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| Status |
Public on Jul 18, 2013 |
| Title |
Gene expression profiles from peripheral blood mononuclear cells (PBMCs) of osteoarthritis patients and healthy controls |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
By performing a comprehensive exploration of peripheral blood by microarray analysis from a subset of the Genetics osteoARthritis and Progression (GARP) study in comparison with sex and age-matched healthy controls we have identified disease specific gene expression networks. Our data hint at the relevance of apoptosis as an etiological factor in osteoarthritis onset, thereby qualifying expression profiling of blood as a useful tool to understand the underlying molecular mechanisms of osteoarthritis.
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| Overall design |
Case-control study comparing gene expression profiles generated with total messenger RNA obtained from peripheral blood mononuclear cells of controls with that of osteoarthritis (OA) patients from the GARP study.
The GARP study consists in Dutch Caucasian sib pairs with symptomatic OA at multiple joint locations and has been described previously by Riyazi et al (Ann Rheum Dis 2005;64:438-43).
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| Contributor(s) |
Ramos YF, Bos SD, Lakenberg N, Böhringer S, den Hollander WJ, Kloppenburg M, Slagboom E, Meulenbelt I |
| Citation(s) |
23864235 |
| Submission date |
Jul 05, 2013 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Yolande F. M. Ramos |
| E-mail(s) |
y.f.m.ramos@lumc.nl
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| Organization name |
Leiden University Medical Center
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| Department |
Molecular Epidemiology
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| Street address |
Einthovenweg 20
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| City |
Leiden |
| ZIP/Postal code |
2333 ZC |
| Country |
Netherlands |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (139)
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| Relations |
| BioProject |
PRJNA210819 |
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