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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 11, 2011 |
| Title |
Expression data from human bone marrow hematopoietic stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem cell (HSC) population during aging contribute significantly to the manifestation of these age-associated hematopoietic pathologies. While the mouse HSC population has been shown to change both quantitatively and functionally with age, changes in the human HSC and progenitor cell populations during aging have not yet been characterized.
Gene expression profiling revealed that aged human HSC transcriptionally up-regulate genes associated with cell cycle, myeloid lineage specification, and myeloid malignancies. These age-associated alterations in the frequency, function, and gene expression profile of human HSC are significantly similar to those changes observed in mouse HSC, suggesting that hematopoietic aging is an evolutionarily conserved process.
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| Overall design |
In order to elucidate the properties of an aged human hematopoietic system that may predispose to age-associated hematopoietic dysfunction, we evaluated HSC and other hematopoietic progenitor populations from healthy, hematologically normal young and elderly human bone marrow samples. We found that aged human HSC increase in frequency, are less quiescent, and exhibit myeloid-biased differentiation potential compared to young HSC.
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| Contributor(s) |
Pang WW, Price EA, Sahoo D, Beerman I, Maloney WJ, Rossi DJ, Schrier SL, Weissman IL |
| Citation(s) |
22123971 |
| Submission date |
Oct 10, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Debashis Sahoo |
| E-mail(s) |
sahoo@stanford.edu
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| Phone |
650-862-4736
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| Fax |
(650) 736-2961
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| URL |
http://www.stanford.edu/~sahoo
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| Organization name |
Stanford University
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| Department |
Pathology
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| Lab |
Weissman lab
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| Street address |
265 Campus Drive, Rm G3101B
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (27)
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| Relations |
| BioProject |
PRJNA146789 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32719_RAW.tar |
124.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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