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Series GSE7955 Query DataSets for GSE7955
Status Public on Oct 15, 2007
Title Transcriptional response of rat cerebrocortical tissue following acute exposure to permethrin or deltamethrin.
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Pyrethroids are neurotoxicants that disrupt nervous system function by interacting with a variety of membrane bound ion channels on neuronal plasma membranes. This study is designed to investigate the transcriptional events downstream of pyrethroid-induced disruption of nervous system excitability. Adult, male Long-Evans rats were orally dosed in vivo with a single dose of either permethrin (1, 10, or 100 mg/kg) or deltamethrin (0.3, 1, 3 mg/kg) at levels that produce only modest behaviroal effects in the whole animal (Wolansky et al. 2006). Transcriptional profiles were obtained from frontal cerebrocortical tissue 6 hours after acute exposure. The primary goals were 1) to identify dose-responsive biomarkers of effect for pyrethroids and 2) identify sensitive intracellular signaling or metabolic pathways sensitive to pyrethroid compounds.
Keywords: dose response
 
Overall design In total 60 samples were analyzed in the present study: vehicle control (n = 12), 1 mg/kg permethrin (n=8), 10 mg/kg permethrin (n = 8), 100 mg/kg permethrin (n = 8), 0.3 mg/kg deltamethrin (n = 8), 1 mg/kg deltamethrin (n = 8), 3 mg/kg deltamethrin (n = 8). Transcriptional profiles for each test subject were obtained independently, without sample pooling.

The publication will include an Appendix Table comparing the variability of RMA values (see Sample VALUE columns) to that of GCOS values (see Sample .CHP files).
 
Contributor(s) Harrill JA, Li Z, Wright FA, Crofton KM
Citation(s) 19017407
Submission date May 30, 2007
Last update date Jul 31, 2017
Contact name Joshua A Harrill
E-mail(s) harrill.josh@epa.gov
Phone 919-541-4606
Organization name University of North Carolina
Department Curriculum in Toxicology
Lab NBTB/NTD/NHEERL/ORD/USEPA
Street address 109 TW Alexander Drive
City Research Triangle Park
State/province NC
ZIP/Postal code 27711
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (60)
GSM190915 Frontal_Cerebrocortex_Vehicle_6hr_rep1
GSM195231 Frontal_Cerebrocortex_Vehicle_6hr_rep2
GSM195232 Frontal_Cerebrocortex_Vehicle_6hr_rep3
Relations
BioProject PRJNA100699

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7955_RAW.tar 260.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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