1GL4


Conserved Protein Domain Family
G2F
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pfam07474: G2F (this model, PSSM-Id:369383 is obsolete and has been replaced by 462175)
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G2F domain
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.
Links
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Statistics
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PSSM-Id: 369383
Aligned: 76 rows
Threshold Bit Score: 194.673
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1GL4_A         47 GSPQRVNGKVKGRIfvgssqVPVVFENTDLHSYVV----MNHGRSYTA----I----STIPETVGYSLLPLAPIGGIIGW 114  house mouse
XP_001920501 3454 eSPRRARGSLIGMV------NEKEFGVAYLEANIT----ENDLEGTST----LeahvENIPPSVGPLLRVLVSVFAPVYW 3519 zebrafish
A2AJ76       4431 GEPRGSRGSMTGVI------NGQEFGMATLNISVL----QQGSSEAPT----IwssiSQVPASVGPLMRVLVVTIAPIYW 4496 house mouse
EKC40013     3257 rlpgKAFGTLVGYI------NGVDLTESTINAVMT----TTDDGQNIK----VaatiKDLPPNVGRHVEHLVSVLSPVYW 3322 Pacific oyster
XP_014351769 4083 GFPLRARGSLIGVI------NDKEFGVAFLNTNIT----ENTDAGYTTvqgnI----ENIPETVGPLMKVLVSVFAPIYW 4148 coelacanth
XP_015222023 2895 aVPQRARGSLIGMV------NDREFGVAYLDANVTarpeDSGSRLQAR----V----GNLPGAVGPLLRVLVSVFAPIYW 2960 spotted gar
XP_018668081 4896 GGPREGEGIAFGTI------NDIPFGASGISANGT----DIGGDKTRI----Vae-lDNIPPSIGSALKSQVSILSPIAW 4960 vase tunicate
XP_023350063 3742 GEPRGSRGSMVGVI------NGQEFGVASLNTSVL----QEIEDGATT----IqssiNNIPPDVGPLMRILVVAIAPIYW 3807 Tasmanian devil
XP_012914255 4280 GEPRGSRGSMSGVI------NGQEFSRAILNTSMR----KEAGSGATT----IhssiSHVPASVGPLMRALVVTIAPIYW 4345 domestic ferret
XP_026199076 3449 eaPRKTRGSLIGMV------NDREFGVSFLEANIT----DNVEEGSST----LqahlDNIPPSIGPLLRVLVSVFTPIYW 3514 climbing perch

1GL4_A        115 MFAVEQDGFKNGFSITGGEFTRQAEVTFLgHPGKLVLKQQFSGIDEHGHLTISTELEGRVPQIPYGASVHIEPYTELYHY 194  house mouse
XP_001920501 3520 TTVYQTQETQNGFSITEGQFRQESQLEFE-TGEILKLTHVARGLDGEGVLLVDIVINGFVPPMLLSSNLNLQEFDESYVQ 3598 zebrafish
A2AJ76       4497 ALARESGEALNGYSLTGGSFQQESQMEFS-TGELLTMTQVARGLDPDGLLLVDMKINGMIPESLADGDLRVQDFQEHYVQ 4575 house mouse
EKC40013     3323 VTASERGGAKNGLSLTDGKFSRDVQVEYA-TGEIVRMSQYANGVDEDGVLQIDVIIRGVVPDLSQGAELTLTPYYENYIQ 3401 Pacific oyster
XP_014351769 4149 SVAYEKRDTINGFSLTRGVFRQESQVEFA-TGEILRITQVARGLDADGVLLFDIVISGFMPKLLANSDVKVKDFSENYVQ 4227 coelacanth
XP_015222023 2961 TTVLQAGESRNGFALTRGVFRQESQVEFE-TGEVLRLTHVARGLDAEGVLLVDIVINGFVPRALAGAQLTLQGFRESYVQ 3039 spotted gar
XP_018668081 4961 VMAKEIKGAYNGYSLTSGVFNRVVMVEFA-SGDTVKMTHHVHGVNARGKLQMDVSLEGTVPQTSPNTDIQIKDYTEDYLQ 5039 vase tunicate
XP_023350063 3808 VLAGQSGEALNGYSLTRGNFRQESQVEFA-TGELLHLTQVARGLDRDGLLLLDVVVNGFIPEVLPTAHLQVQDFRERYVQ 3886 Tasmanian devil
XP_012914255 4346 ALAGESGDALNGHSLTGGSFLQKSHVEFA-TGELLTMTQEAWGLDPDGLLLLDVEVSGGIPESLAEAELQVQDFEESYVQ 4424 domestic ferret
XP_026199076 3515 TTVLQNGAARNGYSFTQGQFRQESQVEFE-TGEILRLTHVARGLDSEGVLLIDIVINGFVPPSLTSSHLNLQEFDESYVQ 3593 climbing perch

1GL4_A        195 SSSvI-TSSSTREYTVMEPDQDgaapshthIYQWRQTITFQECAHDD 240  house mouse
XP_001920501 3599 TGSgQlYSWSTQNHIRDGAPLT---------LRCNHTMVFEGPESRq 3636 zebrafish
A2AJ76       4576 TGPgQlFAGSTQRFLHDSLPAS---------LRCNHSIQYDETRGLQ 4613 house mouse
EKC40013     3402 TGQgNiFARSSRTIRMDGHLLP---------YSWNHSISYETTEimp 3439 Pacific oyster
XP_014351769 4228 TGPgQlYAWSTQRLRQEDSWMP---------FHCNHTVEYEASLGRQ 4265 coelacanth
XP_015222023 3040 TGPgQlYAWSSQRPLVNGAPV---------SLRCNHSVIYEAggarq 3077 spotted gar
XP_018668081 5040 TGAgSlYAFSDRLMVMDGFILP---------YTWNHTITYNSSRGLM 5077 vase tunicate
XP_023350063 3887 IGPgElYVGSTQTFLKDGAPTD---------FHCNHTIKYDSALGpq 3924 Tasmanian devil
XP_012914255 4425 TGPgHlFVGSTQHFLRDGLPTF---------LRCNHSVQYKAAQglq 4462 domestic ferret
XP_026199076 3594 TGQgQlYSWSSQTHQRGGNPMV---------LRCNHTIIYEGQEERQ 3631 climbing perch
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