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| Status |
Public on Sep 08, 2007 |
| Title |
Expression profiling of the developing and mature Nrl -/- mouse retina (Yoshida et al. 2004, HMG) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a concomitant increase in cones is observed.
Using mouse GeneChips (Affymetrix), we have generated expression profiles of the wild-type and Nrl-/- retina at three time-points representing distinct stages of photoreceptor differentiation.
Keywords: time course
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| Overall design |
Both the Nrl-/- mice and wild type controls were of a matched mixed genetic background (R1 and C57BL/6 strains).
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| Contributor(s) |
Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A |
| Citation(s) |
15163632 |
| Submission date |
Sep 06, 2007 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Swaroop Anand |
| E-mail(s) |
swaroop@umich.edu
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| Phone |
734-615 2246
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| URL |
http://www.umich.edu/~retina
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| Organization name |
University of Michigan
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| Department |
Ophthalmology & Visual Sciences
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| Street address |
1000 Wall St.
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| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48105 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA102425 |
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