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Series GSE5285 Query DataSets for GSE5285
Status Public on Jul 01, 2007
Title Hypertensive Rat Kidney Study: Gender-Selective Responses to Salt in Dahl-Iwai & Sprague-Dawley Rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Dahl-Iwai (DI) salt-sensitive rats were studied using microarrays to identify gender-specific differences in the kidney, both basal differences and responses to a high salt diet. In DI rat kidneys, gene expression profiles demonstrated inflammatory and fibrotic responses selectively in females. Gonadectomy of DI rats abrogated gender differences in gene expression. Gonadectomized female and gonadectomized male DI rats both responded to high salt with the same spectrum of gene expression changes as intact female DI rats. Androgens dominated the gender selective responses to salt. Several androgen-responsive genes were identified with roles potentiating the differential responses to salt including increased male expression of Angiotensin-Vasopressin Receptor and Prolactin Receptor, decreased 5-alpha reductase, and mixed increases and decreases in expression of Cyp4a- genes that can produce eicosanoid hormones. These gender differences potentiate sodium retention by males, and increase kidney function during gestation by females.
Keywords: Disease-State Analysis (Salt-Sensitive Hypertension)
 
Overall design - 68 samples/rats/data tables are represented.
- One microarray was used for each sample.
- 3 rat
 
Contributor(s) Gerhold D, Holder D, Alonso-Galicia M, Figueroa D, Austin C, Bagchi A, Lu M, Connolly B, Keenan K, Jin H, Wang Y
Citation(s) 17481853
Submission date Jul 10, 2006
Last update date Feb 21, 2017
Contact name David Lee Gerhold
Organization name Merck & Co.
Department Mol Invest Toxicol
Lab WP45-304
Street address Broad St & Sumneytown Pk
City West Point
State/province PA
ZIP/Postal code 19486
Country USA
 
Platforms (1)
GPL85 [RG_U34A] Affymetrix Rat Genome U34 Array
Samples (68)
GSM113467 Dahl-Iwai Female LowSalt Cortex rat103 dahl_cortexr_k_103c_072001
GSM113534 Dahl-Iwai Female LowSalt Cortex rat104 dahl_cortexr_k_104c_072001
GSM118328 Dahl-Iwai Female LowSalt Cortex rat105 dahl_cortexr_k_105c_072001
Relations
BioProject PRJNA96395

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Supplementary data files not provided
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