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    LRRC37A leucine rich repeat containing 37A [ Homo sapiens (human) ]

    Gene ID: 9884, updated on 3-Apr-2024

    Summary

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    Official Symbol
    LRRC37Aprovided by HGNC
    Official Full Name
    leucine rich repeat containing 37Aprovided by HGNC
    Primary source
    HGNC:HGNC:29069
    See related
    Ensembl:ENSG00000176681 MIM:616555; AllianceGenome:HGNC:29069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC37; LRRC37A1
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 14.7), bone marrow (RPKM 4.6) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    17q21.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46248044..46337794)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47110074..47199790)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44372497..44415160)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene KANSL1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44337043-44337589 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 1 Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene ADP ribosylation factor like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene ADP ribosylation factor like GTPase 17A Neighboring gene RDM1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural evolution of the BRCA1 genomic region in primates. Jin H, et al. Genomics, 2004 Dec. PMID 15533724
    2. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. Bekpen C, et al. Genome Res, 2012 Jun. PMID 22419166, Free PMC Article
    3. Evolutionary dynamism of the primate LRRC37 gene family. Giannuzzi G, et al. Genome Res, 2013 Jan. PMID 23064749, Free PMC Article
    4. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). Hart AB, et al. PLoS One, 2012. PMID 22952603, Free PMC Article
    5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Feb 28. PMID 9628581

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0563, DKFZp686N1231

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 37A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014834.4 → NP_055649.4  leucine-rich repeat-containing protein 37A precursor

      See identical proteins and their annotated locations for NP_055649.4

      Status: VALIDATED

      Source sequence(s)
      AC005829, AC217777
      Consensus CDS
      CCDS11504.2
      UniProtKB/Swiss-Prot
      A6NMS7, Q68DY2, Q8IWC7
      UniProtKB/TrEMBL
      A0A0G2JNC9
      Related
      ENSP00000326324.5, ENST00000320254.5
      Conserved Domains (5) summary
      sd00031
      Location:891 → 914
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:892 → 929
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:892 → 949
      LRR_8; Leucine rich repeat
      pfam14914
      Location:1468 → 1613
      LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
      pfam15779
      Location:561 → 629
      LRRC37; Leucine-rich repeat-containing protein 37 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      46248044..46337794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437205.1 → XP_047293161.1  leucine-rich repeat-containing protein 37A isoform X10

    2. XM_047437200.1 → XP_047293156.1  leucine-rich repeat-containing protein 37A isoform X4

    3. XM_047437206.1 → XP_047293162.1  leucine-rich repeat-containing protein 37A isoform X9

      UniProtKB/TrEMBL
      E9PP10
      Related
      ENSP00000437021.1, ENST00000496930.5

    4. XM_047437196.1 → XP_047293152.1  leucine-rich repeat-containing protein 37A isoform X1

    5. XM_047437197.1 → XP_047293153.1  leucine-rich repeat-containing protein 37A isoform X2

    6. XM_047437198.1 → XP_047293154.1  leucine-rich repeat-containing protein 37A isoform X3

    7. XM_047437199.1 → XP_047293155.1  leucine-rich repeat-containing protein 37A isoform X5

    8. XM_047437201.1 → XP_047293157.1  leucine-rich repeat-containing protein 37A isoform X6

    9. XM_047437202.1 → XP_047293158.1  leucine-rich repeat-containing protein 37A isoform X7

    10. XM_047437204.1 → XP_047293160.1  leucine-rich repeat-containing protein 37A isoform X8

    11. XM_047437203.1 → XP_047293159.1  leucine-rich repeat-containing protein 37A isoform X11

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      413631..539475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328599.1 → XP_054184574.1  leucine-rich repeat-containing protein 37A isoform X10

    2. XM_054328591.1 → XP_054184566.1  leucine-rich repeat-containing protein 37A isoform X12

    3. XM_054328590.1 → XP_054184565.1  leucine-rich repeat-containing protein 37A isoform X12

    4. XM_054328600.1 → XP_054184575.1  leucine-rich repeat-containing protein 37A isoform X9

      UniProtKB/TrEMBL
      A0A0G2JQV0

    5. XM_054328594.1 → XP_054184569.1  leucine-rich repeat-containing protein 37A isoform X4

    6. XM_054328592.1 → XP_054184567.1  leucine-rich repeat-containing protein 37A isoform X13

    7. XM_054328593.1 → XP_054184568.1  leucine-rich repeat-containing protein 37A isoform X5

    8. XM_054328589.1 → XP_054184564.1  leucine-rich repeat-containing protein 37A isoform X3

    9. XM_054328588.1 → XP_054184563.1  leucine-rich repeat-containing protein 37A isoform X2

    10. XM_054328587.1 → XP_054184562.1  leucine-rich repeat-containing protein 37A isoform X1

    11. XM_054328598.1 → XP_054184573.1  leucine-rich repeat-containing protein 37A isoform X14

    12. XM_054328597.1 → XP_054184572.1  leucine-rich repeat-containing protein 37A isoform X8

    13. XM_054328595.1 → XP_054184570.1  leucine-rich repeat-containing protein 37A isoform X7

    14. XM_054328596.1 → XP_054184571.1  leucine-rich repeat-containing protein 37A isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47110074..47199790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318056.1 → XP_054174031.1  leucine-rich repeat-containing protein 37A isoform X10

    2. XM_054318054.1 → XP_054174029.1  leucine-rich repeat-containing protein 37A isoform X16

    3. XM_054318045.1 → XP_054174020.1  leucine-rich repeat-containing protein 37A isoform X15

    4. XM_054318055.1 → XP_054174030.1  leucine-rich repeat-containing protein 37A isoform X9

    5. XM_054318049.1 → XP_054174024.1  leucine-rich repeat-containing protein 37A isoform X4

    6. XM_054318046.1 → XP_054174021.1  leucine-rich repeat-containing protein 37A isoform X1

    7. XM_054318047.1 → XP_054174022.1  leucine-rich repeat-containing protein 37A isoform X2

    8. XM_054318048.1 → XP_054174023.1  leucine-rich repeat-containing protein 37A isoform X3

    9. XM_054318050.1 → XP_054174025.1  leucine-rich repeat-containing protein 37A isoform X5

    10. XM_054318051.1 → XP_054174026.1  leucine-rich repeat-containing protein 37A isoform X6

    11. XM_054318053.1 → XP_054174028.1  leucine-rich repeat-containing protein 37A isoform X8

    12. XM_054318052.1 → XP_054174027.1  leucine-rich repeat-containing protein 37A isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NMS7.3 GenPept UniProtKB/Swiss-Prot:A6NMS7

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