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Status |
Public on May 30, 2011 |
Title |
The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
SPC2996 is a novel locked nucleic acid (LNA) phosphorothioate antisense molecule targeting the mRNA of the Bcl-2 oncoprotein. We investigated the mechanism of action of SPC2996 and the basis for its clinically observed immunostimulatory effects in chronic lymphocytic leukemia (CLL). Patients with relapsed CLL were treated with a maximum of six doses of SPC2996 (0.2-6mg/ kg) in a multicenter phase I trial. Microarray-based transcriptional profiling of circulating CLL cells was carried out before and after the first infusion of SPC2996 in eighteen patients. We used microarrays to characterize global gene expression changes of circulating CLL cells in response to SPC2996 infusion in 18 patients Key word : Response to therapeutic agent
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Overall design |
We performed microarray-based gene expression profiling in serial peripheral blood samples from 18 individual CLL patients before and after treatment with SPC2996
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Contributor(s) |
Dürig J, Dührsen U, Klein-Hitpass L, Worm J, Rode Hansen JB, Ørum H, Wissenbach M |
Citation(s) |
21358717 |
Submission date |
Mar 09, 2011 |
Last update date |
Mar 25, 2019 |
Contact name |
Ludger Klein-Hitpass |
E-mail(s) |
ludger.klein-hitpass@uni-essen.de
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Phone |
+49 201 723 85552
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Organization name |
Institut fuer Zellbiologie
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Department |
Universitaetsklinikum
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Lab |
BioChip Lab
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Street address |
Virchowstr. 173
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City |
Essen |
ZIP/Postal code |
D-45122 |
Country |
Germany |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (56)
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Relations |
BioProject |
PRJNA137879 |