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| Status |
Public on Feb 01, 2006 |
| Title |
Analysis of RPE65 loss of function in mouse retina |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To characterize gene response in RPE65-/- mouse model of Leber’s congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age.
Keywords: knock out response over time
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| Overall design |
We compared gene expression in wild type and RPE65-/- retinae at 2, 4 and 6 months of age. Three biological replicates were performed for each of the six conditions analyzed; this series hence contains 18 samples.
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| Contributor(s) |
Michaut L, Cottet S, Gehring WJ, Schorderet D |
| Citation(s) |
17012256 |
| Submission date |
Sep 05, 2005 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Lydia Michaut |
| E-mail(s) |
Lydia.Michaut@unibas.ch
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| Organization name |
Biozentrum, Basel University
|
| Street address |
Klingelbergstrasse 70
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| City |
Basel |
| ZIP/Postal code |
4056 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA92895 |
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