summary
      COG2319
      Location:129 → 255
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:170 → 213
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWR1.1 GenPept UniProtKB/Swiss-Prot:Q9CWR1

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