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    ZNF385C zinc finger protein 385C [ Homo sapiens (human) ]

    Gene ID: 201181, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF385Cprovided by HGNC
    Official Full Name
    zinc finger protein 385Cprovided by HGNC
    Primary source
    HGNC:HGNC:33722
    See related
    Ensembl:ENSG00000187595 AllianceGenome:HGNC:33722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta (RPKM 4.2), testis (RPKM 3.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q21.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42025576..42098473, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42882106..42954978, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40177594..40250491, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40085993-40086896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40091696-40092276 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:40102816-40102967 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40110957-40111564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40111565-40112170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112171-40112776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112777-40113382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40119287-40119844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40119845-40120402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40120403-40120960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40139962-40140462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40140463-40140963 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:40162959-40163488 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40180775-40181563 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene chromosome 17 open reading frame 113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40203397-40203898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40214064-40214654 Neighboring gene Sharpr-MPRA regulatory region 8946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8513 Neighboring gene Sharpr-MPRA regulatory region 13373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40220039-40220539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40223445-40224418 Neighboring gene Sharpr-MPRA regulatory region 2167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40256421-40257354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40257355-40258286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40259930-40260442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40267799-40268334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8516 Neighboring gene DExH-box helicase 58 Neighboring gene lysine acetyltransferase 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
    2. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
    3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 385C
    Names
    CTD-2132N18.2
    CTD-2132N18.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378270.1 → NP_001365199.1  zinc finger protein 385C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Conserved Domains (3) summary
      smart00451
      Location:45 → 74
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:303 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:370 → 394
      zf-met; Zinc-finger of C2H2 type

    2. NM_001392013.1 → NP_001378942.1  zinc finger protein 385C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC105024
      Consensus CDS
      CCDS92306.1
      UniProtKB/TrEMBL
      A0A8I5KWL9, C9J6X6
      Related
      ENSP00000509658.1, ENST00000692273.1
      Conserved Domains (3) summary
      smart00451
      Location:45 → 74
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:304 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:371 → 395
      zf-met; Zinc-finger of C2H2 type

    3. NM_001392014.1 → NP_001378943.1  zinc finger protein 385C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Conserved Domains (3) summary
      smart00451
      Location:45 → 74
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:302 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:369 → 393
      zf-met; Zinc-finger of C2H2 type

    4. NM_001392015.1 → NP_001378944.1  zinc finger protein 385C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Conserved Domains (3) summary
      smart00451
      Location:45 → 74
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:304 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:371 → 395
      zf-met; Zinc-finger of C2H2 type

    5. NM_001392016.1 → NP_001378945.1  zinc finger protein 385C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Conserved Domains (3) summary
      smart00451
      Location:45 → 74
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:304 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:371 → 395
      zf-met; Zinc-finger of C2H2 type

    6. NM_001392017.1 → NP_001378946.1  zinc finger protein 385C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Conserved Domains (2) summary
      sd00020
      Location:230 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:297 → 321
      zf-met; Zinc-finger of C2H2 type

    7. NM_001392018.1 → NP_001378947.1  zinc finger protein 385C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/Swiss-Prot
      A0A087WX54, Q4G0J1, Q66K41
      Related
      ENSP00000497755.1, ENST00000649819.1
      Conserved Domains (2) summary
      sd00020
      Location:225 → 293
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:292 → 316
      zf-met; Zinc-finger of C2H2 type

    8. NM_001393562.1 → NP_001380491.1  zinc finger protein 385C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC105024
      UniProtKB/TrEMBL
      C9J6X6
      Related
      ENSP00000411514.4, ENST00000436535.5
      Conserved Domains (2) summary
      smart00451
      Location:160 → 187
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:305 → 373
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42025576..42098473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42882106..42954978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013624.2: Suppressed sequence

      Description
      NM_001013624.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_001242704.1: Suppressed sequence

      Description
      NM_001242704.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66K41.4 GenPept UniProtKB/Swiss-Prot:Q66K41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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