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    Hmcn2 hemicentin 2 [ Mus musculus (house mouse) ]

    Gene ID: 665700, updated on 4-May-2024

    Summary

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    Official Symbol
    Hmcn2provided by MGI
    Official Full Name
    hemicentin 2provided by MGI
    Primary source
    MGI:MGI:2677838
    See related
    Ensembl:ENSMUSG00000055632 AllianceGenome:MGI:2677838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030068H01
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Located in several cellular components, including basement membrane; cell cortex; and extracellular region. Is expressed in early embryo; gut; lung; and reproductive system. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 30.0), duodenum adult (RPKM 18.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 21.81 cM
    Exon count:
    99
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31204273..31350751)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31314255..31460738)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 107 Neighboring gene predicted gene, 22516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31112123-31112306 Neighboring gene neuronal calcium sensor 1 Neighboring gene STARR-seq mESC enhancer starr_04149 Neighboring gene STARR-positive B cell enhancer ABC_E504 Neighboring gene argininosuccinate synthetase 1 Neighboring gene predicted gene, 32952 Neighboring gene predicted gene 13426

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31312, MGC49669

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hemicentin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370902.1 → NP_001357831.1  hemicentin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732564, AL732572, AL928861
      UniProtKB/Swiss-Prot
      A2AJ76, Q8BNH3
      Related
      ENSMUSP00000109160.3, ENSMUST00000113532.9
      Conserved Domains (12) summary
      smart00408
      Location:4242 → 4304
      IGc2; Immunoglobulin C-2 Type
      smart00179
      Location:4879 → 4918
      EGF_CA; Calcium-binding EGF-like domain
      smart00409
      Location:793 → 876
      IG; Immunoglobulin
      smart00410
      Location:707 → 783
      IG_like; Immunoglobulin like
      cd00198
      Location:38 → 196
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam07645
      Location:4684 → 4727
      EGF_CA; Calcium-binding EGF domain
      cd00096
      Location:3239 → 3303
      Ig; Immunoglobulin domain
      pfam07474
      Location:4406 → 4588
      G2F; G2F domain
      pfam07679
      Location:4318 → 4404
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1981 → 2056
      Ig_3; Immunoglobulin domain
      pfam14670
      Location:4647 → 4682
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl11960
      Location:1262 → 1336
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31204273..31350751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498503.5 → XP_006498566.1  hemicentin-2 isoform X2

      UniProtKB/Swiss-Prot
      A2AJ76, Q8BNH3
      Conserved Domains (12) summary
      smart00408
      Location:4259 → 4321
      IGc2; Immunoglobulin C-2 Type
      smart00179
      Location:4789 → 4829
      EGF_CA; Calcium-binding EGF-like domain
      smart00409
      Location:1553 → 1633
      IG; Immunoglobulin
      smart00410
      Location:793 → 876
      IG_like; Immunoglobulin like
      cd00198
      Location:38 → 196
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam07645
      Location:4701 → 4744
      EGF_CA; Calcium-binding EGF domain
      cd00096
      Location:3256 → 3320
      Ig; Immunoglobulin domain
      pfam07474
      Location:4423 → 4605
      G2F; G2F domain
      pfam07679
      Location:4335 → 4421
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1998 → 2073
      Ig_3; Immunoglobulin domain
      pfam14670
      Location:4664 → 4699
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl11960
      Location:1262 → 1336
      Ig; Immunoglobulin domain

    2. XM_006498501.5 → XP_006498564.1  hemicentin-2 isoform X1

      UniProtKB/Swiss-Prot
      A2AJ76, Q8BNH3
      Conserved Domains (12) summary
      smart00408
      Location:4259 → 4321
      IGc2; Immunoglobulin C-2 Type
      smart00179
      Location:4896 → 4935
      EGF_CA; Calcium-binding EGF-like domain
      smart00409
      Location:707 → 783
      IG; Immunoglobulin
      smart00410
      Location:793 → 876
      IG_like; Immunoglobulin like
      cd00198
      Location:38 → 196
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam07645
      Location:4701 → 4744
      EGF_CA; Calcium-binding EGF domain
      cd00096
      Location:3256 → 3320
      Ig; Immunoglobulin domain
      pfam07474
      Location:4423 → 4605
      G2F; G2F domain
      pfam07679
      Location:4335 → 4421
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1998 → 2073
      Ig_3; Immunoglobulin domain
      pfam14670
      Location:4664 → 4699
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl11960
      Location:1262 → 1336
      Ig; Immunoglobulin domain

    3. XM_006498504.2 → XP_006498567.1  hemicentin-2 isoform X3

      UniProtKB/Swiss-Prot
      A2AJ76, Q8BNH3
      Conserved Domains (11) summary
      smart00408
      Location:4104 → 4166
      IGc2; Immunoglobulin C-2 Type
      smart00179
      Location:4741 → 4780
      EGF_CA; Calcium-binding EGF-like domain
      smart00409
      Location:638 → 721
      IG; Immunoglobulin
      smart00410
      Location:552 → 628
      IG_like; Immunoglobulin like
      pfam07645
      Location:4546 → 4589
      EGF_CA; Calcium-binding EGF domain
      cd00096
      Location:3101 → 3165
      Ig; Immunoglobulin domain
      pfam07474
      Location:4268 → 4450
      G2F; G2F domain
      pfam07679
      Location:4180 → 4266
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1843 → 1918
      Ig_3; Immunoglobulin domain
      pfam14670
      Location:4509 → 4544
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl11960
      Location:1107 → 1181
      Ig; Immunoglobulin domain

    RNA

    1. XR_003953689.2 RNA Sequence

      Related
      ENSMUST00000226996.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177649.5: Suppressed sequence

      Description
      NM_177649.5: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJ76.1 GenPept UniProtKB/Swiss-Prot:A2AJ76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials