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| Status |
Public on May 06, 2011 |
| Title |
A Pathobiological Role of the Insulin Receptor in CLL. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized.
Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL with del11q. High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other genomic categories) was confirmed by Q-PCR in 247 CLL cases. INSR protein measurements in 257 CLL cases through FACS, compared with measurements in normal CD19+ B-cells and monocytes, confirmed that a subset of CLL aberrantly expresses high INSR levels.
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| Overall design |
We have employed integrated genomic profiling approaches upon CLL cases with and without del11q to identify 11q-relevant genes.
Included are 10 primary human cases with del11q and 9 cases without del11q
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| Contributor(s) |
Saiya-Cork K, Collins RL, Parkin B, Ouillette PD, Kuizon EG, Kujawski LA, Erba HP, Campagnaro E, Shedden KA, Kaminski MS, Malek SN |
| Citation(s) |
21307146 |
| Submission date |
Jan 10, 2011 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Sami N Malek |
| E-mail(s) |
smalek@med.umich.edu, pouillet@med.umich.edu
|
| Phone |
734-763-1222
|
| Organization name |
University of Michigan
|
| Department |
Internal Medicine, Hematology-Oncology
|
| Street address |
4410 Cancer Center; 1500 E Medical Center Dr
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA136641 |
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