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Conserved domains on  [gi|1969806714|ref|NP_001378945|]
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zinc finger protein 385C isoform 4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10648587)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Just another zinc finger protein (JAZ or ZNF346), which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 371-395 3.88e-06

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


:

Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 43.25  E-value: 3.88e-06
                          10        20
                  ....*....|....*....|....*
gi 1969806714 371 FHCALCQLQVNSETQLKQHMSSRRH 395
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 160-182 1.75e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


:

Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 41.33  E-value: 1.75e-05
                          10        20
                  ....*....|....*....|...
gi 1969806714 160 CNICHLRFNSANQAEAHYKGHKH 182
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 302-326 5.51e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


:

Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.17  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*
gi 1969806714 302 LYCPTCKVTVNSASQLQAHNTGAKH 326
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 45-74 2.57e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1969806714   45 CDVCNIQLNSAAQAQVHCGGRAHQRRLRQL 74
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 371-395 3.88e-06

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 43.25  E-value: 3.88e-06
                          10        20
                  ....*....|....*....|....*
gi 1969806714 371 FHCALCQLQVNSETQLKQHMSSRRH 395
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 160-182 1.75e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 41.33  E-value: 1.75e-05
                          10        20
                  ....*....|....*....|...
gi 1969806714 160 CNICHLRFNSANQAEAHYKGHKH 182
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 302-326 5.51e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.17  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*
gi 1969806714 302 LYCPTCKVTVNSASQLQAHNTGAKH 326
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 160-187 2.11e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 2.11e-04
                           10        20
                   ....*....|....*....|....*...
gi 1969806714  160 CNICHLRFNSANQAEAHYKGHKHARKLK 187
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNVK 33
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 368-400 1.67e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1969806714  368 SPAFHCALCQLQVNSETQLKQHMSSRRHKDRLA 400
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVK 33
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 45-74 2.57e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1969806714   45 CDVCNIQLNSAAQAQVHCGGRAHQRRLRQL 74
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 45-67 9.61e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 33.62  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|...
gi 1969806714  45 CDVCNIQLNSAAQAQVHCGGRAH 67
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 299-327 9.63e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 33.77  E-value: 9.63e-03
                           10        20
                   ....*....|....*....|....*....
gi 1969806714  299 KGHLYCPTCKVTVNSASQLQAHNTGAKHR 327
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHK 29
 
Name Accession Description Interval E-value
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 371-395 3.88e-06

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 43.25  E-value: 3.88e-06
                          10        20
                  ....*....|....*....|....*
gi 1969806714 371 FHCALCQLQVNSETQLKQHMSSRRH 395
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 160-182 1.75e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 41.33  E-value: 1.75e-05
                          10        20
                  ....*....|....*....|...
gi 1969806714 160 CNICHLRFNSANQAEAHYKGHKH 182
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 302-326 5.51e-05

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 40.17  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*
gi 1969806714 302 LYCPTCKVTVNSASQLQAHNTGAKH 326
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 160-187 2.11e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 2.11e-04
                           10        20
                   ....*....|....*....|....*...
gi 1969806714  160 CNICHLRFNSANQAEAHYKGHKHARKLK 187
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNVK 33
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 371-396 1.10e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 36.38  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1969806714 371 FHCALCQLQVNSETQLKQHMSSRRHK 396
Cdd:pfam12171   2 FYCVLCDKYFKSENALQNHLKSKKHK 27
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 301-327 1.37e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 35.99  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*..
gi 1969806714 301 HLYCPTCKVTVNSASQLQAHNTGAKHR 327
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 368-400 1.67e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.08  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1969806714  368 SPAFHCALCQLQVNSETQLKQHMSSRRHKDRLA 400
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVK 33
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 45-74 2.57e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1969806714   45 CDVCNIQLNSAAQAQVHCGGRAHQRRLRQL 74
Cdd:smart00451   6 CKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 160-182 4.19e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 34.84  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|...
gi 1969806714 160 CNICHLRFNSANQAEAHYKGHKH 182
Cdd:pfam12171   4 CVLCDKYFKSENALQNHLKSKKH 26
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 45-67 9.61e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 33.62  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|...
gi 1969806714  45 CDVCNIQLNSAAQAQVHCGGRAH 67
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 299-327 9.63e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 33.77  E-value: 9.63e-03
                           10        20
                   ....*....|....*....|....*....
gi 1969806714  299 KGHLYCPTCKVTVNSASQLQAHNTGAKHR 327
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHK 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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