Conserved Protein Domain Family
LRRC37AB_C
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pfam14914: LRRC37AB_C (this model, PSSM-Id:291575 is obsolete and has been replaced by 464370)
LRRC37A/B like protein 1 C-terminal domain
This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.
Links
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Statistics
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PSSM-Id: 291575
Aligned: 22 rows
Threshold Bit Score: 170.615
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHB01776      759 SPGDEFETQLNQQLHVLIPNKEVRRFLWYMIRTFKRDCSEPSMHLACAKLISRTGLLMKLlmLSEQQEEKVVQAQWDTEQ 838  naked mole-rat
XP_008250810   52 SQGEQFEIQLNQQLQSLIPNTDVRRLISHVIRTLKMDCSEAQVQLPCAKLISKTGILMKL--LSEQQEEKIAKEEWDTEQ 129  rabbit
EHA98118      220 SPGDEFKTQLNQQLHILIPNKEVRRLISYIIRTLKMDCSEPCMQLACAKLISRTGLLMKL--LSGQQEEKVGQAQWDTEQ 297  naked mole-rat
EDM06273       63 SPEEQFESHLNQQLGTLIPNNDVRKLISHVIRTLKMDCSDPQVQLSCAKLISRTGLLMKL--LSEQQDFKLSRTDWDTDQ 140  Norway rat
XP_007655984  556 DQGDQFERDLDWRLQALIPNKAVRKLISHVIRTLKMDCTEPGVQLACAKLLSKTGLLMKL--LSEREEADGSQLMWSSGR 633  platypus
BAE20448     1248 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKL--LSEQQDFKLSRADWDTDQ 1325 house mouse
EHB01046     1265 SPRDGFESQLNQQLHLLVPNKEVRRLISHVTRTLKTDCSEPRMHLACAKLITRTGLLMKL--LSEQQEEAVAQAH----- 1337 naked mole-rat
XP_007482559 1217 pSDDKLESELNQQLQPLIPNKVFRGLISHITQTLQNDCTKPSLQVACAKLISRANLLMKL--LSEQEKMKEFHIDQNSDL 1294 gray short-ta...
XP_008111668  384 rKGDLFEAELNKRLATLIPNVPVRNLISHVIRILKMDCTEPTIQMACAKLISRTGLLMKL--FSDRENIKETSPLWESYF 461  green anole
XP_004999684  433 eeGDQFETYRDQQLGLLIPNNNIRRLISQVSRIVKMDCSEAHTQLACAKLVSRTGLLMKL--LSEEEKVHVAKALWDAED 510  domestic guin...

EHB01776      839 WKSETYIKESSGVSSNQKAQgEPRDHTQEVPGHDYNKKLILAILVTG--TSMLLIIILCLIKICSHRTASG 907  naked mole-rat
XP_008250810  130 WRTETYINESTEAPSGQKEQ-ESSKLAKGAQEHGYHNKLIVAISVTA--VVTMLVIIFCLIEIYSHRGRGR 197  rabbit
EHA98118      298 WKSETYINKSTGASSNQKAQgKPRNHTQEVPGHGYNN-IILEISVSAitIAMLLIIIFCLIEICSHRTASG 367  naked mole-rat
EDM06273      141 WKTETYVNQSRGAQGERKGL-EPDQRAKEASGFGYNKKVILAISVTV--VVIILIIAFCLIEVYSHRTKKG 208  Norway rat
XP_007655984  634 WRNGDYFNGSVDGNLTEDE--EARELSQDIPSYGYGNKLLLAISVTV--VIMTIIAAICLIEICSQRASSA 700  platypus
BAE20448     1326 WKTENYINENTETQSKLKSL-GRSQFGKEVSEFSYNNKVTLAISVTV--VVIVLIIIFCLIEICSHRTKKG 1393 house mouse
EHB01046     1338 -IKETY--KSSGASSNQKVQgEPRDHTQEVLGHTYKNKLIVATSVMA--ALTLLVFIFCLIEICSHRTASE 1403 naked mole-rat
XP_007482559 1295 WKNEPYLNDS----ATQLVLgDLKKSPKEIPEFSYNNKLLLAISVTV--VVMIIIAMICLIEVCSHRPTSP 1359 gray short-tailed opossum
XP_008111668  462 WPVKTAVNKSKPSSRKIEKP-SDEIARQGLPEYGYGNKILLAISVTA--AIMLIILAIGLYEICSQRSREG 529  green anole
XP_004999684  511 QKSEKDTSENTA-ESDHKDQ-KSREkaingfsspfwlrdiyqpisasqmrkvaaklhdessdedeiftkpa 579  domestic guinea pig
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